Lymphotoxins: new targets for hepatocellular carcinoma.

Authors

HCC Translational Research Laboratory, Barcelona-Clinic Liver Cancer Group, Liver Unit. Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clinic, BCN 08036, Barcelona, Spain.

Abstract

In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential therapeutic targets.

References

Villanueva A, Savic R, Llovet JM. Lymphotoxins: new targets for hepatocellular carcinoma. Cancer Cell. 2009;16;4
PubMed id : 19800570
doi : 10.1016/j.ccr.2009.09.012

Link to pubmed | Link to Google Scholar | Link to full text publication

2009

Cancer cell

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