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Roskams, Tania be

List of all publications

Publishing since 1993 (Senior)

    2010

  1. Journal Article Dietrich C, Weiss C, Bockamp E, Brisken C, Roskams T, Morris R, Oesch-Bartlomowicz B, Oesch F. Stem cells in chemical carcinogenesis.  Arch. Toxicol.  2010;84;3  Link to Stem cells in chemical carcinogenesis.
  2. Journal Article Spee B, Carpino G, Schotanus BA, Katoonizadeh A, Vander Borght S, Gaudio E, Roskams T. Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling.  Gut  2010;59;2  Link to Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling.
  3. Journal Article Roskams T, Kojiro M. Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis.  Semin. Liver Dis.  2010;30;1  Link to Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis.
  4. Journal Article van Sprundel RG, van den Ingh TS, Desmet VJ, Katoonizadeh A, Penning LC, Rothuizen J, Roskams T, Spee B. Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours.  Comp Hepatol  2010;9;1  Link to Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours.

    5. 2009

  5. Case ReportsJournal Article Darius T, Monbaliu D, Aerts R, Laleman W, Roskams T, Van Steenbergen W, Cassiman D, Verslype C, Maleux G, Nevens F, Pirenne J. Rescue of a marginal liver graft by sequential treatment with molecular adsorbent recirculating system and transjugular intrahepatic portosystemic shunt: a case report.  Transplant. Proc.  2009;41;8  Link to Rescue of a marginal liver graft by sequential treatment with molecular adsorbent recirculating system and transjugular intrahepatic portosystemic shunt: a case report.
  6. Journal Article Lin L, Libbrecht L, Verbeeck J, Verslype C, Roskams T, van Pelt J, Van Ranst M, Fevery J. Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance.  J. Med. Virol.  2009;81;9  Link to Quantitation of replication of the HCV genome in human livers with end-stage cirrhosis by strand-specific real-time RT-PCR assays: methods and clinical relevance.
  7. Journal Article Beraza N, Malato Y, Sander LE, Al-Masaoudi M, Freimuth J, Riethmacher D, Gores GJ, Roskams T, Liedtke C, Trautwein C. Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.  J. Exp. Med.  2009;206;8  Link to Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
  8. Case ReportsJournal Article Roelandt PR, Maertens J, Vandenberghe P, Verslype C, Roskams T, Aerts R, Nevens F, Dierickx D. Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.  Liver Transpl.  2009;15;7  Link to Hepatosplenic gammadelta T-cell lymphoma after liver transplantation: report of the first 2 cases and review of the literature.
  9. Journal Article Baldewijns MM, Roskams T, Ballet V, Van den Eynden GG, Van Laere SJ, Van der Auwera I, Lerut E, De Bruïne AP, Thijssen VL, Vermeulen PB, van Poppel H. A low frequency of lymph node metastasis in clear-cell renal cell carcinoma is related to low lymphangiogenic activity.  BJU Int.  2009;103;12  Link to A low frequency of lymph node metastasis in clear-cell renal cell carcinoma is related to low lymphangiogenic activity.
  10. Journal ArticleResearch Support, N.I.H., Intramural Kaposi-Novak P, Libbrecht L, Woo HG, Lee YH, Sears NC, Coulouarn C, Conner EA, Factor VM, Roskams T, Thorgeirsson SS. Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.  Cancer Res.  2009;69;7  Link to Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
  11. Journal ArticleValidation Studies Everaerts W, Sepúlveda MR, Gevaert T, Roskams T, Nilius B, De Ridder D. Where is TRPV1 expressed in the bladder, do we see the real channel?  Naunyn Schmiedebergs Arch. Pharmacol.  2009;379;4  Link to Where is TRPV1 expressed in the bladder, do we see the real channel?
  12. Journal ArticleReview Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M. Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?  Gut  2009;58;4  Link to Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?
  13. Journal Article Baldewijns MM, van Vlodrop IJ, Smits KM, Vermeulen PB, Van den Eynden GG, Schot F, Roskams T, van Poppel H, van Engeland M, de Bruïne AP. Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene.  Cellular oncology : the official journal of the International Society for Cellular Oncology  2009;31;5  Link to Different angiogenic potential in low and high grade sporadic clear cell renal cell carcinoma is not related to alterations in the von Hippel-Lindau gene.
  14. Journal Article Henckaerts L, Jaspers M, Van Steenbergen W, Vliegen L, Fevery J, Nuytten H, Roskams T, Rutgeerts P, Cassiman JJ, Vermeire S, Cuppens H. Cystic fibrosis transmembrane conductance regulator gene polymorphisms in patients with primary sclerosing cholangitis.  J. Hepatol.  2009;50;1  Link to Cystic fibrosis transmembrane conductance regulator gene polymorphisms in patients with primary sclerosing cholangitis.

    15. 2008

  15. Comparative StudyJournal Article Vander Borght S, Komuta M, Libbrecht L, Katoonizadeh A, Aerts R, Dymarkowski S, Verslype C, Nevens F, Roskams T. Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin.  Liver Int.  2008;28;10  Link to Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin.
  16. Journal ArticleReview Roskams T. Relationships among stellate cell activation, progenitor cells, and hepatic regeneration.  Clin Liver Dis  2008;12;4  Link to Relationships among stellate cell activation, progenitor cells, and hepatic regeneration.
  17. Journal Article Monbaliu D, Libbrecht L, De Vos R, Vekemans K, Walter H, Liu Q, Heedfeld V, Goossens V, Pirenne J, Roskams T. The extent of vacuolation in non-heart-beating porcine donor liver grafts prior to transplantation predicts their viability.  Liver Transpl.  2008;14;9  Link to The extent of vacuolation in non-heart-beating porcine donor liver grafts prior to transplantation predicts their viability.
  18. Case ReportsJournal Article Cornelis T, Claes K, Gillard P, Nijs E, Roskams T, Lombaerts R, Nevens F, Cassiman D. Cholestatic liver disease in long-term infantile nephropathic cystinosis.  J. Gastroenterol. Hepatol.  2008;23;8 Pt 2  Link to Cholestatic liver disease in long-term infantile nephropathic cystinosis.
  19. Comparative StudyJournal Article Hannivoort RA, Dunning S, Vander Borght S, Schroyen B, Woudenberg J, Oakley F, Buist-Homan M, van den Heuvel FA, Geuken M, Geerts A, Roskams T, Faber KN, Moshage H. Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells.  Hepatology  2008;48;2  Link to Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells.
  20. Journal Article Luedde T, Heinrichsdorff J, de Lorenzi R, De Vos R, Roskams T, Pasparakis M. IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.  Proc. Natl. Acad. Sci. U.S.A.  2008;105;28  Link to IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.
  21. Journal Article Rebouissou S, Couchy G, Libbrecht L, Balabaud C, Imbeaud S, Auffray C, Roskams T, Bioulac-Sage P, Zucman-Rossi J. The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodules.  J. Hepatol.  2008;49;1  Link to The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodules.
  22. Journal Article Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, de Vos R, Roskams T, Trautwein C. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis.  Gut  2008;57;5  Link to Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis.
  23. Journal Article Komuta M, Spee B, Vander Borght S, De Vos R, Verslype C, Aerts R, Yano H, Suzuki T, Matsuda M, Fujii H, Desmet VJ, Kojiro M, Roskams T. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin.  Hepatology  2008;47;5  Link to Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin.
  24. Journal Article Guido M, Roskams T, Pontisso P, Fassan M, Thung SN, Giacomelli L, Sergio A, Farinati F, Cillo U, Rugge M. Squamous cell carcinoma antigen in human liver carcinogenesis.  J. Clin. Pathol.  2008;61;4  Link to Squamous cell carcinoma antigen in human liver carcinogenesis.
  25. Comparative StudyJournal Article Cassiman D, Vannoote J, Roelandts R, Libbrecht L, Roskams T, Van den Oord J, Fevery J, Garmyn M, Nevens F. Porphyria cutanea tarda and liver disease. A retrospective analysis of 17 cases from a single centre and review of the literature.  Acta Gastroenterol. Belg.  2008;71;2  Link to Porphyria cutanea tarda and liver disease. A retrospective analysis of 17 cases from a single centre and review of the literature.
  26. Journal Article Woo HG, Park ES, Cheon JH, Kim JH, Lee JS, Park BJ, Kim W, Park SC, Chung YJ, Kim BG, Yoon JH, Lee HS, Kim CY, Yi NJ, Suh KS, Lee KU, Chu IS, Roskams T, Thorgeirsson SS, Kim YJ. Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma.  Clin. Cancer Res.  2008;14;7  Link to Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma.
  27. Journal Article De Minicis S, Candelaresi C, Marzioni M, Saccomano S, Roskams T, Casini A, Risaliti A, Salzano R, Cautero N, di Francesco F, Benedetti A, Svegliati-Baroni G. Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo.  Gut  2008;57;3  Link to Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo.
  28. Comparative StudyJournal Article Clotman F, Libbrecht L, Killingsworth MC, Loo CC, Roskams T, Lemaigre FP. Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome.  Liver Int.  2008;28;3  Link to Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome.
  29. Journal ArticleResearch Support, N.I.H., Extramural Fabris L, Cadamuro M, Libbrecht L, Raynaud P, Spirlì C, Fiorotto R, Okolicsanyi L, Lemaigre F, Strazzabosco M, Roskams T. Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development.  Hepatology  2008;47;2  Link to Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development.

    30. 2007

  30. Journal Article Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, Talavera K, Owsianik G, Liedtke W, Daelemans D, Dewachter I, Van Leuven F, Voets T, De Ridder D, Nilius B. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.  J. Clin. Invest.  2007;117;11  Link to Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.
  31. Journal Article Huygens A, Crnolatac I, Maes J, Van Cleynenbreugel B, Van Poppel H, Roskams T, de Witte PA. Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.  BJU Int.  2007;100;5  Link to Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.
  32. Journal Article Monbaliu D, Vekemans K, De Vos R, Brassil J, Heedfeld V, Qiang L, D'hollander M, Roskams T, Pirenne J. Hemodynamic, biochemical, and morphological characteristics during preservation of normal porcine livers by hypothermic machine perfusion.  Transplant. Proc.  2007;39;8  Link to Hemodynamic, biochemical, and morphological characteristics during preservation of normal porcine livers by hypothermic machine perfusion.
  33. Evaluation StudiesJournal Article Vanwolleghem T, Meuleman P, Libbrecht L, Roskams T, De Vos R, Leroux-Roels G. Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse.  Gastroenterology  2007;133;4  Link to Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse.
  34. Journal Article Klein C, Medina E, Sander L, Dierssen U, Roskams T, Mueller W, Trautwein C, Goldmann O. Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes.  J. Infect. Dis.  2007;196;5  Link to Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes.
  35. Journal Article Baldewijns MM, Thijssen VL, Van den Eynden GG, Van Laere SJ, Bluekens AM, Roskams T, van Poppel H, De Bruïne AP, Griffioen AW, Vermeulen PB. High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile.  Br. J. Cancer  2007;96;12  Link to High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile.
  36. Journal Article Beraza N, Lüdde T, Assmus U, Roskams T, Vander Borght S, Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.  Gastroenterology  2007;132;7  Link to Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.
  37. Letter Henckaerts L, Fevery J, Van Steenbergen W, Verslype C, Nevens F, Yap P, Roskams T, Rutgeerts P, Vermeire S. The RANTES -28 g polymorphism is associated with primary sclerosing cholangitis.  Gut  2007;56;6  Link to The RANTES -28 g polymorphism is associated with primary sclerosing cholangitis.
  38. Journal Article Katoonizadeh A, Decaestecker J, Wilmer A, Aerts R, Verslype C, Vansteenbergen W, Yap P, Fevery J, Roskams T, Pirenne J, Nevens F. MELD score to predict outcome in adult patients with non-acetaminophen-induced acute liver failure.  Liver Int.  2007;27;3  Link to MELD score to predict outcome in adult patients with non-acetaminophen-induced acute liver failure.
  39. Journal Article Cassiman D, Sinelli N, Bockx I, Vander Borght S, Petersen B, De Vos R, van Pelt J, Nevens F, Libbrecht L, Roskams T. Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endings.  Liver Int.  2007;27;3  Link to Human hepatic progenitor cells express vasoactive intestinal peptide receptor type 2 and receive nerve endings.
  40. Journal ArticleReview Bioulac-Sage P, Balabaud C, Bedossa P, Scoazec JY, Chiche L, Dhillon AP, Ferrell L, Paradis V, Roskams T, Vilgrain V, Wanless IR, Zucman-Rossi J. Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update.  J. Hepatol.  2007;46;3  Link to Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update.
  41. Journal Article Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.  Cancer Cell  2007;11;2  Link to Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.
  42. Journal Article Laleman W, Van Landeghem L, Severi T, Vander Elst I, Zeegers M, Bisschops R, Van Pelt J, Roskams T, Cassiman D, Fevery J, Nevens F. Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine.  Am. J. Physiol. Gastrointest. Liver Physiol.  2007;292;2  Link to Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine.
  43. Comparative StudyJournal Article Hsu CY, Joniau S, Roskams T, Oyen R, Van Poppel H. Comparing results after surgery in patients with clinical unilateral T3a prostate cancer treated with or without neoadjuvant androgen-deprivation therapy.  BJU Int.  2007;99;2  Link to Comparing results after surgery in patients with clinical unilateral T3a prostate cancer treated with or without neoadjuvant androgen-deprivation therapy.
  44. Journal Article Hsu CY, Joniau S, Oyen R, Roskams T, Van Poppel H. Transrectal ultrasound in the staging of clinical T3a prostate cancer.  Eur J Surg Oncol  2007;33;1  Link to Transrectal ultrasound in the staging of clinical T3a prostate cancer.
  45. Journal Article Spee B, Arends B, van den Ingh TS, Roskams T, Rothuizen J, Penning LC. Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis.  Comp Hepatol  2007;6  Link to Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis.

    46. 2006

  46. Journal Article Katoonizadeh A, Nevens F, Verslype C, Pirenne J, Roskams T. Liver regeneration in acute severe liver impairment: a clinicopathological correlation study.  Liver Int.  2006;26;10  Link to Liver regeneration in acute severe liver impairment: a clinicopathological correlation study.
  47. Journal Article Libbrecht L, Severi T, Cassiman D, Vander Borght S, Pirenne J, Nevens F, Verslype C, van Pelt J, Roskams T. Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules.  Am. J. Surg. Pathol.  2006;30;11  Link to Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules.
  48. Journal ArticleReview Libbrecht L, Roskams T. Molecular diagnostic approach to liver tissue as an ancillary tool for liver histopathology.  Semin. Liver Dis.  2006;26;4  Link to Molecular diagnostic approach to liver tissue as an ancillary tool for liver histopathology.
  49. Comparative StudyEvaluation StudiesJournal Article Hsu CY, Joniau S, Oyen R, Roskams T, Van Poppel H. Detection of clinical unilateral T3a prostate cancer - by digital rectal examination or transrectal ultrasonography?  BJU Int.  2006;98;5  Link to Detection of clinical unilateral T3a prostate cancer - by digital rectal examination or transrectal ultrasonography?
  50. Journal Article Libbrecht L, Cassiman D, Verslype C, Maleux G, Van Hees D, Pirenne J, Nevens F, Roskams T. Clinicopathological features of focal nodular hyperplasia-like nodules in 130 cirrhotic explant livers.  Am. J. Gastroenterol.  2006;101;10  Link to Clinicopathological features of focal nodular hyperplasia-like nodules in 130 cirrhotic explant livers.
  51. Case ReportsJournal Article Lerut E, Roskams T, Joniau S, Oyen R, Achten R, Van Poppel H, Debiec-Rychter M. Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics.  Hum. Pathol.  2006;37;9  Link to Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics.
  52. Journal Article Durnez A, Verslype C, Nevens F, Fevery J, Aerts R, Pirenne J, Lesaffre E, Libbrecht L, Desmet V, Roskams T. The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin.  Histopathology  2006;49;2  Link to The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin.
  53. Comparative StudyJournal Article Spee B, Arends B, van den Ingh TS, Brinkhof B, Nederbragt H, Ijzer J, Roskams T, Penning LC, Rothuizen J. Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies.  Liver Int.  2006;26;6  Link to Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies.
  54. Journal ArticleReview Schöffski P, Dumez H, Clement P, Hoeben A, Prenen H, Wolter P, Joniau S, Roskams T, Van Poppel H. Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review.  Ann. Oncol.  2006;17;8  Link to Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review.
  55. CommentEditorial Roskams T. Different types of liver progenitor cells and their niches.  J. Hepatol.  2006;45;1  Link to Different types of liver progenitor cells and their niches.
  56. Journal ArticleReview Roskams T. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma.  Oncogene  2006;25;27  Link to Liver stem cells and their implication in hepatocellular and cholangiocarcinoma.
  57. Journal Article Fabris L, Cadamuro M, Fiorotto R, Roskams T, Spirlì C, Melero S, Sonzogni A, Joplin RE, Okolicsanyi L, Strazzabosco M. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases.  Hepatology  2006;43;5  Link to Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases.
  58. Comparative StudyJournal Article Henckaerts L, Fevery J, Van Steenbergen W, Verslype C, Yap P, Nevens F, Roskams T, Libbrecht L, Rutgeerts P, Vermeire S. CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis.  Inflamm. Bowel Dis.  2006;12;4  Link to CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis.
  59. Journal Article Laleman W, Vander Elst I, Zeegers M, Servaes R, Libbrecht L, Roskams T, Fevery J, Nevens F. A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited.  Eur. J. Clin. Invest.  2006;36;4  Link to A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited.
  60. Comparative StudyJournal ArticleResearch Support, N.I.H., Intramural Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, Mikaelyan A, Roberts LR, Demetris AJ, Sun Z, Nevens F, Roskams T, Thorgeirsson SS. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.  Nat. Med.  2006;12;4  Link to A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.
  61. Journal Article Reynaert H, Van Vlierberghe H, De Beeck BO, Roskams T. Management of small focal liver lesions in a cirrhotic liver: discussion.  Acta Gastroenterol. Belg.  2006;69;2  Link to Management of small focal liver lesions in a cirrhotic liver: discussion.
  62. Journal ArticleResearch Support, N.I.H., Extramural Meuleman P, Libbrecht L, Wieland S, De Vos R, Habib N, Kramvis A, Roskams T, Leroux-Roels G. Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus.  J. Virol.  2006;80;6  Link to Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus.
  63. Journal Article Kamuhabwa AR, Huygens A, Roskams T, De Witte PA. Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin.  Int. J. Oncol.  2006;28;3  Link to Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin.
  64. Comparative StudyJournal Article Van De Putte M, Roskams T, Bormans G, Verbruggen A, De Witte PA. The impact of aggregation on the biodistribution of hypericin.  Int. J. Oncol.  2006;28;3  Link to The impact of aggregation on the biodistribution of hypericin.
  65. Journal Article Ijzer J, Roskams T, Molenbeek RF, Ultee T, Penning LC, Rothuizen J, van den Ingh TS. Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver.  Comp Hepatol  2006;5  Link to Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver.

    66. 2005

  66. Journal Article Laleman W, Omasta A, Van de Casteele M, Zeegers M, Vander Elst I, Van Landeghem L, Severi T, van Pelt J, Roskams T, Fevery J, Nevens F. A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis.  Hepatology  2005;42;6  Link to A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis.
  67. Journal Article Liedtke C, Zschemisch NH, Cohrs A, Roskams T, Borlak J, Manns MP, Trautwein C. Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element.  Gastroenterology  2005;129;5  Link to Silencing of caspase-8 in murine hepatocellular carcinomas is mediated via methylation of an essential promoter element.
  68. Case ReportsJournal Article Buchel O, Roskams T, Van Damme B, Nevens F, Pirenne J, Fevery J. Nodular regenerative hyperplasia, portal vein thrombosis, and avascular hip necrosis due to hyperhomocysteinaemia.  Gut  2005;54;7  Link to Nodular regenerative hyperplasia, portal vein thrombosis, and avascular hip necrosis due to hyperhomocysteinaemia.
  69. CommentLetter Libbrecht L, Maleux G, Verslype C, Nevens F, Roskams T. Influence of TIPS on development of hepatocellular carcinoma in cirrhosis.  Hepatology  2005;42;1  Link to Influence of TIPS on development of hepatocellular carcinoma in cirrhosis.
  70. Journal Article Topal B, Aerts JL, Roskams T, Fieuws S, Van Pelt J, Vandekerckhove P, Penninckx F. Cancer cell dissemination during curative surgery for colorectal liver metastases.  Eur J Surg Oncol  2005;31;5  Link to Cancer cell dissemination during curative surgery for colorectal liver metastases.
  71. Case ReportsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Libbrecht L, Spinner NB, Moore EC, Cassiman D, Van Damme-Lombaerts R, Roskams T. Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: further evidence supporting a lack of postnatal bile duct branching and elongation.  Am. J. Surg. Pathol.  2005;29;6  Link to Peripheral bile duct paucity and cholestasis in the liver of a patient with Alagille syndrome: further evidence supporting a lack of postnatal bile duct branching and elongation.
  72. Journal Article Van de Sande T, Roskams T, Lerut E, Joniau S, Van Poppel H, Verhoeven G, Swinnen JV. High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.  J. Pathol.  2005;206;2  Link to High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.
  73. Journal Article Huygens A, Kamuhabwa AR, Van Laethem A, Roskams T, Van Cleynenbreugel B, Van Poppel H, Agostinis P, De Witte PA. Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation.  Int. J. Oncol.  2005;26;6  Link to Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation.
  74. Journal Article Monbaliu D, Crabbé T, Roskams T, Fevery J, Verwaest C, Pirenne J. Livers from non-heart-beating donors tolerate short periods of warm ischemia.  Transplantation  2005;79;9  Link to Livers from non-heart-beating donors tolerate short periods of warm ischemia.
  75. Comparative StudyJournal Article Van de Putte M, Roskams T, Vandenheede JR, Agostinis P, de Witte PA. Elucidation of the tumoritropic principle of hypericin.  Br. J. Cancer  2005;92;8  Link to Elucidation of the tumoritropic principle of hypericin.
  76. Journal Article Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.  J. Clin. Invest.  2005;115;4  Link to Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
  77. Journal Article Klein C, Wüstefeld T, Assmus U, Roskams T, Rose-John S, Müller M, Manns MP, Ernst M, Trautwein C. The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.  J. Clin. Invest.  2005;115;4  Link to The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
  78. Journal Article Meuleman P, Libbrecht L, De Vos R, de Hemptinne B, Gevaert K, Vandekerckhove J, Roskams T, Leroux-Roels G. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera.  Hepatology  2005;41;4  Link to Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera.
  79. Case ReportsJournal Article Billiau AD, Roskams T, Van Damme-Lombaerts R, Matthys P, Wouters C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages.  Blood  2005;105;4  Link to Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages.
  80. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Dharancy S, Malapel M, Perlemuter G, Roskams T, Cheng Y, Dubuquoy L, Podevin P, Conti F, Canva V, Philippe D, Gambiez L, Mathurin P, Paris JC, Schoonjans K, Calmus Y, Pol S, Auwerx J, Desreumaux P. Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.  Gastroenterology  2005;128;2  Link to Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.
  81. Journal ArticleReview Libbrecht L, Desmet V, Roskams T. Preneoplastic lesions in human hepatocarcinogenesis.  Liver Int.  2005;25;1  Link to Preneoplastic lesions in human hepatocarcinogenesis.
  82. Journal Article Huygens A, Kamuhabwa AR, van Cleynenbreugel B, van Poppel H, Roskams T, de Witte PA. In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder.  BJU Int.  2005;95;3  Link to In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder.
  83. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Marzioni M, Glaser S, Francis H, Marucci L, Benedetti A, Alvaro D, Taffetani S, Ueno Y, Roskams T, Phinizy JL, Venter J, Fava G, Lesage GD, Alpini G. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.  Gastroenterology  2005;128;1  Link to Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.
  84. Journal ArticleReview Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules.  Semin. Liver Dis.  2005;25;2  Link to Early hepatocellular carcinoma and dysplastic nodules.
  85. Journal Article Monbaliu D, de Vries B, Crabbé T, van Heurn E, Verwaest C, Roskams T, Fevery J, Pirenne J, Buurman WA. Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors.  Transplant. Proc.  2005;37;1  Link to Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors.
  86. Journal Article Derveaux K, Monbaliu D, Crabbé T, Schein D, Brassil J, Kravitz D, Fevery J, Jacobbi L, Roskams T, Pirenne J. Does ex vivo vascular resistance reflect viability of non-heart-beating donor livers?  Transplant. Proc.  2005;37;1  Link to Does ex vivo vascular resistance reflect viability of non-heart-beating donor livers?

    87. 2004

  87. Clinical TrialJournal Article Rosenberg WM, Voelker M, Thiel R, Becka M, Burt A, Schuppan D, Hubscher S, Roskams T, Pinzani M, Arthur MJ. Serum markers detect the presence of liver fibrosis: a cohort study.  Gastroenterology  2004;127;6  Link to Serum markers detect the presence of liver fibrosis: a cohort study.
  88. Journal Article Derycke AS, Kamuhabwa A, Gijsens A, Roskams T, De Vos D, Kasran A, Huwyler J, Missiaen L, de Witte PA. Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells.  J. Natl. Cancer Inst.  2004;96;21  Link to Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells.
  89. Journal ArticleResearch Support, U.S. Gov't, P.H.S. LeSage GD, Alvaro D, Glaser S, Francis H, Marucci L, Roskams T, Phinizy JL, Marzioni M, Benedetti A, Taffetani S, Barbaro B, Fava G, Ueno Y, Alpini G. Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP.  Hepatology  2004;40;5  Link to Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP.
  90. Case ReportsJournal Article Pirenne J, Deloose K, Coosemans W, Aerts R, Van Gelder F, Kuypers D, Maes B, Verslype C, Yap P, Van Steenbergen W, Roskams T, Mathieu C, Fevery J, Nevens F. Combined 'en bloc' liver and pancreas transplantation in patients with liver disease and type 1 diabetes mellitus.  Am. J. Transplant.  2004;4;11  Link to Combined 'en bloc' liver and pancreas transplantation in patients with liver disease and type 1 diabetes mellitus.
  91. Journal Article Van de Casteele M, Roskams T, Van der Elst I, van Pelt JF, Fevery J, Nevens F. Halofuginone can worsen liver fibrosis in bile duct obstructed rats.  Liver Int.  2004;24;5  Link to Halofuginone can worsen liver fibrosis in bile duct obstructed rats.
  92. Journal Article Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, Durnez A, Demetris AJ, Thorgeirsson SS. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.  Hepatology  2004;40;3  Link to Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.
  93. CommentLetter Libbrecht L, Roskams T. Stellate-type scirrhous dysplastic nodules in liver cirrhosis: identical to focal nodular hyperplasia-like nodules?  J. Gastroenterol. Hepatol.  2004;19;8  Link to Stellate-type scirrhous dysplastic nodules in liver cirrhosis: identical to focal nodular hyperplasia-like nodules?
  94. Journal Article van Pelt JF, Severi T, Crabbé T, Eetveldt AV, Verslype C, Roskams T, Fevery J. Expression of hepatitis C virus core protein impairs DNA repair in human hepatoma cells.  Cancer Lett.  2004;209;2  Link to Expression of hepatitis C virus core protein impairs DNA repair in human hepatoma cells.
  95. Clinical TrialJournal ArticleRandomized Controlled Trial Farci P, Roskams T, Chessa L, Peddis G, Mazzoleni AP, Scioscia R, Serra G, Lai ME, Loy M, Caruso L, Desmet V, Purcell RH, Balestrieri A. Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis.  Gastroenterology  2004;126;7  Link to Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis.
  96. Journal ArticleReview Desmet VJ, Roskams T. Cirrhosis reversal: a duel between dogma and myth.  J. Hepatol.  2004;40;5  Link to Cirrhosis reversal: a duel between dogma and myth.
  97. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, Thomas SA, Diehl AM. Hepatic fibrogenesis requires sympathetic neurotransmitters.  Gut  2004;53;3  Link to Hepatic fibrogenesis requires sympathetic neurotransmitters.
  98. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Yang S, Koteish A, Lin H, Huang J, Roskams T, Dawson V, Diehl AM. Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.  Hepatology  2004;39;2  Link to Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease.

    99. 2003

  99. Journal Article Kamuhabwa AA, Roskams T, D'Hallewin MA, Baert L, Van Poppel H, de Witte PA. Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin.  Int. J. Cancer  2003;107;3  Link to Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin.
  100. Clinical TrialJournal ArticleRandomized Controlled Trial Nevens F, Roskams T, Van Vlierberghe H, Horsmans Y, Sprengers D, Elewaut A, Desmet V, Leroux-Roels G, Quinaux E, Depla E, Dincq S, Vander Stichele C, Maertens G, Hulstaert F. A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C.  Hepatology  2003;38;5  Link to A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C.
  101. Journal Article Clotman F, Libbrecht L, Gresh L, Yaniv M, Roskams T, Rousseau GG, Lemaigre FP. Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development.  J. Hepatol.  2003;39;5  Link to Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development.
  102. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Roskams T, Yang SQ, Koteish A, Durnez A, DeVos R, Huang X, Achten R, Verslype C, Diehl AM. Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease.  Am. J. Pathol.  2003;163;4  Link to Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease.
  103. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Oben JA, Roskams T, Yang S, Lin H, Sinelli N, Li Z, Torbenson M, Huang J, Guarino P, Kafrouni M, Diehl AM. Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury.  Hepatology  2003;38;3  Link to Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury.
  104. Case ReportsJournal Article Debiec-Rychter M, Croes R, De Vos R, Marynen P, Roskams T, Hagemeijer A, Lombaerts R, Sciot R. Complex genomic rearrangement of ALK loci associated with integrated human Epstein-Barr virus in a post-transplant myogenic liver tumor.  Am. J. Pathol.  2003;163;3  Link to Complex genomic rearrangement of ALK loci associated with integrated human Epstein-Barr virus in a post-transplant myogenic liver tumor.
  105. CommentEditorialReview Roskams T. Progenitor cell involvement in cirrhotic human liver diseases: from controversy to consensus.  J. Hepatol.  2003;39;3  Link to Progenitor cell involvement in cirrhotic human liver diseases: from controversy to consensus.
  106. CommentLetter Desmet VJ, Roskams T. Reversal of cirrhosis: evidence-based medicine?  Gastroenterology  2003;125;2  Link to Reversal of cirrhosis: evidence-based medicine?
  107. Journal Article Pirenne J, Aerts R, Koshiba T, Van Gelder F, Roskams T, Schetz M, Verhaegen M, Lauwers P, Fevery J, Nevens F. Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up report.  Clin Transplant  2003;17;3  Link to Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up report.
  108. Journal Article Topal B, Roskams T, Fevery J, Penninckx F. Aggregated colon cancer cells have a higher metastatic efficiency in the liver compared with nonaggregated cells: an experimental study.  J. Surg. Res.  2003;112;1  Link to Aggregated colon cancer cells have a higher metastatic efficiency in the liver compared with nonaggregated cells: an experimental study.
  109. Case ReportsLetter Libbrecht L, Desmet V, Roskams T. Stages of normal and aberrant intrahepatic bile duct development in a mixed hepatoblastoma.  Histopathology  2003;42;6  Link to Stages of normal and aberrant intrahepatic bile duct development in a mixed hepatoblastoma.
  110. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Glaser S, Alvaro D, Roskams T, Phinizy JL, Stoica G, Francis H, Ueno Y, Barbaro B, Marzioni M, Mauldin J, Rashid S, Mancino MG, LeSage G, Alpini G. Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.  Am. J. Physiol. Gastrointest. Liver Physiol.  2003;284;4  Link to Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.
  111. Journal Article Kamuhabwa AA, Roskams T, Baert L, De Witte PA. Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation.  Int. J. Oncol.  2003;22;4  Link to Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation.
  112. Journal Article Spirlì C, Fabris L, Duner E, Fiorotto R, Ballardini G, Roskams T, Larusso NF, Sonzogni A, Okolicsanyi L, Strazzabosco M. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.  Gastroenterology  2003;124;3  Link to Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
  113. Journal Article Verslype C, Nevens F, Sinelli N, Clarysse C, Pirenne J, Depla E, Maertens G, van Pelt J, Desmet V, Fevery J, Roskams T. Hepatic immunohistochemical staining with a monoclonal antibody against HCV-E2 to evaluate antiviral therapy and reinfection of liver grafts in hepatitis C viral infection.  J. Hepatol.  2003;38;2  Link to Hepatic immunohistochemical staining with a monoclonal antibody against HCV-E2 to evaluate antiviral therapy and reinfection of liver grafts in hepatitis C viral infection.
  114. Journal Article Libbrecht L, Meerman L, Kuipers F, Roskams T, Desmet V, Jansen P. Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria.  J. Pathol.  2003;199;2  Link to Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria.
  115. Journal ArticleReview Roskams T, Baptista A, Bianchi L, Burt A, Callea F, Denk H, De Groote J, Desmet V, Hubscher S, Ishak K, MacSween R, Portmann B, Poulson H, Scheuer P, Terracciano L, Thaler H. Histopathology of portal hypertension: a practical guideline.  Histopathology  2003;42;1  Link to Histopathology of portal hypertension: a practical guideline.

    116. 2002

  116. Journal ArticleReview Cassiman D, Roskams T. Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research.  J. Hepatol.  2002;37;4  Link to Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research.
  117. Journal Article Libbrecht L, Bielen D, Verslype C, Vanbeckevoort D, Pirenne J, Nevens F, Desmet V, Roskams T. Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations.  Liver Transpl.  2002;8;9  Link to Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations.
  118. Journal Article Van de Casteele M, Omasta A, Janssens S, Roskams T, Desmet V, Nevens F, Fevery J. In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats.  Gut  2002;51;3  Link to In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats.
  119. Journal Article De Vos R, Verslype C, Depla E, Fevery J, Van Damme B, Desmet V, Roskams T. Ultrastructural visualization of hepatitis C virus components in human and primate liver biopsies.  J. Hepatol.  2002;37;3  Link to Ultrastructural visualization of hepatitis C virus components in human and primate liver biopsies.
  120. Journal Article Cassiman D, Libbrecht L, Sinelli N, Desmet V, Denef C, Roskams T. The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3.  Am. J. Pathol.  2002;161;2  Link to The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3.
  121. Journal Article Libbrecht L, Cassiman D, Desmet V, Roskams T. The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver.  Liver  2002;22;3  Link to The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver.
  122. Journal ArticleReview Roskams T. The role of immunohistochemistry in diagnosis.  Clin Liver Dis  2002;6;2  Link to The role of immunohistochemistry in diagnosis.
  123. Journal Article D'Hallewin MA, Kamuhabwa AR, Roskams T, De Witte PA, Baert L. Hypericin-based fluorescence diagnosis of bladder carcinoma.  BJU Int.  2002;89;7  Link to Hypericin-based fluorescence diagnosis of bladder carcinoma.
  124. Journal Article Chen B, Roskams T, Xu Y, Agostinis P, de Witte PA. Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.  Int. J. Cancer  2002;98;2  Link to Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.
  125. Case ReportsJournal ArticleReview Itterbeek P, Vandenberghe P, Nevens F, Fevery J, Aerts R, Yap SH, Demuynck H, Fourneau I, Koshiba T, Emonds MP, Roskams T, Boogaerts M, Pirenne J. Aplastic anemia after transplantation for non-A, non-B, non-C fulminant hepatic failure: case report and review of the literature.  Transpl. Int.  2002;15;2-3  Link to Aplastic anemia after transplantation for non-A, non-B, non-C fulminant hepatic failure: case report and review of the literature.
  126. Journal Article Swinnen JV, Roskams T, Joniau S, Van Poppel H, Oyen R, Baert L, Heyns W, Verhoeven G. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.  Int. J. Cancer  2002;98;1  Link to Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.
  127. Journal Article Quadri R, Giostra E, Roskams T, Pawlotsky JM, Mentha G, Rubbia-Brandt L, Perrin L, Hadengue A, Negro F. Immunological and virological effects of ribavirin in hepatitis C after liver transplantation.  Transplantation  2002;73;3  Link to Immunological and virological effects of ribavirin in hepatitis C after liver transplantation.
  128. Journal Article Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers.  J. Hepatol.  2002;36;2  Link to Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers.
  129. Journal Article Kamuhabwa AA, Cosserat-Gerardin I, Didelon J, Notter D, Guillemin F, Roskams T, D'Hallewin MA, Baert L, de Witte PA. Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.  Int. J. Cancer  2002;97;2  Link to Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.

    130. 2001

  130. CommentEditorialReview Jansen PL, Roskams T. Why are patients with liver disease jaundiced? ATP-binding cassette transporter expression in human liver disease.  J. Hepatol.  2001;35;6  Link to Why are patients with liver disease jaundiced? ATP-binding cassette transporter expression in human liver disease.
  131. Journal Article Libbrecht L, De Vos R, Cassiman D, Desmet V, Aerts R, Roskams T. Hepatic progenitor cells in hepatocellular adenomas.  Am. J. Surg. Pathol.  2001;25;11  Link to Hepatic progenitor cells in hepatocellular adenomas.
  132. Journal Article Cassiman D, Roskams T, van Pelt J, Libbrecht L, Aertsen P, Crabbé T, Vankelecom H, Denef C. Alpha B-crystallin expression in human and rat hepatic stellate cells.  J. Hepatol.  2001;35;2  Link to Alpha B-crystallin expression in human and rat hepatic stellate cells.
  133. Journal Article Chen B, Xu Y, Roskams T, Delaey E, Agostinis P, Vandenheede JR, de Witte P. Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.  Int. J. Cancer  2001;93;2  Link to Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.
  134. Journal Article Libbrecht L, Craninx M, Nevens F, Desmet V, Roskams T. Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non-cirrhotic and cirrhotic chronic viral hepatitis.  Histopathology  2001;39;1  Link to Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with non-cirrhotic and cirrhotic chronic viral hepatitis.
  135. Journal Article Pirenne J, Aerts R, Yoong K, Gunson B, Koshiba T, Fourneau I, Mayer D, Buckels J, Mirza D, Roskams T, Elias E, Nevens F, Fevery J, McMaster P. Liver transplantation for polycystic liver disease.  Liver Transpl.  2001;7;3  Link to Liver transplantation for polycystic liver disease.
  136. Journal ArticleMulticenter Study Pirenne J, Aerts R, Yoong K, Gunson B, Koshiba T, Fourneau I, Roskams T, Elias E, Nevens F, Fevery J, Mayer D, Buckels J, Mirza D, McMaster P. Surgical strategy in liver transplantation for polycystic liver disease.  Transplant. Proc.  2001;33;1-2  Link to Surgical strategy in liver transplantation for polycystic liver disease.
  137. Journal Article Pirenne J, Aerts R, Koshiba T, Van Gelder F, Roskams T, Nevens F, Fevery J. Standard cyclosporine A-based versus completely steroid-free FK506-based immunosuppression after liver transplantation.  Transplant. Proc.  2001;33;1-2  Link to Standard cyclosporine A-based versus completely steroid-free FK506-based immunosuppression after liver transplantation.
  138. Journal Article Cassiman D, Denef C, Desmet VJ, Roskams T. Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors.  Hepatology  2001;33;1  Link to Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors.

    139. 2000

  139. Comparative StudyJournal Article Libbrecht L, Desmet V, Van Damme B, Roskams T. Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate?  J. Pathol.  2000;192;3  Link to Deep intralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can 'progenitor cells' migrate?
  140. Journal ArticleReview Petrovich Z, Baert LV, Brady LW, De Ridder DJ, Goethuys H, Nijman R, Oyen R, Ozer H, Roskams T, Stein JP, Stockx L, Van Oosterom A, Van Poppel HP, Van Uytsel L. Carcinoma of the kidney, testis, and rare urologic malignancies.  Am. J. Clin. Oncol.  2000;23;5  Link to Carcinoma of the kidney, testis, and rare urologic malignancies.
  141. Journal Article Libbrecht L, Desmet V, Van Damme B, Roskams T. The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells.  J. Hepatol.  2000;33;1  Link to The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells.
  142. Journal Article Roskams T, Libbrecht L, Van Damme B, Desmet V. Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells?  J. Pathol.  2000;191;2  Link to Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells?
  143. Case ReportsJournal Article Dalle I, Sciot R, de Vos R, Aerts R, van Damme B, Desmet V, Roskams T. Malignant angiomyolipoma of the liver: a hitherto unreported variant.  Histopathology  2000;36;5  Link to Malignant angiomyolipoma of the liver: a hitherto unreported variant.
  144. Congresses Maertens G, Priem S, Ducatteeuw A, Verschoorl E, Verstrepen B, Roskams T, Desmet V, Fuller S, Van Hoek K, Vandeponseele P, Bosman F, Buyse MA, van Doorn LJ, Heeney J, Kos A, Depla E. Improvement of chronic active hepatitis C in chronically infected chimpanzees after therapeutic vaccination with the HCV E1 protein.  Acta Gastroenterol. Belg.  2000;63;2  Link to Improvement of chronic active hepatitis C in chronically infected chimpanzees after therapeutic vaccination with the HCV E1 protein.
  145. Journal Article De Meyer S, Gong ZJ, Hertogs K, Depla E, van Pelt JF, Roskams T, Maertens G, Yap SH. Influence of the administration of human annexin V on in vitro binding of small hepatitis B surface antigen to human and to rat hepatocytes and on in vitro hepatitis B virus infection.  J. Viral Hepat.  2000;7;2  Link to Influence of the administration of human annexin V on in vitro binding of small hepatitis B surface antigen to human and to rat hepatocytes and on in vitro hepatitis B virus infection.

    146. 1999

  146. Journal Article Cassiman D, van Pelt J, De Vos R, Van Lommel F, Desmet V, Yap SH, Roskams T. Synaptophysin: A novel marker for human and rat hepatic stellate cells.  Am. J. Pathol.  1999;155;6  Link to Synaptophysin: A novel marker for human and rat hepatic stellate cells.
  147. Journal Article Christa L, Simon MT, Brezault-Bonnet C, Bonte E, Carnot F, Zylberberg H, Franco D, Capron F, Roskams T, Bréchot C. Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells.  Am. J. Pathol.  1999;155;5  Link to Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells.
  148. Case ReportsLetter Dal Cin P, Van den Berghe H, Van Poppel H, Roskams T. Involvement of 12q12-13 is a nonrandom chromosome change in renal oncocytoma.  Genes Chromosomes Cancer  1999;24;1  Link to Involvement of 12q12-13 is a nonrandom chromosome change in renal oncocytoma.

    149. 1998

  149. Journal Article Gong ZJ, De Meyer S, Roskams T, van Pelt JF, Soumillion A, Crabbé T, Yap SH. Hepatitis B virus infection in microcarrier-attached immortalized human hepatocytes cultured in molecularporous membrane bags: a model for long-term episomal replication of HBV.  J. Viral Hepat.  1998;5;6  Link to Hepatitis B virus infection in microcarrier-attached immortalized human hepatocytes cultured in molecularporous membrane bags: a model for long-term episomal replication of HBV.
  150. Journal ArticleReview Roskams T, Desmet V. Ductular reaction and its diagnostic significance.  Semin Diagn Pathol  1998;15;4  Link to Ductular reaction and its diagnostic significance.
  151. Journal Article Faa G, Van Eyken P, Roskams T, Miyazaki H, Serreli S, Ambu R, Desmet VJ. Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation.  J. Hepatol.  1998;29;4  Link to Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation.
  152. Journal Article Roskams T, De Vos R, Van Eyken P, Myazaki H, Van Damme B, Desmet V. Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man.  J. Hepatol.  1998;29;3  Link to Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man.
  153. Case ReportsJournal Article Robrechts C, De Vos R, Van den Heuvel M, Van Cutsem E, Van Damme B, Desmet V, Roskams T. Primary liver tumour of intermediate (hepatocyte-bile duct cell) phenotype: a progenitor cell tumour?  Liver  1998;18;4  Link to Primary liver tumour of intermediate (hepatocyte-bile duct cell) phenotype: a progenitor cell tumour?
  154. Journal Article Fevery J, Roskams T, Van de Casteele M, Omasta A, Janssens S, Desmet V, Nevens F. NO synthase in the liver: prospects of in vivo gene transfer.  Digestion  1998;59 Suppl 2  Link to NO synthase in the liver: prospects of in vivo gene transfer.
  155. Journal Article Roskams T, De Vos R, David G, Van Damme B, Desmet V. Heparan sulphate proteoglycan expression in human primary liver tumours.  J. Pathol.  1998;185;3  Link to Heparan sulphate proteoglycan expression in human primary liver tumours.
  156. Case ReportsJournal Article Van Steenbergen W, Peeters P, De Bondt J, Staessen D, Büscher H, Laporta T, Roskams T, Desmet V. Nimesulide-induced acute hepatitis: evidence from six cases.  J. Hepatol.  1998;29;1  Link to Nimesulide-induced acute hepatitis: evidence from six cases.
  157. Journal Article Desmet VJ, van Eyken P None, Roskams T. Histopathology of vanishing bile duct diseases.  Adv Clin Path  1998;2;2  Link to Histopathology of vanishing bile duct diseases.

    158. 1997

  158. Journal ArticleReview Roskams T, Desmet V. Parathyroid-hormone-related peptides. A new class of multifunctional proteins.  Am. J. Pathol.  1997;150;3  Link to Parathyroid-hormone-related peptides. A new class of multifunctional proteins.

    159. 1996

  159. Journal Article Roskams T, Rosenbaum J, De Vos R, David G, Desmet V. Heparan sulfate proteoglycan expression in chronic cholestatic human liver diseases.  Hepatology  1996;24;3  Link to Heparan sulfate proteoglycan expression in chronic cholestatic human liver diseases.
  160. Journal Article Roskams T, De Vos R, Desmet V. 'Undifferentiated progenitor cells' in focal nodular hyperplasia of the liver.  Histopathology  1996;28;4  Link to 'Undifferentiated progenitor cells' in focal nodular hyperplasia of the liver.

    161. 1995

  161. Journal Article Roskams T, Moshage H, Depla E, Willems M, Desmet V, Yap P. Parathyroid hormone-related peptide is expressed and rapidly inducible in human liver cell cultures that have a bile duct phenotype.  J. Hepatol.  1995;23;2  Link to Parathyroid hormone-related peptide is expressed and rapidly inducible in human liver cell cultures that have a bile duct phenotype.
  162. Journal ArticleReview Desmet V, Roskams T, Van Eyken P. Ductular reaction in the liver.  Pathol. Res. Pract.  1995;191;6  Link to Ductular reaction in the liver.
  163. Journal Article Roskams T, Moshage H, De Vos R, Guido D, Yap P, Desmet V. Heparan sulfate proteoglycan expression in normal human liver.  Hepatology  1995;21;4  Link to Heparan sulfate proteoglycan expression in normal human liver.

    164. 1994

  164. Journal Article Willems M, Sheng L, Roskams T, Ramdani B, Doutrelepont JM, Nevens F, Durez P, Treille S, Adler M, Desmet V. Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia-related syndrome.  J. Med. Virol.  1994;44;3  Link to Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia-related syndrome.
  165. Case ReportsJournal Article Henckes M, Roskams T, Vanneste S, Van Damme B, Vanrenterghem Y. Polyarteritis nodosa type vasculitis in a patient with familial Mediterranean fever treated with cyclosporin A.  Transpl. Int.  1994;7;4  Link to Polyarteritis nodosa type vasculitis in a patient with familial Mediterranean fever treated with cyclosporin A.

    166. 1993

  166. Journal Article Roskams T, Willems M, Campos RV, Drucker DJ, Yap SH, Desmet VJ. Parathyroid hormone-related peptide expression in primary and metastatic liver tumours.  Histopathology  1993;23;6  Link to Parathyroid hormone-related peptide expression in primary and metastatic liver tumours.
  167. Journal Article Miyazaki H, Van Eyken P, Roskams T, De Vos R, Desmet VJ. Transient expression of tenascin in experimentally induced cholestatic fibrosis in rat liver: an immunohistochemical study.  J. Hepatol.  1993;19;3  Link to Transient expression of tenascin in experimentally induced cholestatic fibrosis in rat liver: an immunohistochemical study.
  168. Journal Article Roskams T, Campos RV, Drucker DJ, Desmet VJ. Reactive human bile ductules express parathyroid hormone-related peptide.  Histopathology  1993;23;1  Link to Reactive human bile ductules express parathyroid hormone-related peptide.
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