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Gores, Gregory J. us

List of all publications

Publishing since 1988 (Dinosaur)

    2010

  1. Journal ArticleResearch Support, N.I.H., Extramural Akazawa Y, Cazanave S, Mott JL, Elmi N, Bronk SF, Kohno S, Charlton MR, Gores GJ. Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis.  J. Hepatol.  2010;52;4  Link to Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis.
  2. Journal ArticleResearch Support, N.I.H., Extramural Smoot RL, Blechacz BR, Werneburg NW, Bronk SF, Sinicrope FA, Sirica AE, Gores GJ. A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells.  Cancer Res.  2010;70;5  Link to A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells.
  3. Journal Article Gores GJ. Academic gastroenterology and hepatology: training tracts and competencies.  Curr. Opin. Gastroenterol.  2010  Link to Academic gastroenterology and hepatology: training tracts and competencies.
  4. Journal ArticlePractice Guideline Chapman R, Fevery J, Kalloo A, Nagorney DM, Boberg KM, Shneider B, Gores GJ. Diagnosis and management of primary sclerosing cholangitis.  Hepatology  2010;51;2  Link to Diagnosis and management of primary sclerosing cholangitis.
  5. Journal ArticleResearch Support, N.I.H., Extramural Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.  J. Clin. Invest.  2010;120;2  Link to Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.

    6. 2009

  6. Journal ArticleResearch Support, N.I.H., Extramural Blechacz BR, Smoot RL, Bronk SF, Werneburg NW, Sirica AE, Gores GJ. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.  Hepatology  2009;50;6  Link to Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.
  7. Journal ArticleMulticenter StudyResearch Support, N.I.H., Extramural Watt KD, Pedersen RA, Kremers WK, Heimbach JK, Sanchez W, Gores GJ. Long-term probability of and mortality from de novo malignancy after liver transplantation.  Gastroenterology  2009;137;6  Link to Long-term probability of and mortality from de novo malignancy after liver transplantation.
  8. Journal ArticleReview Friedman LS, Brandt LJ, Elta GH, Fitz JG, Gores GJ, Katz PO, Kuemmerle JF, Pardi DS, Vargo JJ, Stolar MH. Report of the Multisociety Task Force on GI training.  Gastrointest. Endosc.  2009;70;5  Link to Report of the Multisociety Task Force on GI training.
  9. Consensus Development ConferenceJournal ArticleReview Friedman LS, Brandt LJ, Elta GH, Fitz JG, Gores GJ, Katz PO, Kuemmerle JF, Pardi DS, Vargo JJ, Stolar MH. Report of the Multisociety Task Force on GI training.  Hepatology  2009;50;5  Link to Report of the Multisociety Task Force on GI training.
  10. Journal Article Friedman LS, Brandt LJ, Elta GH, Fitz JG, Gores GJ, Katz PO, Kuemmerle JF, Pardi DS, Vargo JJ, Stolar MH. Report of the multisociety task force on GI training.  Gastroenterology  2009;137;5  Link to Report of the multisociety task force on GI training.
  11. CommentEditorialResearch Support, N.I.H., Extramural Cazanave SC, Gores GJ. The liver's dance with death: two Bcl-2 guardian proteins from the abyss.  Hepatology  2009;50;4  Link to The liver's dance with death: two Bcl-2 guardian proteins from the abyss.
  12. Journal ArticleResearch Support, N.I.H., Extramural Kahraman A, Mott JL, Bronk SF, Werneburg NW, Barreyro FJ, Guicciardi ME, Akazawa Y, Braley K, Craig RW, Gores GJ. Overexpression of mcl-1 attenuates liver injury and fibrosis in the bile duct-ligated mouse.  Dig. Dis. Sci.  2009;54;9  Link to Overexpression of mcl-1 attenuates liver injury and fibrosis in the bile duct-ligated mouse.
  13. Journal Article Beraza N, Malato Y, Sander LE, Al-Masaoudi M, Freimuth J, Riethmacher D, Gores GJ, Roskams T, Liedtke C, Trautwein C. Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.  J. Exp. Med.  2009;206;8  Link to Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
  14. Journal ArticleResearch Support, N.I.H., ExtramuralReview Masuoka HC, Guicciardi ME, Gores GJ. Caspase inhibitors for the treatment of hepatitis C.  Clin Liver Dis  2009;13;3  Link to Caspase inhibitors for the treatment of hepatitis C.
  15. Journal Article Kahraman A, Bronk SF, Cazanave S, Werneburg NW, Mott JL, Contreras PC, Gores GJ. Matrix metalloproteinase inhibitor, CTS-1027, attenuates liver injury and fibrosis in the bile duct-ligated mouse.  Hepatol. Res.  2009;39;8  Link to Matrix metalloproteinase inhibitor, CTS-1027, attenuates liver injury and fibrosis in the bile duct-ligated mouse.
  16. Journal ArticleResearch Support, N.I.H., Extramural Gores GJ. Hepatology: a home for hepatocellular cancer publications.  Hepatology  2009;50;1  Link to Hepatology: a home for hepatocellular cancer publications.
  17. Comparative StudyJournal ArticleResearch Support, N.I.H., Extramural Akazawa Y, Mott JL, Bronk SF, Werneburg NW, Kahraman A, Guicciardi ME, Meng XW, Kohno S, Shah VH, Kaufmann SH, McNiven MA, Gores GJ. Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.  Gastroenterology  2009;136;7  Link to Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.
  18. Comparative StudyEvaluation StudiesJournal Article Fritcher EG, Kipp BR, Halling KC, Oberg TN, Bryant SC, Tarrell RF, Gores GJ, Levy MJ, Clayton AC, Sebo TJ, Roberts LR. A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatobiliary strictures.  Gastroenterology  2009;136;7  Link to A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatobiliary strictures.
  19. Journal ArticleMeta-AnalysisReview Schoenleber SJ, Kurtz DM, Talwalkar JA, Roberts LR, Gores GJ. Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis.  Br. J. Cancer  2009;100;9  Link to Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis.
  20. EditorialResearch Support, N.I.H., Extramural Blechacz BR, Sanchez W, Gores GJ. A conceptual proposal for staging ductal cholangiocarcinoma.  Curr. Opin. Gastroenterol.  2009;25;3  Link to A conceptual proposal for staging ductal cholangiocarcinoma.
  21. Journal ArticleResearch Support, N.I.H., ExtramuralValidation Studies Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H, Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores GJ, LaRusso NF, Hruban R, Meltzer SJ. MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.  Hepatology  2009;49;5  Link to MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.
  22. Journal ArticleReview Rea DJ, Rosen CB, Nagorney DM, Heimbach JK, Gores GJ. Transplantation for cholangiocarcinoma: when and for whom?  Surg. Oncol. Clin. N. Am.  2009;18;2  Link to Transplantation for cholangiocarcinoma: when and for whom?
  23. Journal ArticleResearch Support, N.I.H., Extramural Lleo A, Selmi C, Invernizzi P, Podda M, Coppel RL, Mackay IR, Gores GJ, Ansari AA, Van de Water J, Gershwin ME. Apotopes and the biliary specificity of primary biliary cirrhosis.  Hepatology  2009;49;3  Link to Apotopes and the biliary specificity of primary biliary cirrhosis.
  24. Journal ArticleReview O'Hara SP, Mott JL, Splinter PL, Gores GJ, LaRusso NF. MicroRNAs: key modulators of posttranscriptional gene expression.  Gastroenterology  2009;136;1  Link to MicroRNAs: key modulators of posttranscriptional gene expression.
  25. Journal Article Perry DK, Burns JM, Pollinger HS, Amiot BP, Gloor JM, Gores GJ, Stegall MD. Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production.  Am. J. Transplant.  2009;9;1  Link to Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production.

    26. 2008

  26. Journal Article Gleeson FC, Clayton AC, Zhang L, Clain JE, Gores GJ, Rajan E, Smyrk TC, Topazian MD, Wang KK, Wiersema MJ, Levy MJ. Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease.  Clin. Gastroenterol. Hepatol.  2008;6;12  Link to Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease.
  27. Congresses Sirica AE, Nathanson MH, Gores GJ, Larusso NF. Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference.  Hepatology  2008;48;6  Link to Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference.
  28. Comparative StudyJournal ArticleMulticenter StudyRandomized Controlled TrialResearch Support, N.I.H., Extramural Boetticher NC, Peine CJ, Kwo P, Abrams GA, Patel T, Aqel B, Boardman L, Gores GJ, Harmsen WS, McClain CJ, Kamath PS, Shah VH. A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis.  Gastroenterology  2008;135;6  Link to A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis.
  29. Journal ArticleResearch Support, N.I.H., ExtramuralReview Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease.  Semin. Liver Dis.  2008;28;4  Link to Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease.
  30. Journal ArticleResearch Support, N.I.H., Extramural Decker NK, Abdelmoneim SS, Yaqoob U, Hendrickson H, Hormes J, Bentley M, Pitot H, Urrutia R, Gores GJ, Shah VH. Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver.  Am. J. Pathol.  2008;173;4  Link to Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver.
  31. Congresses Rustgi VK, Davis GL, Herrine SK, McCullough AJ, Friedman SL, Gores GJ. Future trends in hepatology: challenges and opportunities.  Hepatology  2008;48;2  Link to Future trends in hepatology: challenges and opportunities.
  32. CommentEditorialResearch Support, N.I.H., Extramural Blechacz B, Gores GJ. Tumor-specific marker genes for intrahepatic cholangiocarcinoma: utility and mechanistic insight.  J. Hepatol.  2008;49;2  Link to Tumor-specific marker genes for intrahepatic cholangiocarcinoma: utility and mechanistic insight.
  33. Journal ArticleResearch Support, N.I.H., ExtramuralReview Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment.  Hepatology  2008;48;1  Link to Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment.
  34. Journal ArticleResearch Support, N.I.H., Extramural Langer DA, Das A, Semela D, Kang-Decker N, Hendrickson H, Bronk SF, Katusic ZS, Gores GJ, Shah VH. Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species.  Hepatology  2008;47;6  Link to Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species.
  35. Journal ArticleResearch Support, N.I.H., ExtramuralReview Llovet JM, Di Bisceglie AM, Bruix J, Kramer BS, Lencioni R, Zhu AX, Sherman M, Schwartz M, Lotze M, Talwalkar J, Gores GJ. Design and endpoints of clinical trials in hepatocellular carcinoma.  J. Natl. Cancer Inst.  2008;100;10  Link to Design and endpoints of clinical trials in hepatocellular carcinoma.
  36. Comparative StudyJournal ArticleResearch Support, N.I.H., Extramural Levy MJ, Baron TH, Clayton AC, Enders FB, Gostout CJ, Halling KC, Kipp BR, Petersen BT, Roberts LR, Rumalla A, Sebo TJ, Topazian MD, Wiersema MJ, Gores GJ. Prospective evaluation of advanced molecular markers and imaging techniques in patients with indeterminate bile duct strictures.  Am. J. Gastroenterol.  2008;103;5  Link to Prospective evaluation of advanced molecular markers and imaging techniques in patients with indeterminate bile duct strictures.
  37. Journal ArticleReview Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury.  Gastroenterology  2008;134;6  Link to Cellular and molecular mechanisms of liver injury.
  38. EditorialIntroductory Journal ArticleResearch Support, N.I.H., Extramural Gores GJ. A strategic vision to promote advances in biliary tract disorders.  Curr. Opin. Gastroenterol.  2008;24;3  Link to A strategic vision to promote advances in biliary tract disorders.
  39. Journal ArticleResearch Support, N.I.H., Extramural Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity.  Hepatology  2008;47;5  Link to The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity.
  40. Journal ArticleResearch Support, N.I.H., Extramural Kahraman A, Barreyro FJ, Bronk SF, Werneburg NW, Mott JL, Akazawa Y, Masuoka HC, Howe CL, Gores GJ. TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse.  Hepatology  2008;47;4  Link to TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse.
  41. Journal Article Gleeson FC, Rajan E, Levy MJ, Clain JE, Topazian MD, Harewood GC, Papachristou GI, Takahashi N, Rosen CB, Gores GJ. EUS-guided FNA of regional lymph nodes in patients with unresectable hilar cholangiocarcinoma.  Gastrointest. Endosc.  2008;67;3  Link to EUS-guided FNA of regional lymph nodes in patients with unresectable hilar cholangiocarcinoma.
  42. Journal ArticleReview Blechacz BR, Gores GJ. Cholangiocarcinoma.  Clin Liver Dis  2008;12;1  Link to Cholangiocarcinoma.
  43. Editorial Gores GJ. The emergence of a new discipline, hepatobiliary oncology.  Hepatology  2008;47;2  Link to The emergence of a new discipline, hepatobiliary oncology.
  44. Journal Article Rosen CB, Heimbach JK, Gores GJ. Surgery for cholangiocarcinoma: the role of liver transplantation.  HPB (Oxford)  2008;10;3  Link to Surgery for cholangiocarcinoma: the role of liver transplantation.

    45. 2007

  45. Journal ArticleResearch Support, N.I.H., Extramural Baskin-Bey ES, Anan A, Isomoto H, Bronk SF, Gores GJ. Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse.  World J. Gastroenterol.  2007;13;42  Link to Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse.
  46. Journal ArticleResearch Support, N.I.H., ExtramuralReview Akazawa Y, Gores GJ. Death receptor-mediated liver injury.  Semin. Liver Dis.  2007;27;4  Link to Death receptor-mediated liver injury.
  47. CommentEditorial Mott JL, Gores GJ. Targeting IL-6 in cholangiocarcinoma therapy.  Am. J. Gastroenterol.  2007;102;10  Link to Targeting IL-6 in cholangiocarcinoma therapy.
  48. Journal Article Gores GJ, Nagorney DM, Rosen CB. Cholangiocarcinoma: is transplantation an option? For whom?  J. Hepatol.  2007;47;4  Link to Cholangiocarcinoma: is transplantation an option? For whom?
  49. Comparative StudyJournal Article Mantel HT, Rosen CB, Heimbach JK, Nyberg SL, Ishitani MB, Andrews JC, McKusick MA, Haddock MG, Alberts SR, Gores GJ. Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma.  Liver Transpl.  2007;13;10  Link to Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma.
  50. Journal ArticleResearch Support, N.I.H., Extramural Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis.  Oncogene  2007;26;42  Link to mir-29 regulates Mcl-1 protein expression and apoptosis.
  51. Comparative StudyJournal Article Levy MJ, Clain JE, Clayton A, Halling KC, Kipp BR, Rajan E, Roberts LR, Root RM, Sebo TJ, Topazian MD, Wang KK, Wiersema MJ, Gores GJ. Preliminary experience comparing routine cytology results with the composite results of digital image analysis and fluorescence in situ hybridization in patients undergoing EUS-guided FNA.  Gastrointest. Endosc.  2007;66;3  Link to Preliminary experience comparing routine cytology results with the composite results of digital image analysis and fluorescence in situ hybridization in patients undergoing EUS-guided FNA.
  52. Journal ArticleReview Mott JL, Gores GJ. Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death.  Hepatology  2007;46;3  Link to Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death.
  53. Journal Article Barr Fritcher EG, Kipp BR, Slezak JM, Moreno-Luna LE, Gores GJ, Levy MJ, Roberts LR, Halling KC, Sebo TJ. Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy.  Am. J. Clin. Pathol.  2007;128;2  Link to Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy.
  54. Journal ArticleResearch Support, N.I.H., Extramural Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity.  Gut  2007;56;8  Link to Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity.
  55. Journal ArticleReview Alberts SR, Gores GJ, Kim GP, Roberts LR, Kendrick ML, Rosen CB, Chari ST, Martenson JA. Treatment options for hepatobiliary and pancreatic cancer.  Mayo Clin. Proc.  2007;82;5  Link to Treatment options for hepatobiliary and pancreatic cancer.
  56. BiographyHistorical ArticleJournal ArticlePortraits Lazaridis KN, Gores GJ. Our new president--Nicholas F. LaRusso, MD.  Gastroenterology  2007;132;5  Link to Our new president--Nicholas F. LaRusso, MD.
  57. Journal Article Oxentenko AS, Pardi DS, Schmoll JA, Gores GJ. Factors predicting initial career choices in gastroenterology fellows.  J. Clin. Gastroenterol.  2007;41;5  Link to Factors predicting initial career choices in gastroenterology fellows.
  58. Journal ArticleResearch Support, N.I.H., Extramural Guicciardi ME, Bronk SF, Werneburg NW, Gores GJ. cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.  Am. J. Physiol. Gastrointest. Liver Physiol.  2007;292;5  Link to cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.
  59. Journal ArticleResearch Support, N.I.H., Extramural Leerapun A, Suravarapu SV, Bida JP, Clark RJ, Sanders EL, Mettler TA, Stadheim LM, Aderca I, Moser CD, Nagorney DM, LaRusso NF, de Groen PC, Menon KV, Lazaridis KN, Gores GJ, Charlton MR, Roberts RO, Therneau TM, Katzmann JA, Roberts LR. The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population.  Clin. Gastroenterol. Hepatol.  2007;5;3  Link to The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population.
  60. CommentEditorialResearch Support, N.I.H., Extramural Georgiev P, Clavien PA, Gores GJ. Liver graft protection by antiapoptotic drugs: a step further.  Liver Transpl.  2007;13;3  Link to Liver graft protection by antiapoptotic drugs: a step further.
  61. Journal ArticleResearch Support, N.I.H., Extramural Ustundag Y, Bronk SF, Gores GJ. Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells.  World J. Gastroenterol.  2007;13;6  Link to Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells.
  62. Journal ArticleResearch Support, N.I.H., Extramural O'Hara SP, Small AJ, Nelson JB, Badley AD, Chen XM, Gores GJ, Larusso NF. The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.  Infect. Immun.  2007;75;2  Link to The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.
  63. Journal ArticleResearch Support, N.I.H., Extramural Isomoto H, Mott JL, Kobayashi S, Werneburg NW, Bronk SF, Haan S, Gores GJ. Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.  Gastroenterology  2007;132;1  Link to Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
  64. Clinical TrialClinical Trial, Phase IIJournal ArticleMulticenter StudyRandomized Controlled TrialResearch Support, N.I.H., Extramural Baskin-Bey ES, Washburn K, Feng S, Oltersdorf T, Shapiro D, Huyghe M, Burgart L, Garrity-Park M, van Vilsteren FG, Oliver LK, Rosen CB, Gores GJ. Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury.  Am. J. Transplant.  2007;7;1  Link to Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury.

    65. 2006

  65. Journal Article Heimbach JK, Gores GJ, Haddock MG, Alberts SR, Pedersen R, Kremers W, Nyberg SL, Ishitani MB, Rosen CB. Predictors of disease recurrence following neoadjuvant chemoradiotherapy and liver transplantation for unresectable perihilar cholangiocarcinoma.  Transplantation  2006;82;12  Link to Predictors of disease recurrence following neoadjuvant chemoradiotherapy and liver transplantation for unresectable perihilar cholangiocarcinoma.
  66. Journal ArticleResearch Support, N.I.H., Extramural Allina J, Hu B, Sullivan DM, Fiel MI, Thung SN, Bronk SF, Huebert RC, van de Water J, LaRusso NF, Gershwin ME, Gores GJ, Odin JA. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.  J. Autoimmun.  2006;27;4  Link to T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.
  67. Journal ArticleResearch Support, N.I.H., ExtramuralReview Malhi H, Gores GJ. Cholangiocarcinoma: modern advances in understanding a deadly old disease.  J. Hepatol.  2006;45;6  Link to Cholangiocarcinoma: modern advances in understanding a deadly old disease.
  68. Journal Article Gwak GY, Yoon JH, Lee SH, Lee SM, Lee HS, Gores GJ. Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes.  J. Cancer Res. Clin. Oncol.  2006;132;12  Link to Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes.
  69. Journal Article Malhi H, Gores GJ. TRAIL resistance results in cancer progression: a TRAIL to perdition?  Oncogene  2006;25;56  Link to TRAIL resistance results in cancer progression: a TRAIL to perdition?
  70. Journal ArticleResearch Support, N.I.H., Extramural Moreno Luna LE, Gores GJ. Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis.  Liver Transpl.  2006;12;11 Suppl 2  Link to Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis.
  71. Clinical TrialJournal ArticleResearch Support, N.I.H., Extramural Moreno Luna LE, Kipp B, Halling KC, Sebo TJ, Kremers WK, Roberts LR, Barr Fritcher EG, Levy MJ, Gores GJ. Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures.  Gastroenterology  2006;131;4  Link to Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures.
  72. CommentEditorialReview Baskin-Bey ES, Moreno Luna LE, Gores GJ. Diagnosis of cholangiocarcinoma in patients with PSC: a sight on cytology.  J. Hepatol.  2006;45;4  Link to Diagnosis of cholangiocarcinoma in patients with PSC: a sight on cytology.
  73. Journal ArticleResearch Support, N.I.H., Extramural Anan A, Baskin-Bey ES, Isomoto H, Mott JL, Bronk SF, Albrecht JH, Gores GJ. Proteasome inhibition attenuates hepatic injury in the bile duct-ligated mouse.  Am. J. Physiol. Gastrointest. Liver Physiol.  2006;291;4  Link to Proteasome inhibition attenuates hepatic injury in the bile duct-ligated mouse.
  74. Case ReportsJournal Article Bambha K, Nagorney D, Sanderson S, Gores GJ. Hepatic adenomatosis in a young woman with glucose intolerance.  Nature clinical practice. Gastroenterology & hepatology  2006;3;9  Link to Hepatic adenomatosis in a young woman with glucose intolerance.
  75. Clinical ConferenceJournal ArticleReview LaRusso NF, Shneider BL, Black D, Gores GJ, James SP, Doo E, Hoofnagle JH. Primary sclerosing cholangitis: summary of a workshop.  Hepatology  2006;44;3  Link to Primary sclerosing cholangitis: summary of a workshop.
  76. Journal Article Simmons DT, Baron TH, Petersen BT, Gostout CJ, Haddock MG, Gores GJ, Yeakel PD, Topazian MD, Levy MJ. A novel endoscopic approach to brachytherapy in the management of Hilar cholangiocarcinoma.  Am. J. Gastroenterol.  2006;101;8  Link to A novel endoscopic approach to brachytherapy in the management of Hilar cholangiocarcinoma.
  77. Journal Article Varela M, Sanchez W, Bruix J, Gores GJ. Hepatocellular carcinoma in the setting of liver transplantation.  Liver Transpl.  2006;12;7  Link to Hepatocellular carcinoma in the setting of liver transplantation.
  78. Comparative StudyJournal ArticleResearch Support, N.I.H., Extramural Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.  Hepatology  2006;44;1  Link to Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
  79. Journal ArticleResearch Support, N.I.H., Intramural Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.  J. Clin. Invest.  2006;116;7  Link to Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
  80. Journal ArticleResearch Support, N.I.H., Extramural Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization.  Am. J. Physiol. Gastrointest. Liver Physiol.  2006;290;6  Link to Bax inhibition protects against free fatty acid-induced lysosomal permeabilization.
  81. Journal ArticleResearch Support, N.I.H., ExtramuralReview Malhi H, Gores GJ. Review article: the modern diagnosis and therapy of cholangiocarcinoma.  Aliment. Pharmacol. Ther.  2006;23;9  Link to Review article: the modern diagnosis and therapy of cholangiocarcinoma.
  82. Comparative StudyJournal ArticleResearch Support, N.I.H., Extramural van Vilsteren FG, Baskin-Bey ES, Nagorney DM, Sanderson SO, Kremers WK, Rosen CB, Gores GJ, Hobday TJ. Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival.  Liver Transpl.  2006;12;3  Link to Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival.
  83. Journal ArticleResearch Support, N.I.H., Extramural Kim WR, Therneau TM, Benson JT, Kremers WK, Rosen CB, Gores GJ, Dickson ER. Deaths on the liver transplant waiting list: an analysis of competing risks.  Hepatology  2006;43;2  Link to Deaths on the liver transplant waiting list: an analysis of competing risks.
  84. Journal ArticleReview Lazaridis KN, Gores GJ. Primary sclerosing cholangitis and cholangiocarcinoma.  Semin. Liver Dis.  2006;26;1  Link to Primary sclerosing cholangitis and cholangiocarcinoma.
  85. Journal ArticleResearch Support, N.I.H., ExtramuralReview Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis in the liver: a tale of two deaths?  Hepatology  2006;43;2 Suppl 1  Link to Apoptosis and necrosis in the liver: a tale of two deaths?
  86. Journal ArticleResearch Support, N.I.H., Extramural Anan A, Baskin-Bey ES, Bronk SF, Werneburg NW, Shah VH, Gores GJ. Proteasome inhibition induces hepatic stellate cell apoptosis.  Hepatology  2006;43;2  Link to Proteasome inhibition induces hepatic stellate cell apoptosis.
  87. Journal ArticleReview Sanchez W, Talwalkar JA, Gores GJ. "Will all liver transplantation patients eventually die from cancer?".  J. Hepatol.  2006;44;1  Link to "Will all liver transplantation patients eventually die from cancer?".
  88. Journal ArticleResearch Support, N.I.H., Extramural Ishimura N, Isomoto H, Bronk SF, Gores GJ. Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells.  Am. J. Physiol. Gastrointest. Liver Physiol.  2006;290;1  Link to Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells.

    89. 2005

  89. Journal ArticleResearch Support, N.I.H., Extramural Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, Gores GJ. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells.  Hepatology  2005;42;6  Link to Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells.
  90. Journal ArticleResearch Support, N.I.H., ExtramuralReview Baskin-Bey ES, Gores GJ. Death by association: BH3 domain-only proteins and liver injury.  Am. J. Physiol. Gastrointest. Liver Physiol.  2005;289;6  Link to Death by association: BH3 domain-only proteins and liver injury.
  91. Journal Article Wuestefeld T, Klein C, Streetz KL, Beraza N, Schölmerich J, Burgart LJ, Zender L, Kubicka S, Baskin-Bey E, Gores GJ, Manns MP, Trautwein C. Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice.  Hepatology  2005;42;5  Link to Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice.
  92. CommentEditorial Baskin-Bey ES, Gores GJ. Caspase-8, death-receptor signaling, and hepatocarcinogenesis: the Fas and the furious.  Gastroenterology  2005;129;5  Link to Caspase-8, death-receptor signaling, and hepatocarcinogenesis: the Fas and the furious.
  93. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Yu C, Bruzek LM, Meng XW, Gores GJ, Carter CA, Kaufmann SH, Adjei AA. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.  Oncogene  2005;24;46  Link to The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.
  94. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Gawrieh S, Papouchado BG, Burgart LJ, Kobayashi S, Charlton MR, Gores GJ. Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation.  Liver Transpl.  2005;11;10  Link to Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation.
  95. Clinical TrialJournal Article Levy C, Lymp J, Angulo P, Gores GJ, Larusso N, Lindor KD. The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis.  Dig. Dis. Sci.  2005;50;9  Link to The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis.
  96. CommentEditorialResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Anan A, Gores GJ. A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome.  Hepatology  2005;42;3  Link to A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome.
  97. Comparative StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Kim WR, Gores GJ, Benson JT, Therneau TM, Melton LJ. Mortality and hospital utilization for hepatocellular carcinoma in the United States.  Gastroenterology  2005;129;2  Link to Mortality and hospital utilization for hepatocellular carcinoma in the United States.
  98. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Guicciardi ME, Bronk SF, Werneburg NW, Yin XM, Gores GJ. Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.  Gastroenterology  2005;129;1  Link to Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
  99. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review Guicciardi ME, Gores GJ. Apoptosis: a mechanism of acute and chronic liver injury.  Gut  2005;54;7  Link to Apoptosis: a mechanism of acute and chronic liver injury.
  100. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Kobayashi S, Werneburg NW, Bronk SF, Kaufmann SH, Gores GJ. Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.  Gastroenterology  2005;128;7  Link to Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.
  101. Journal ArticleReview Lazaridis KN, Gores GJ. Cholangiocarcinoma.  Gastroenterology  2005;128;6  Link to Cholangiocarcinoma.
  102. Journal Article Ishimura N, Bronk SF, Gores GJ. Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.  Gastroenterology  2005;128;5  Link to Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.
  103. Comparative StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Feldstein AE, Papouchado BG, Angulo P, Sanderson S, Adams L, Gores GJ. Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease.  Clin. Gastroenterol. Hepatol.  2005;3;4  Link to Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease.
  104. Clinical TrialComparative StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Slijkhuis WA, Stadheim L, Hassoun ZM, Nzeako UC, Kremers WK, Talwalkar JA, Gores GJ. Octreotide therapy for advanced hepatocellular carcinoma.  J. Clin. Gastroenterol.  2005;39;4  Link to Octreotide therapy for advanced hepatocellular carcinoma.
  105. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review Stewart CA, Reivich M, Lucey MR, Gores GJ. Neuroimaging in hepatic encephalopathy.  Clin. Gastroenterol. Hepatol.  2005;3;3  Link to Neuroimaging in hepatic encephalopathy.
  106. Comparative StudyJournal Article Harewood GC, Baron TH, Rumalla A, Wang KK, Gores GJ, Stadheim LM, de Groen PC. Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma.  J. Gastroenterol. Hepatol.  2005;20;3  Link to Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma.
  107. Journal Article Gwak GY, Yoon JH, Kim KM, Lee HS, Chung JW, Gores GJ. Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.  J. Hepatol.  2005;42;3  Link to Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.
  108. CommentEditorialResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review Guicciardi ME, Gores GJ. Cholestatic hepatocellular injury: what do we know and how should we proceed.  J. Hepatol.  2005;42;3  Link to Cholestatic hepatocellular injury: what do we know and how should we proceed.
  109. Journal ArticleReview Canbay A, Gieseler RK, Gores GJ, Gerken G. The relationship between apoptosis and non-alcoholic fatty liver disease: an evolutionary cornerstone turned pathogenic.  Z Gastroenterol  2005;43;2  Link to The relationship between apoptosis and non-alcoholic fatty liver disease: an evolutionary cornerstone turned pathogenic.
  110. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Baskin-Bey ES, Canbay A, Bronk SF, Werneburg N, Guicciardi ME, Nyberg SL, Gores GJ. Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury.  Am. J. Physiol. Gastrointest. Liver Physiol.  2005;288;2  Link to Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury.
  111. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Ghobrial IM, Habermann TM, Macon WR, Ristow KM, Larson TS, Walker RC, Ansell SM, Gores GJ, Stegall MD, McGregor CG. Differences between early and late posttransplant lymphoproliferative disorders in solid organ transplant patients: are they two different diseases?  Transplantation  2005;79;2  Link to Differences between early and late posttransplant lymphoproliferative disorders in solid organ transplant patients: are they two different diseases?
  112. Journal Article Baskin-Bey ES, Devarbhavi HC, Nagorney DM, Farnell MB, Donohue JH, Sanderson SO, Stadheim LM, Gores GJ. Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma.  HPB (Oxford)  2005;7;4  Link to Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma.
  113. Journal ArticleReview Roberts LR, Gores GJ. Hepatocellular carcinoma: molecular pathways and new therapeutic targets.  Semin. Liver Dis.  2005;25;2  Link to Hepatocellular carcinoma: molecular pathways and new therapeutic targets.

    114. 2004

  114. Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S. Chiorean MV, Guicciardi ME, Yoon JH, Bronk SF, Kaufmanns SH, Gores GJ. Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells.  Liver Int.  2004;24;6  Link to Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells.
  115. Journal Article Gores GJ, Baskin-Bey ES, Baron TH, Alberts SR. Treatment endpoints for advanced cholangiocarcinoma.  Nature clinical practice. Gastroenterology & hepatology  2004;1;1  Link to Treatment endpoints for advanced cholangiocarcinoma.
  116. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Yoon JH, Gwak GY, Lee HS, Bronk SF, Werneburg NW, Gores GJ. Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells.  J. Hepatol.  2004;41;5  Link to Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells.
  117. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Talwalkar JA, Gores GJ. Diagnosis and staging of hepatocellular carcinoma.  Gastroenterology  2004;127;5 Suppl 1  Link to Diagnosis and staging of hepatocellular carcinoma.
  118. CommentEditorialResearch Support, U.S. Gov't, P.H.S.Review Feldstein AE, Gores GJ. An apoptosis biomarker goes to the HCV clinic.  Hepatology  2004;40;5  Link to An apoptosis biomarker goes to the HCV clinic.
  119. Journal ArticleReview Heimbach JK, Haddock MG, Alberts SR, Nyberg SL, Ishitani MB, Rosen CB, Gores GJ. Transplantation for hilar cholangiocarcinoma.  Liver Transpl.  2004;10;10 Suppl 2  Link to Transplantation for hilar cholangiocarcinoma.
  120. Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S. Kipp BR, Stadheim LM, Halling SA, Pochron NL, Harmsen S, Nagorney DM, Sebo TJ, Therneau TM, Gores GJ, de Groen PC, Baron TH, Levy MJ, Halling KC, Roberts LR. A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures.  Am. J. Gastroenterol.  2004;99;9  Link to A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures.
  121. CommentComparative StudyEditorial Feldstein A, Gores GJ. Steatohepatitis and apoptosis: therapeutic implications.  Am. J. Gastroenterol.  2004;99;9  Link to Steatohepatitis and apoptosis: therapeutic implications.
  122. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Werneburg N, Guicciardi ME, Yin XM, Gores GJ. TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent.  Am. J. Physiol. Gastrointest. Liver Physiol.  2004;287;2  Link to TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent.
  123. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, Burgart LJ, Gores GJ. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway.  Hepatology  2004;40;1  Link to Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway.
  124. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Ishimura N, Bronk SF, Gores GJ. Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth.  Am. J. Physiol. Gastrointest. Liver Physiol.  2004;287;1  Link to Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth.
  125. CommentNews Guicciardi ME, Gores GJ. Cheating death in the liver.  Nat. Med.  2004;10;6  Link to Cheating death in the liver.
  126. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Taniai M, Grambihler A, Higuchi H, Werneburg N, Bronk SF, Farrugia DJ, Kaufmann SH, Gores GJ. Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.  Cancer Res.  2004;64;10  Link to Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
  127. Clinical TrialJournal Article Heimbach JK, Gores GJ, Haddock MG, Alberts SR, Nyberg SL, Ishitani MB, Rosen CB. Liver transplantation for unresectable perihilar cholangiocarcinoma.  Semin. Liver Dis.  2004;24;2  Link to Liver transplantation for unresectable perihilar cholangiocarcinoma.
  128. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Matsumura S, Van De Water J, Leung P, Odin JA, Yamamoto K, Gores GJ, Mostov K, Ansari AA, Coppel RL, Shiratori Y, Gershwin ME. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis.  Hepatology  2004;39;5  Link to Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis.
  129. CommentJournal Article Rosado B, Gores GJ. Liver transplantation for neuroendocrine tumors: progress and uncertainty.  Liver Transpl.  2004;10;5  Link to Liver transplantation for neuroendocrine tumors: progress and uncertainty.
  130. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death.  Oncogene  2004;23;16  Link to Lysosomes in cell death.
  131. Comparative StudyJournal Article Baron TH, Harewood GC, Rumalla A, Pochron NL, Stadheim LM, Gores GJ, Therneau TM, De Groen PC, Sebo TJ, Salomao DR, Kipp BR. A prospective comparison of digital image analysis and routine cytology for the identification of malignancy in biliary tract strictures.  Clin. Gastroenterol. Hepatol.  2004;2;3  Link to A prospective comparison of digital image analysis and routine cytology for the identification of malignancy in biliary tract strictures.
  132. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Yoon JH, Canbay AE, Werneburg NW, Lee SP, Gores GJ. Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis.  Hepatology  2004;39;3  Link to Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis.
  133. Journal Article Strand S, Strand D, Seufert R, Mann A, Lotz J, Blessing M, Lahn M, Wunsch A, Broering DC, Hahn U, Grischke EM, Rogiers X, Otto G, Gores GJ, Galle PR. Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome.  Gastroenterology  2004;126;3  Link to Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome.
  134. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis.  Hepatology  2004;39;2  Link to Apoptosis: the nexus of liver injury and fibrosis.
  135. Clinical TrialJournal ArticleResearch Support, U.S. Gov't, P.H.S. Menon KV, Stadheim L, Kamath PS, Wiesner RH, Gores GJ, Peine CJ, Shah V. A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis.  Am. J. Gastroenterol.  2004;99;2  Link to A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis.

    136. 2003

  136. Journal Article Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice.  J. Hepatol.  2003;39;6  Link to Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice.
  137. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, Gores GJ. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression.  Hepatology  2003;38;5  Link to Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression.
  138. CommentEditorialReview Gores GJ. A spotlight on cholangiocarcinoma.  Gastroenterology  2003;125;5  Link to A spotlight on cholangiocarcinoma.
  139. CommentJournal Article Guicciardi ME, Gores GJ. Targeted use of siRNA in animal models of hepatic damage: an innovative therapy for acute liver failure.  J. Hepatol.  2003;39;5  Link to Targeted use of siRNA in animal models of hepatic damage: an innovative therapy for acute liver failure.
  140. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Janssen HL, Higuchi H, Abdulkarim A, Gores GJ. Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression.  J. Hepatol.  2003;39;3  Link to Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression.
  141. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.  Gastroenterology  2003;125;2  Link to Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.
  142. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Canbay A, Guicciardi ME, Higuchi H, Feldstein A, Bronk SF, Rydzewski R, Taniai M, Gores GJ. Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.  J. Clin. Invest.  2003;112;2  Link to Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.
  143. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Werneburg NW, Yoon JH, Higuchi H, Gores GJ. Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines.  Am. J. Physiol. Gastrointest. Liver Physiol.  2003;285;1  Link to Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines.
  144. Journal Article Stadheim LM, O'Brien JF, Lindor KD, Gores GJ, McGill DB. Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease.  Mayo Clin. Proc.  2003;78;6  Link to Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease.
  145. CommentJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review Guicciardi ME, Gores GJ. AIP1: a new player in TNF signaling.  J. Clin. Invest.  2003;111;12  Link to AIP1: a new player in TNF signaling.
  146. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Canbay A, Taimr P, Torok N, Higuchi H, Friedman S, Gores GJ. Apoptotic body engulfment by a human stellate cell line is profibrogenic.  Lab. Invest.  2003;83;5  Link to Apoptotic body engulfment by a human stellate cell line is profibrogenic.
  147. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Gores GJ. Cholangiocarcinoma: current concepts and insights.  Hepatology  2003;37;5  Link to Cholangiocarcinoma: current concepts and insights.
  148. Case ReportsJournal Article Decker GA, Gores GJ, Roberts LR. Tumor seeding complicating radiofrequency ablation of hepatocellular carcinoma.  J. Hepatol.  2003;38;5  Link to Tumor seeding complicating radiofrequency ablation of hepatocellular carcinoma.
  149. CommentEditorialResearch Support, U.S. Gov't, P.H.S.Review Gores GJ. Cholangiocarcinoma: preventing invasion as anti-cancer strategy.  J. Hepatol.  2003;38;5  Link to Cholangiocarcinoma: preventing invasion as anti-cancer strategy.
  150. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Higuchi H, Gores GJ. Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors.  Am. J. Physiol. Gastrointest. Liver Physiol.  2003;284;5  Link to Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors.
  151. Journal Article Yoon JH, Gores GJ. Diagnosis, Staging, and Treatment of Cholangiocarcinoma.  Curr Treat Options Gastroenterol  2003;6;2  Link to Diagnosis, Staging, and Treatment of Cholangiocarcinoma.
  152. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Natori S, Higuchi H, Contreras P, Gores GJ. The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury.  Liver Transpl.  2003;9;3  Link to The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury.
  153. Clinical TrialClinical Trial, Phase IIJournal ArticleMulticenter Study Leung TW, Yu S, Johnson PJ, Geschwind J, Vogl TJ, Engelmann K, Gores GJ, Giovannini M, O'Grady J, Heneghan M, Stewart M, Orenberg EK, Thuluvath PJ. Phase II study of the efficacy and safety of cisplatin-epinephrine injectable gel administered to patients with unresectable hepatocellular carcinoma.  J. Clin. Oncol.  2003;21;4  Link to Phase II study of the efficacy and safety of cisplatin-epinephrine injectable gel administered to patients with unresectable hepatocellular carcinoma.
  154. Journal Article Gores GJ. Hepatocellular carcinoma: gardening strategies and bridges to transplantation.  Liver Transpl.  2003;9;2  Link to Hepatocellular carcinoma: gardening strategies and bridges to transplantation.
  155. Journal Article Hassoun Z, Gores GJ. Treatment of hepatocellular carcinoma.  Clin. Gastroenterol. Hepatol.  2003;1;1  Link to Treatment of hepatocellular carcinoma.
  156. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Matsushita T, Yagi T, Hardin JA, Cragun JD, Crow FW, Bergen HR, Gores GJ, Nyberg SL. Apoptotic cell death and function of cryopreserved porcine hepatocytes in a bioartificial liver.  Cell Transplant  2003;12;2  Link to Apoptotic cell death and function of cryopreserved porcine hepatocytes in a bioartificial liver.
  157. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Hassoun Z, Gores GJ. What surgeons should know about viral hepatitis and hepatocellular carcinoma.  Surg. Oncol. Clin. N. Am.  2003;12;1  Link to What surgeons should know about viral hepatitis and hepatocellular carcinoma.
  158. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman S, Gores GJ. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis.  Hepatology  2003;37;1  Link to Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis.

    159. 2002

  159. Journal Article Sorom AJ, Nyberg SL, Gores GJ. Keratin, fas, and cryptogenic liver failure.  Liver Transpl.  2002;8;12  Link to Keratin, fas, and cryptogenic liver failure.
  160. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Yoon JH, Werneburg NW, Higuchi H, Canbay AE, Kaufmann SH, Akgul C, Edwards SW, Gores GJ. Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.  Cancer Res.  2002;62;22  Link to Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism.
  161. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Canbay A, Higuchi H, Bronk SF, Taniai M, Sebo TJ, Gores GJ. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.  Gastroenterology  2002;123;4  Link to Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.
  162. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Hassoun Z, Gores GJ, Rosen CB. Preliminary experience with liver transplantation in selected patients with unresectable hilar cholangiocarcinoma.  Surg. Oncol. Clin. N. Am.  2002;11;4  Link to Preliminary experience with liver transplantation in selected patients with unresectable hilar cholangiocarcinoma.
  163. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Taniai M, Higuchi H, Burgart LJ, Gores GJ. p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma.  Gastroenterology  2002;123;4  Link to p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma.
  164. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Werneburg NW, Guicciardi ME, Bronk SF, Gores GJ. Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent.  Am. J. Physiol. Gastrointest. Liver Physiol.  2002;283;4  Link to Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent.
  165. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Yoon JH, Gores GJ. Death receptor-mediated apoptosis and the liver.  J. Hepatol.  2002;37;3  Link to Death receptor-mediated apoptosis and the liver.
  166. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Guicciardi ME, Gores GJ. Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease.  Dig Liver Dis  2002;34;6  Link to Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease.
  167. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Gores GJ. Yes, hepatocellular cancer does occur in primary biliary cirrhosis.  Liver Transpl.  2002;8;6  Link to Yes, hepatocellular cancer does occur in primary biliary cirrhosis.
  168. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Buckles DC, Lindor KD, Larusso NF, Petrovic LM, Gores GJ. In primary sclerosing cholangitis, gallbladder polyps are frequently malignant.  Am. J. Gastroenterol.  2002;97;5  Link to In primary sclerosing cholangitis, gallbladder polyps are frequently malignant.
  169. CommentEditorialReview Guicciardi ME, Gores GJ. Ursodeoxycholic acid cytoprotection: dancing with death receptors and survival pathways.  Hepatology  2002;35;4  Link to Ursodeoxycholic acid cytoprotection: dancing with death receptors and survival pathways.
  170. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Yoon JH, Higuchi H, Werneburg NW, Kaufmann SH, Gores GJ. Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.  Gastroenterology  2002;122;4  Link to Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
  171. CommentLetter Nzeako UC, Gores GJ. Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors.  Cancer  2002;94;6  Link to Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors.
  172. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Török NJ, Higuchi H, Bronk S, Gores GJ. Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9.  Cancer Res.  2002;62;6  Link to Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9.
  173. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Nzeako UC, Guicciardi ME, Yoon JH, Bronk SF, Gores GJ. COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells.  Hepatology  2002;35;3  Link to COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells.
  174. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ. Mechanisms of hepatotoxicity.  Toxicol. Sci.  2002;65;2  Link to Mechanisms of hepatotoxicity.

    175. 2001

  175. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Guicciardi ME, Miyoshi H, Bronk SF, Gores GJ. Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications.  Am. J. Pathol.  2001;159;6  Link to Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications.
  176. Case ReportsJournal Article Gores GJ. Chemoembolization as a bridge to transplantation for hepatocellular carcinoma.  Liver Transpl.  2001;7;11  Link to Chemoembolization as a bridge to transplantation for hepatocellular carcinoma.
  177. Journal ArticleReview Menon KV, Gores GJ, Shah VH. Pathogenesis, diagnosis, and treatment of alcoholic liver disease.  Mayo Clin. Proc.  2001;76;10  Link to Pathogenesis, diagnosis, and treatment of alcoholic liver disease.
  178. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Jaiswal M, LaRusso NF, Nishioka N, Nakabeppu Y, Gores GJ. Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide.  Cancer Res.  2001;61;17  Link to Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide.
  179. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Jaiswal M, LaRusso NF, Gores GJ. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis.  Am. J. Physiol. Gastrointest. Liver Physiol.  2001;281;3  Link to Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis.
  180. Journal Article Higuchi H, Adachi M, Miura S, Gores GJ, Ishii H. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes.  Hepatology  2001;34;2  Link to The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes.
  181. Journal ArticleReview Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.  J. Hepatol.  2001;35;1  Link to Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.
  182. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Gores GJ, Kaufmann SH. Is TRAIL hepatotoxic?  Hepatology  2001;34;1  Link to Is TRAIL hepatotoxic?
  183. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Yagi T, Hardin JA, Valenzuela YM, Miyoshi H, Gores GJ, Nyberg SL. Caspase inhibition reduces apoptotic death of cryopreserved porcine hepatocytes.  Hepatology  2001;33;6  Link to Caspase inhibition reduces apoptotic death of cryopreserved porcine hepatocytes.
  184. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Takikawa Y, Miyoshi H, Rust C, Roberts P, Siegel R, Mandal PK, Millikan RE, Gores GJ. The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes.  Gastroenterology  2001;120;7  Link to The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes.
  185. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Chen XM, Levine SA, Splinter PL, Tietz PS, Ganong AL, Jobin C, Gores GJ, Paya CV, LaRusso NF. Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis.  Gastroenterology  2001;120;7  Link to Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis.
  186. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Souto EO, Miyoshi H, Dubois RN, Gores GJ. Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats.  Am. J. Physiol. Gastrointest. Liver Physiol.  2001;280;5  Link to Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats.
  187. Case ReportsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review Torok N, Gores GJ. Cholangiocarcinoma.  Semin. Gastrointest. Dis.  2001;12;2  Link to Cholangiocarcinoma.
  188. Journal Article Kaya M, de Groen PC, Angulo P, Nagorney DM, Gunderson LL, Gores GJ, Haddock MG, Lindor KD. Treatment of cholangiocarcinoma complicating primary sclerosing cholangitis: the Mayo Clinic experience.  Am. J. Gastroenterol.  2001;96;4  Link to Treatment of cholangiocarcinoma complicating primary sclerosing cholangitis: the Mayo Clinic experience.
  189. Congresses Bissell DM, Gores GJ, Laskin DL, Hoofnagle JH. Drug-induced liver injury: mechanisms and test systems.  Hepatology  2001;33;4  Link to Drug-induced liver injury: mechanisms and test systems.
  190. Case ReportsClinical TrialJournal Article Rumalla A, Baron TH, Wang KK, Gores GJ, Stadheim LM, de Groen PC. Endoscopic application of photodynamic therapy for cholangiocarcinoma.  Gastrointest. Endosc.  2001;53;4  Link to Endoscopic application of photodynamic therapy for cholangiocarcinoma.
  191. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Miyoshi H, Rust C, Guicciardi ME, Gores GJ. NF-kappaB is activated in cholestasis and functions to reduce liver injury.  Am. J. Pathol.  2001;158;3  Link to NF-kappaB is activated in cholestasis and functions to reduce liver injury.
  192. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis.  J. Hepatol.  2001;34;2  Link to Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis.
  193. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Rust C, Gores GJ. Locoregional management of hepatocellular carcinoma. Surgical and ablation therapies.  Clin Liver Dis  2001;5;1  Link to Locoregional management of hepatocellular carcinoma. Surgical and ablation therapies.
  194. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Jaiswal M, LaRusso NF, Shapiro RA, Billiar TR, Gores GJ. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes.  Gastroenterology  2001;120;1  Link to Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes.

    195. 2000

  195. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Higuchi H, Bronk SF, Bateman A, Harrington K, Vile RG, Gores GJ. Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy.  Cancer Res.  2000;60;22  Link to Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy.
  196. Journal ArticleReview Gores GJ. Early detection and treatment of cholangiocarcinoma.  Liver Transpl.  2000;6;6 Suppl 2  Link to Early detection and treatment of cholangiocarcinoma.
  197. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, Kaufmann SH, Gores GJ. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.  J. Clin. Invest.  2000;106;9  Link to Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c.
  198. Journal Article Guicciardi ME, Gores GJ. Dying in Fas traffic.  Hepatology  2000;32;2  Link to Dying in Fas traffic.
  199. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Sodeman T, Bronk SF, Roberts PJ, Miyoshi H, Gores GJ. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.  Am. J. Physiol. Gastrointest. Liver Physiol.  2000;278;6  Link to Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.
  200. Journal Article De Vreede I, Steers JL, Burch PA, Rosen CB, Gunderson LL, Haddock MG, Burgart L, Gores GJ. Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma.  Liver Transpl.  2000;6;3  Link to Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma.
  201. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Rust C, Gores GJ. Apoptosis and liver disease.  Am. J. Med.  2000;108;7  Link to Apoptosis and liver disease.
  202. CommentComparative StudyEditorialReview Llovet JM, Bruix J, Gores GJ. Surgical resection versus transplantation for early hepatocellular carcinoma: clues for the best strategy.  Hepatology  2000;31;4  Link to Surgical resection versus transplantation for early hepatocellular carcinoma: clues for the best strategy.
  203. Journal ArticleReview Ribeiro A, Nagorney DM, Gores GJ. Localized hepatocellular carcinoma: therapeutic options.  Curr Gastroenterol Rep  2000;2;1  Link to Localized hepatocellular carcinoma: therapeutic options.
  204. Journal Article Patel AH, Harnois DM, Klee GG, LaRusso NF, Gores GJ. The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis.  Am. J. Gastroenterol.  2000;95;1  Link to The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis.
  205. CommentEditorialResearch Support, U.S. Gov't, P.H.S. Souto E, Gores GJ. When should a liver mass suspected of being a hepatocellular carcinoma be biopsied?  Liver Transpl.  2000;6;1  Link to When should a liver mass suspected of being a hepatocellular carcinoma be biopsied?
  206. CommentEditorial Rust C, Gores GJ. Hepatocyte transplantation in acute liver failure: a new therapeutic option for the next millennium?  Liver Transpl.  2000;6;1  Link to Hepatocyte transplantation in acute liver failure: a new therapeutic option for the next millennium?
  207. Journal Article Gores GJ. Transforming Power of Immunosuppression: Experimental Mirage or Clinical Mirror to the Future.  Liver Transpl.  2000;6;1  Link to Transforming Power of Immunosuppression: Experimental Mirage or Clinical Mirror to the Future.
  208. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Jaiswal M, LaRusso NF, Burgart LJ, Gores GJ. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.  Cancer Res.  2000;60;1  Link to Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

    209. 1999

  209. Case ReportsJournal Article Lazaridis KN, Gores GJ. Liver mass in a patient with primary sclerosing cholangitis.  J. Hepatol.  1999;31;6  Link to Liver mass in a patient with primary sclerosing cholangitis.
  210. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Ribeiro A, Bronk SF, Roberts PJ, Urrutia R, Gores GJ. The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress.  Hepatology  1999;30;6  Link to The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress.
  211. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Que FG, Phan VA, Phan VH, Celli A, Batts K, LaRusso NF, Gores GJ. Cholangiocarcinomas express Fas ligand and disable the Fas receptor.  Hepatology  1999;30;6  Link to Cholangiocarcinomas express Fas ligand and disable the Fas receptor.
  212. Journal Article Graziadei IW, Wiesner RH, Marotta PJ, Porayko MK, Hay JE, Charlton MR, Poterucha JJ, Rosen CB, Gores GJ, LaRusso NF, Krom RA. Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis.  Hepatology  1999;30;5  Link to Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis.
  213. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Park J, Tadlock L, Gores GJ, Patel T. Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.  Hepatology  1999;30;5  Link to Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line.
  214. Journal ArticleReview de Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM. Biliary tract cancers.  N. Engl. J. Med.  1999;341;18  Link to Biliary tract cancers.
  215. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Chen XM, Gores GJ, Paya CV, LaRusso NF. Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism.  Am. J. Physiol.  1999;277;3 Pt 1  Link to Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas/Fas ligand-dependent mechanism.
  216. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Miyoshi H, Rust C, Roberts PJ, Burgart LJ, Gores GJ. Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.  Gastroenterology  1999;117;3  Link to Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.
  217. Journal Article Patel T, Steer CJ, Gores GJ. Apoptosis and the liver: A mechanism of disease, growth regulation, and carcinogenesis.  Hepatology  1999;30;3  Link to Apoptosis and the liver: A mechanism of disease, growth regulation, and carcinogenesis.
  218. CommentEditorial Rust C, Gores GJ. Does hepatitis C cause liver injury by pathways associated with mitochondrial dysfunction?  Am. J. Gastroenterol.  1999;94;8  Link to Does hepatitis C cause liver injury by pathways associated with mitochondrial dysfunction?
  219. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Natori S, Selzner M, Valentino KL, Fritz LC, Srinivasan A, Clavien PA, Gores GJ. Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism.  Transplantation  1999;68;1  Link to Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism.
  220. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Que FG, Phan VA, Phan VH, LaRusso NF, Gores GJ. GUDC inhibits cytochrome c release from human cholangiocyte mitochondria.  J. Surg. Res.  1999;83;2  Link to GUDC inhibits cytochrome c release from human cholangiocyte mitochondria.
  221. Journal Article Harnois DM, Steers J, Andrews JC, Rubin JC, Pitot HC, Burgart L, Wiesner RH, Gores GJ. Preoperative hepatic artery chemoembolization followed by orthotopic liver transplantation for hepatocellular carcinoma.  Liver Transpl Surg  1999;5;3  Link to Preoperative hepatic artery chemoembolization followed by orthotopic liver transplantation for hepatocellular carcinoma.
  222. Clinical TrialJournal Article Graziadei IW, Wiesner RH, Batts KP, Marotta PJ, LaRusso NF, Porayko MK, Hay JE, Gores GJ, Charlton MR, Ludwig J, Poterucha JJ, Steers JL, Krom RA. Recurrence of primary sclerosing cholangitis following liver transplantation.  Hepatology  1999;29;4  Link to Recurrence of primary sclerosing cholangitis following liver transplantation.
  223. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Park J, Gores GJ, Patel T. Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase.  Hepatology  1999;29;4  Link to Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase.
  224. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Rivera DJ, Gores GJ, Misra SP, Hardin JA, Nyberg SL. Apoptosis by gel-entrapped hepatocytes in a bioartificial liver.  Transplant. Proc.  1999;31;1-2  Link to Apoptosis by gel-entrapped hepatocytes in a bioartificial liver.
  225. Clinical TrialComparative StudyJournal ArticleRandomized Controlled TrialResearch Support, U.S. Gov't, P.H.S. Arora AS, Nichols JC, DeBernardi M, Steers JL, Krom RA, Gores GJ. Glycine rinse protects against liver injury during transplantation.  Transplant. Proc.  1999;31;1-2  Link to Glycine rinse protects against liver injury during transplantation.
  226. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Faubion WA, Guicciardi ME, Miyoshi H, Bronk SF, Roberts PJ, Svingen PA, Kaufmann SH, Gores GJ. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.  J. Clin. Invest.  1999;103;1  Link to Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.
  227. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Faubion WA, Gores GJ. Death receptors in liver biology and pathobiology.  Hepatology  1999;29;1  Link to Death receptors in liver biology and pathobiology.

    228. 1998

  228. Journal Article Kitabayashi K, Gores GJ, Krom RA. Arterial ketone body ratio in clinical liver transplantation.  Transplant. Proc.  1998;30;8  Link to Arterial ketone body ratio in clinical liver transplantation.
  229. Journal Article Guicciardi ME, Gores GJ. Is ursodeoxycholate an antiapoptotic drug?  Hepatology  1998;28;6  Link to Is ursodeoxycholate an antiapoptotic drug?
  230. Congresses Di Bisceglie AM, Carithers RL, Gores GJ. Hepatocellular carcinoma.  Hepatology  1998;28;4  Link to Hepatocellular carcinoma.
  231. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Celli A, Que FG, Gores GJ, LaRusso NF. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes.  Am. J. Physiol.  1998;275;4 Pt 1  Link to Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes.
  232. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Jones B, Roberts PJ, Faubion WA, Kominami E, Gores GJ. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line.  Am. J. Physiol.  1998;275;4 Pt 1  Link to Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line.
  233. CommentEditorial Maher JJ, Gores GJ. Apoptosis: silent killer or neutron bomb?  Hepatology  1998;28;3  Link to Apoptosis: silent killer or neutron bomb?
  234. Comparative StudyJournal Article Ribeiro A, Burgart LJ, Nagorney DM, Gores GJ. Management of liver adenomatosis: results with a conservative surgical approach.  Liver Transpl Surg  1998;4;5  Link to Management of liver adenomatosis: results with a conservative surgical approach.
  235. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Lieser MJ, Park J, Natori S, Jones BA, Bronk SF, Gores GJ. Cholestasis confers resistance to the rat liver mitochondrial permeability transition.  Gastroenterology  1998;115;3  Link to Cholestasis confers resistance to the rat liver mitochondrial permeability transition.
  236. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Jones BA, Gores GJ. Hepatobiliary malignancy.  Clin Liver Dis  1998;2;2  Link to Hepatobiliary malignancy.
  237. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Karnes WE, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, Kaufmann SH. Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells.  Gastroenterology  1998;114;5  Link to Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells.
  238. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Miyoshi H, Gores GJ. Apoptosis and the liver: relevance for the hepato-biliary-pancreatic surgeon.  J Hepatobiliary Pancreat Surg  1998;5;4  Link to Apoptosis and the liver: relevance for the hepato-biliary-pancreatic surgeon.
  239. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Patel T, Roberts LR, Jones BA, Gores GJ. Dysregulation of apoptosis as a mechanism of liver disease: an overview.  Semin. Liver Dis.  1998;18;2  Link to Dysregulation of apoptosis as a mechanism of liver disease: an overview.
  240. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Patel T, Gores GJ. Apoptosis in liver transplantation: a mechanism contributing to immune modulation, preservation injury, neoplasia, and viral disease.  Liver Transpl Surg  1998;4;1  Link to Apoptosis in liver transplantation: a mechanism contributing to immune modulation, preservation injury, neoplasia, and viral disease.

    241. 1997

  241. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Jones BA, Gores GJ. Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine.  Am. J. Physiol.  1997;273;6 Pt 1  Link to Physiology and pathophysiology of apoptosis in epithelial cells of the liver, pancreas, and intestine.
  242. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Roberts LR, Kurosawa H, Bronk SF, Fesmier PJ, Agellon LB, Leung WY, Mao F, Gores GJ. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes.  Gastroenterology  1997;113;5  Link to Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes.
  243. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Harnois DM, Que FG, Celli A, LaRusso NF, Gores GJ. Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line.  Hepatology  1997;26;4  Link to Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line.
  244. Case ReportsClinical TrialControlled Clinical TrialJournal ArticleResearch Support, U.S. Gov't, P.H.S. Harnois DM, Gores GJ, Ludwig J, Steers JL, LaRusso NF, Wiesner RH. Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer?  J. Hepatol.  1997;27;3  Link to Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer?
  245. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Kurosawa H, Que FG, Roberts LR, Fesmier PJ, Gores GJ. Hepatocytes in the bile duct-ligated rat express Bcl-2.  Am. J. Physiol.  1997;272;6 Pt 1  Link to Hepatocytes in the bile duct-ligated rat express Bcl-2.
  246. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, Spelsberg TC, Urrutia R. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.  J. Clin. Invest.  1997;99;10  Link to Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.
  247. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Jones BA, Rao YP, Stravitz RT, Gores GJ. Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C.  Am. J. Physiol.  1997;272;5 Pt 1  Link to Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C.
  248. In VitroJournal ArticleResearch Support, U.S. Gov't, P.H.S. Arora AS, Jones BJ, Patel TC, Bronk SF, Gores GJ. Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat.  Hepatology  1997;25;4  Link to Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat.
  249. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Aguilar HI, Steers JL, Wiesner RH, Krom RA, Gores GJ. Enhanced liver calpain protease activity is a risk factor for dysfunction of human liver allografts.  Transplantation  1997;63;4  Link to Enhanced liver calpain protease activity is a risk factor for dysfunction of human liver allografts.
  250. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Que FG, Gores GJ, LaRusso NF. Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes.  Am. J. Physiol.  1997;272;1 Pt 1  Link to Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes.
  251. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Patel T, Gores GJ. Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E.  Toxicol. Appl. Pharmacol.  1997;142;1  Link to Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E.
  252. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Zeid IM, Bronk SF, Fesmier PJ, Gores GJ. Cytoprotection by fructose and other ketohexoses during bile salt-induced apoptosis of hepatocytes.  Hepatology  1997;25;1  Link to Cytoprotection by fructose and other ketohexoses during bile salt-induced apoptosis of hepatocytes.

    253. 1996

  253. Journal Article Marsman WA, Moore SB, Kondo M, Bundy KL, Gores GJ, Wiesner RH, Krom RA. Do cold agglutinins have any impact on the outcome of liver transplantation?  Transplantation  1996;62;11  Link to Do cold agglutinins have any impact on the outcome of liver transplantation?
  254. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Adjei PN, Kaufmann SH, Leung WY, Mao F, Gores GJ. Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.  J. Clin. Invest.  1996;98;11  Link to Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.
  255. Journal Article Marsman WA, Wiesner RH, Rodriguez L, Batts KP, Porayko MK, Hay JE, Gores GJ, Krom RA. Use of fatty donor liver is associated with diminished early patient and graft survival.  Transplantation  1996;62;9  Link to Use of fatty donor liver is associated with diminished early patient and graft survival.
  256. Comparative StudyJournal Article Laurin J, Lindor KD, Crippin JS, Gossard A, Gores GJ, Ludwig J, Rakela J, McGill DB. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study.  Hepatology  1996;23;6  Link to Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study.
  257. Editorial LaRusso NF, Phillips SF, Bloomer JR, Boland CR, Chang EB, DiMagno EP, Giannella RA, Gores GJ, Malagelada JR, Miller LJ, Rakela J, Szurszewski JH, Binder HJ, Clain JE, LaMont JT, Link AM. Passing the torch: a look back at our editorship.  Gastroenterology  1996;110;5  Link to Passing the torch: a look back at our editorship.
  258. Clinical TrialClinical Trial, Phase IIJournal ArticleResearch Support, U.S. Gov't, P.H.S. Lindor KD, Jorgensen RA, Anderson ML, Gores GJ, Hofmann AF, LaRusso NF. Ursodeoxycholic acid and methotrexate for primary sclerosing cholangitis: a pilot study.  Am. J. Gastroenterol.  1996;91;3  Link to Ursodeoxycholic acid and methotrexate for primary sclerosing cholangitis: a pilot study.
  259. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Aguilar HI, Botla R, Arora AS, Bronk SF, Gores GJ. Induction of the mitochondrial permeability transition by protease activity in rats: a mechanism of hepatocyte necrosis.  Gastroenterology  1996;110;2  Link to Induction of the mitochondrial permeability transition by protease activity in rats: a mechanism of hepatocyte necrosis.

    260. 1995

  260. Clinical TrialComparative StudyJournal ArticleRandomized Controlled Trial Lindor KD, Dickson ER, Jorgensen RA, Anderson ML, Wiesner RH, Gores GJ, Lange SM, Rossi SS, Hofmann AF, Baldus WP. The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study.  Hepatology  1995;22;4 Pt 1  Link to The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study.
  261. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Tan CK, Podila PV, Taylor JE, Nagorney DM, Wiseman GA, Gores GJ, LaRusso NF. Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition.  Gastroenterology  1995;108;6  Link to Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition.
  262. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Kwo P, Patel T, Bronk SF, Gores GJ. Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes.  Am. J. Physiol.  1995;268;4 Pt 1  Link to Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes.

    263. 1994

  263. Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S. Patel T, Bronk SF, Gores GJ. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.  J. Clin. Invest.  1994;94;6  Link to Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.
  264. Comparative StudyJournal Article Spivey JR, Jorgensen RA, Gores GJ, Lindor KD. Methionine-enkephalin concentrations correlate with stage of disease but not pruritus in patients with primary biliary cirrhosis.  Am. J. Gastroenterol.  1994;89;11  Link to Methionine-enkephalin concentrations correlate with stage of disease but not pruritus in patients with primary biliary cirrhosis.
  265. Journal Article Tan CK, Gores GJ, Steers JL, Porayko MK, Hay JE, Rakela J, Wiesner RH, Krom RA. Orthotopic liver transplantation for preoperative early-stage hepatocellular carcinoma.  Mayo Clin. Proc.  1994;69;6  Link to Orthotopic liver transplantation for preoperative early-stage hepatocellular carcinoma.
  266. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Nichols JC, Bronk SF, Mellgren RL, Gores GJ. Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes.  Gastroenterology  1994;106;1  Link to Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes.

    267. 1993

  267. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Roberts SK, Kuntz SM, Gores GJ, LaRusso NF. Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts.  Proc. Natl. Acad. Sci. U.S.A.  1993;90;19  Link to Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts.
  268. Journal Article Nichols JC, Gores GJ, LaRusso NF, Wiesner RH, Nagorney DM, Ritts RE. Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis.  Mayo Clin. Proc.  1993;68;9  Link to Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis.
  269. Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S. Noack K, Bronk SF, Kato A, Gores GJ. The greater vulnerability of bile duct cells to reoxygenation injury than to anoxia. Implications for the pathogenesis of biliary strictures after liver transplantation.  Transplantation  1993;56;3  Link to The greater vulnerability of bile duct cells to reoxygenation injury than to anoxia. Implications for the pathogenesis of biliary strictures after liver transplantation.
  270. In VitroJournal ArticleResearch Support, U.S. Gov't, P.H.S. Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.  J. Clin. Invest.  1993;92;1  Link to Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.
  271. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Bronk SF, Gores GJ. pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes.  Am. J. Physiol.  1993;264;4 Pt 1  Link to pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes.
  272. Clinical TrialComparative StudyJournal Article Wiesner RH, Porayko MK, Wahlstrom HE, Gores GJ, Kamath PS, Hay JE, Krom RA. Early cellular rejection treated with high-dose intravenous corticosteroid therapy is associated with a decrease in the incidence of steroid-resistant rejection and graft failure from rejection.  Transplant. Proc.  1993;25;2  Link to Early cellular rejection treated with high-dose intravenous corticosteroid therapy is associated with a decrease in the incidence of steroid-resistant rejection and graft failure from rejection.
  273. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Dawson TL, Gores GJ, Nieminen AL, Herman B, Lemasters JJ. Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes.  Am. J. Physiol.  1993;264;4 Pt 1  Link to Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes.
  274. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Ferguson DM, Gores GJ, Bronk SF, Krom RA. An increase in cytosolic protease activity during liver preservation. Inhibition by glutathione and glycine.  Transplantation  1993;55;3  Link to An increase in cytosolic protease activity during liver preservation. Inhibition by glutathione and glycine.
  275. Clinical TrialComparative StudyJournal ArticleRandomized Controlled TrialResearch Support, U.S. Gov't, P.H.S. Sanchez-Urdazpal L, Gores GJ, Lemasters JJ, Thurman RG, Steers JL, Wahlstrom HE, Hay EI, Porayko MK, Wiesner RH, Krom RA. Carolina rinse solution decreases liver injury during clinical liver transplantation.  Transplant. Proc.  1993;25;1 Pt 2  Link to Carolina rinse solution decreases liver injury during clinical liver transplantation.

    276. 1992

  276. Journal ArticleReview Wiesner RH, Porayko MK, Dickson ER, Gores GJ, LaRusso NF, Hay JE, Wahlstrom HE, Krom RA. Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis.  Hepatology  1992;16;5  Link to Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis.
  277. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Nieminen AL, Gores GJ, Bond JM, Imberti R, Herman B, Lemasters JJ. A novel cytotoxicity screening assay using a multiwell fluorescence scanner.  Toxicol. Appl. Pharmacol.  1992;115;2  Link to A novel cytotoxicity screening assay using a multiwell fluorescence scanner.
  278. In VitroJournal ArticleResearch Support, U.S. Gov't, P.H.S. Dickson RC, Bronk SF, Gores GJ. Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion.  Gastroenterology  1992;102;6  Link to Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion.
  279. Journal ArticleReview Spivey JR, Gores GJ. Risk factors and screening for hepatocellular carcinoma.  Compr Ther  1992;18;6  Link to Risk factors and screening for hepatocellular carcinoma.
  280. In VitroJournal ArticleResearch Support, U.S. Gov't, P.H.S. Groskreutz JL, Bronk SF, Gores GJ. Ruthenium red delays the onset of cell death during oxidative stress of rat hepatocytes.  Gastroenterology  1992;102;3  Link to Ruthenium red delays the onset of cell death during oxidative stress of rat hepatocytes.

    281. 1991

  281. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Bronk SF, Gores GJ. Efflux of protons from acidic vesicles contributes to cytosolic acidification of hepatocytes during ATP depletion.  Hepatology  1991;14;4 Pt 1  Link to Efflux of protons from acidic vesicles contributes to cytosolic acidification of hepatocytes during ATP depletion.
  282. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Bronk SF, Gores GJ. Acidosis protects against lethal oxidative injury of liver sinusoidal endothelial cells.  Hepatology  1991;14;1  Link to Acidosis protects against lethal oxidative injury of liver sinusoidal endothelial cells.
  283. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Takei Y, Marzi I, Gao WS, Gores GJ, Lemasters JJ, Thurman RG. Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat.  Transplantation  1991;51;5  Link to Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat.
  284. Journal Article van Hoek B, Wiesner RH, Ludwig J, Gores GJ, Moore B, Krom RA. Combination immunosuppression with azathioprine reduces the incidence of ductopenic rejection and vanishing bile duct syndrome after liver transplantation.  Transplant. Proc.  1991;23;1 Pt 2  Link to Combination immunosuppression with azathioprine reduces the incidence of ductopenic rejection and vanishing bile duct syndrome after liver transplantation.

    285. 1990

  285. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Kost LJ, Gores GJ, Sayles JM, Miller LJ, Lemasters JJ, Herman B, LaRusso NF. Lack of metabolic effects of cholecystokinin on hepatocytes.  Hepatology  1990;12;2  Link to Lack of metabolic effects of cholecystokinin on hepatocytes.
  286. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Marzi I, Takei Y, Knee J, Menger M, Gores GJ, Bühren V, Trentz O, Lemasters JJ, Thurman RG. Assessment of reperfusion injury by intravital fluorescence microscopy following liver transplantation in the rat.  Transplant. Proc.  1990;22;4  Link to Assessment of reperfusion injury by intravital fluorescence microscopy following liver transplantation in the rat.
  287. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Gores GJ, Herman B, Lemasters JJ. Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury.  Hepatology  1990;11;4  Link to Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury.

    288. 1989

  288. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Gores GJ, Kost LJ, Miller LJ, LaRusso NF. Processing of cholecystokinin by isolated liver cells.  Am. J. Physiol.  1989;257;2 Pt 1  Link to Processing of cholecystokinin by isolated liver cells.
  289. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Gores GJ, Flarsheim CE, Dawson TL, Nieminen AL, Herman B, Lemasters JJ. Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes.  Am. J. Physiol.  1989;257;2 Pt 1  Link to Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes.
  290. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Gores GJ, Nieminen AL, Wray BE, Herman B, Lemasters JJ. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.  J. Clin. Invest.  1989;83;2  Link to Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

    291. 1988

  291. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Gores GJ, Nieminen AL, Fleishman KE, Dawson TL, Herman B, Lemasters JJ. Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes.  Am. J. Physiol.  1988;255;3 Pt 1  Link to Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes.
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