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Friedman, Scott L. us

List of all publications

Publishing since 1988 (Dinosaur)

    2010

  1. In VitroJournal ArticleResearch Support, N.I.H., Extramural Lee UE, Ghiassi-Nejad Z, Paris AJ, Yea S, Narla G, Walsh M, Friedman SL. Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.  FEBS Lett.  2010;584;5  Link to Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.
  2. Journal Article Lee TF, Mak KM, Rackovsky O, Lin YL, Kwong AJ, Loke JC, Friedman SL. Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP).  J. Cell. Physiol.  2010;223;3  Link to Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP).

    3. 2009

  3. Journal ArticleResearch Support, N.I.H., Extramural Tan HH, Fiel MI, Sun Q, Guo J, Gordon RE, Chen LC, Friedman SL, Odin JA, Allina J. Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease.  J Immunotoxicol  2009;6;4  Link to Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease.
  4. Journal ArticleResearch Support, N.I.H., Extramural Liu Y, Wen XM, Lui EL, Friedman SL, Cui W, Ho NP, Li L, Ye T, Fan ST, Zhang H. Therapeutic targeting of the PDGF and TGF-beta-signaling pathways in hepatic stellate cells by PTK787/ZK22258.  Lab. Invest.  2009;89;10  Link to Therapeutic targeting of the PDGF and TGF-beta-signaling pathways in hepatic stellate cells by PTK787/ZK22258.
  5. Journal ArticleResearch Support, N.I.H., Extramural Newell P, Toffanin S, Villanueva A, Chiang DY, Minguez B, Cabellos L, Savic R, Hoshida Y, Lim KH, Melgar-Lesmes P, Yea S, Peix J, Deniz K, Fiel MI, Thung S, Alsinet C, Tovar V, Mazzaferro V, Bruix J, Roayaie S, Schwartz M, Friedman SL, Llovet JM. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.  J. Hepatol.  2009;51;4  Link to Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.
  6. Journal Article Li Y, Chang M, Abar O, Garcia V, Rowland C, Catanese J, Ross D, Broder S, Shiffman M, Cheung R, Wright T, Friedman SL, Sninsky J. Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.  J. Hepatol.  2009;51;4  Link to Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.
  7. Journal Article Tan HH, Fiel MI, Sun Q, Guo J, Gordon RE, Chen LC, Friedman SL, Odin JA, Allina J. Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease.  J Immunotoxicol  2009  Link to Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease.
  8. Journal ArticleResearch Support, N.I.H., Extramural Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, Watanabe G, Gabriel S, Friedman SL, Kumada H, Llovet JM, Golub TR. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.  Cancer Res.  2009;69;18  Link to Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.
  9. Journal ArticleResearch Support, N.I.H., Extramural Wasmuth HE, Lammert F, Zaldivar MM, Weiskirchen R, Hellerbrand C, Scholten D, Berres ML, Zimmermann H, Streetz KL, Tacke F, Hillebrandt S, Schmitz P, Keppeler H, Berg T, Dahl E, Gassler N, Friedman SL, Trautwein C. Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.  Gastroenterology  2009;137;1  Link to Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.
  10. Journal Article Bechmann LP, Zahn D, Gieseler RK, Fingas CD, Marquitan G, Jochum C, Gerken G, Friedman SL, Canbay A. Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells.  Hepatol. Res.  2009;39;6  Link to Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells.
  11. Journal ArticleReview Jiao J, Friedman SL, Aloman C. Hepatic fibrosis.  Curr. Opin. Gastroenterol.  2009;25;3  Link to Hepatic fibrosis.
  12. Journal ArticleResearch Support, N.I.H., Extramural Mölleken C, Sitek B, Henkel C, Poschmann G, Sipos B, Wiese S, Warscheid B, Broelsch C, Reiser M, Friedman SL, Tornøe I, Schlosser A, Klöppel G, Schmiegel W, Meyer HE, Holmskov U, Stühler K. Detection of novel biomarkers of liver cirrhosis by proteomic analysis.  Hepatology  2009;49;4  Link to Detection of novel biomarkers of liver cirrhosis by proteomic analysis.
  13. Journal ArticleResearch Support, N.I.H., Extramural Sangodkar J, Shi J, DiFeo A, Schwartz R, Bromberg R, Choudhri A, McClinch K, Hatami R, Scheer E, Kremer-Tal S, Martignetti JA, Hui A, Leung WK, Friedman SL, Narla G. Functional role of the KLF6 tumour suppressor gene in gastric cancer.  Eur. J. Cancer  2009;45;4  Link to Functional role of the KLF6 tumour suppressor gene in gastric cancer.
  14. Journal ArticleResearch Support, N.I.H., Extramural Guo J, Loke J, Zheng F, Hong F, Yea S, Fukata M, Tarocchi M, Abar OT, Huang H, Sninsky JJ, Friedman SL. Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.  Hepatology  2009;49;3  Link to Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.
  15. Journal ArticleResearch Support, N.I.H., Extramural Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST. PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling.  Lab. Invest.  2009;89;2  Link to PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling.
  16. Journal Article Friedman SL, McCullough A, Gores G. Commentary: Gastroenterology and hepatology: an evolving marriage, not an imminent divorce.  Am. J. Gastroenterol.  2009;104;1  Link to Commentary: Gastroenterology and hepatology: an evolving marriage, not an imminent divorce.
  17. Journal ArticleResearch Support, N.I.H., Extramural Jameel NM, Thirunavukkarasu C, Wu T, Watkins SC, Friedman SL, Gandhi CR. p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid.  J. Cell. Physiol.  2009;218;1  Link to p38-MAPK- and caspase-3-mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid.

    18. 2008

  18. Journal ArticleResearch Support, N.I.H., ExtramuralReview Friedman SL. Hepatic fibrosis -- overview.  Toxicology  2008;254;3  Link to Hepatic fibrosis -- overview.
  19. Journal ArticleReview Ghiassi-Nejad Z, Friedman SL. Advances in antifibrotic therapy.  Expert review of gastroenterology & hepatology  2008;2;6  Link to Advances in antifibrotic therapy.
  20. Comparative StudyJournal ArticleMulticenter StudyResearch Support, N.I.H., Extramural Villanueva A, Chiang DY, Newell P, Peix J, Thung S, Alsinet C, Tovar V, Roayaie S, Minguez B, Sole M, Battiston C, Van Laarhoven S, Fiel MI, Di Feo A, Hoshida Y, Yea S, Toffanin S, Ramos A, Martignetti JA, Mazzaferro V, Bruix J, Waxman S, Schwartz M, Meyerson M, Friedman SL, Llovet JM. Pivotal role of mTOR signaling in hepatocellular carcinoma.  Gastroenterology  2008;135;6  Link to Pivotal role of mTOR signaling in hepatocellular carcinoma.
  21. Journal ArticleResearch Support, N.I.H., Extramural Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang DY, Camargo A, Gupta S, Moore J, Wrobel MJ, Lerner J, Reich M, Chan JA, Glickman JN, Ikeda K, Hashimoto M, Watanabe G, Daidone MG, Roayaie S, Schwartz M, Thung S, Salvesen HB, Gabriel S, Mazzaferro V, Bruix J, Friedman SL, Kumada H, Llovet JM, Golub TR. Gene expression in fixed tissues and outcome in hepatocellular carcinoma.  N. Engl. J. Med.  2008;359;19  Link to Gene expression in fixed tissues and outcome in hepatocellular carcinoma.
  22. Introductory Journal Article Friedman SL. Preface. Hepatic fibrosis: pathogenesis, diagnosis, and emerging therapies.  Clin Liver Dis  2008;12;4  Link to Preface. Hepatic fibrosis: pathogenesis, diagnosis, and emerging therapies.
  23. Journal ArticleResearch Support, N.I.H., Extramural Muhanna N, Doron S, Wald O, Horani A, Eid A, Pappo O, Friedman SL, Safadi R. Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis.  Hepatology  2008;48;3  Link to Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis.
  24. Journal ArticleResearch Support, N.I.H., Extramural Hartel M, Narla G, Wente MN, Giese NA, Martignoni ME, Martignetti JA, Friess H, Friedman SL. Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer.  Eur. J. Cancer  2008;44;13  Link to Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer.
  25. Journal ArticleResearch Support, N.I.H., Extramural Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, Minguez B, LeBlanc AC, Donovan DJ, Thung SN, Solé M, Tovar V, Alsinet C, Ramos AH, Barretina J, Roayaie S, Schwartz M, Waxman S, Bruix J, Mazzaferro V, Ligon AH, Najfeld V, Friedman SL, Sellers WR, Meyerson M, Llovet JM. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.  Cancer Res.  2008;68;16  Link to Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.
  26. Congresses Rustgi VK, Davis GL, Herrine SK, McCullough AJ, Friedman SL, Gores GJ. Future trends in hepatology: challenges and opportunities.  Hepatology  2008;48;2  Link to Future trends in hepatology: challenges and opportunities.
  27. Journal ArticleResearch Support, N.I.H., Extramural Narla G, DiFeo A, Fernandez Y, Dhanasekaran S, Huang F, Sangodkar J, Hod E, Leake D, Friedman SL, Hall SJ, Chinnaiyan AM, Gerald WL, Rubin MA, Martignetti JA. KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.  J. Clin. Invest.  2008;118;8  Link to KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
  28. Journal ArticleResearch Support, N.I.H., Extramural Miele L, Beale G, Patman G, Nobili V, Leathart J, Grieco A, Abate M, Friedman SL, Narla G, Bugianesi E, Day CP, Reeves HL. The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease.  Gastroenterology  2008;135;1  Link to The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease.
  29. Journal ArticleResearch Support, N.I.H., ExtramuralReview Friedman SL. Mechanisms of hepatic fibrogenesis.  Gastroenterology  2008;134;6  Link to Mechanisms of hepatic fibrogenesis.
  30. Comparative StudyJournal ArticleResearch Support, N.I.H., Extramural Yea S, Narla G, Zhao X, Garg R, Tal-Kremer S, Hod E, Villanueva A, Loke J, Tarocchi M, Akita K, Shirasawa S, Sasazuki T, Martignetti JA, Llovet JM, Friedman SL. Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.  Gastroenterology  2008;134;5  Link to Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.
  31. Journal ArticleResearch Support, N.I.H., ExtramuralReview Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM. Experimental models of hepatocellular carcinoma.  J. Hepatol.  2008;48;5  Link to Experimental models of hepatocellular carcinoma.
  32. Journal Article Cristol DA, Brasso RL, Condon AM, Fovargue RE, Friedman SL, Hallinger KK, Monroe AP, White AE. The movement of aquatic mercury through terrestrial food webs.  Science  2008;320;5874  Link to The movement of aquatic mercury through terrestrial food webs.
  33. Journal ArticleResearch Support, N.I.H., Extramural Higazi AA, El-Haj M, Melhem A, Horani A, Pappo O, Alvarez CE, Muhanna N, Friedman SL, Safadi R. Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis.  Clin. Exp. Immunol.  2008;152;1  Link to Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis.
  34. Journal Article Bentov I, Narla G, Schayek H, Akita K, Plymate SR, LeRoith D, Friedman SL, Werner H. Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.  Endocrinology  2008;149;4  Link to Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.
  35. CommentJournal Article Friedman SL, Nieto N. Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.  Cell Metab.  2008;7;3  Link to Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.
  36. Journal ArticleResearch Support, N.I.H., ExtramuralReview Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.  Physiol. Rev.  2008;88;1  Link to Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.

    37. 2007

  37. Journal ArticleResearch Support, N.I.H., Extramural Tugues S, Fernandez-Varo G, Muñoz-Luque J, Ros J, Arroyo V, Rodés J, Friedman SL, Carmeliet P, Jiménez W, Morales-Ruiz M. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.  Hepatology  2007;46;6  Link to Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.
  38. CommentNews Friedman SL. A deer in the headlights: BAMBI meets liver fibrosis.  Nat. Med.  2007;13;11  Link to A deer in the headlights: BAMBI meets liver fibrosis.
  39. Journal ArticleResearch Support, N.I.H., ExtramuralReview Guo J, Friedman SL. Hepatic fibrogenesis.  Semin. Liver Dis.  2007;27;4  Link to Hepatic fibrogenesis.
  40. Journal Article Teixeira MS, Camacho-Vanegas O, Fernandez Y, Narla G, DiFeo A, Lee B, Kalir T, Friedman SL, Schlecht NF, Genden EM, Urken M, Brandwein-Gensler M, Martignetti JA. KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.  Int. J. Cancer  2007;121;9  Link to KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.
  41. Editorial Friedman SL. Liver fibrosis: from mechanisms to treatment.  Gastroenterol. Clin. Biol.  2007;31;10  Link to Liver fibrosis: from mechanisms to treatment.
  42. Journal Article Camacho-Vanegas O, Narla G, Teixeira MS, DiFeo A, Misra A, Singh G, Chan AM, Friedman SL, Feuerstein BG, Martignetti JA. Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.  Int. J. Cancer  2007;121;6  Link to Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.
  43. Journal ArticleMulticenter StudyResearch Support, N.I.H., Extramural O'Brien M, Nader PR, Houts RM, Bradley R, Friedman SL, Belsky J, Susman E. The ecology of childhood overweight: a 12-year longitudinal analysis.  Int J Obes (Lond)  2007;31;9  Link to The ecology of childhood overweight: a 12-year longitudinal analysis.
  44. Journal Article Teixeira R, Marcos LA, Friedman SL. Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C.  Hepatol. Res.  2007;37;8  Link to Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C.
  45. Journal ArticleResearch Support, N.I.H., Extramural Narla G, Kremer-Tal S, Matsumoto N, Zhao X, Yao S, Kelley K, Tarocchi M, Friedman SL. In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma.  Oncogene  2007;26;30  Link to In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma.
  46. Journal Article Friedman SL. Reversibility of hepatic fibrosis and cirrhosis--is it all hype?  Nature clinical practice. Gastroenterology & hepatology  2007;4;5  Link to Reversibility of hepatic fibrosis and cirrhosis--is it all hype?
  47. Journal ArticleResearch Support, N.I.H., Extramural Kinoshita K, Iimuro Y, Otogawa K, Saika S, Inagaki Y, Nakajima Y, Kawada N, Fujimoto J, Friedman SL, Ikeda K. Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.  Gut  2007;56;5  Link to Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats.
  48. Journal ArticleResearch Support, N.I.H., Extramural Kremer-Tal S, Narla G, Chen Y, Hod E, DiFeo A, Yea S, Lee JS, Schwartz M, Thung SN, Fiel IM, Banck M, Zimran E, Thorgeirsson SS, Mazzaferro V, Bruix J, Martignetti JA, Llovet JM, Friedman SL. Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.  J. Hepatol.  2007;46;4  Link to Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.
  49. Journal ArticleResearch Support, N.I.H., Extramural Kinoshita K, Iimuro Y, Fujimoto J, Inagaki Y, Namikawa K, Kiyama H, Nakajima Y, Otogawa K, Kawada N, Friedman SL, Ikeda K. Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.  Gut  2007;56;3  Link to Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis.
  50. Journal ArticleResearch Support, N.I.H., ExtramuralReview Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. Genomics and signaling pathways in hepatocellular carcinoma.  Semin. Liver Dis.  2007;27;1  Link to Genomics and signaling pathways in hepatocellular carcinoma.
  51. Journal Article Horani A, Muhanna N, Pappo O, Melhem A, Alvarez CE, Doron S, Wehbi W, Dimitrios K, Friedman SL, Safadi R. Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis.  Am. J. Physiol. Gastrointest. Liver Physiol.  2007;292;2  Link to Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis.
  52. Congresses Friedman SL, Rockey DC, Bissell DM. Hepatic fibrosis 2006: report of the Third AASLD Single Topic Conference.  Hepatology  2007;45;1  Link to Hepatic fibrosis 2006: report of the Third AASLD Single Topic Conference.
  53. CommentJournal Article Friedman SL. Reefer madness? Assessing the effects of cannabinoids with a less jaundiced eye.  J. Hepatol.  2007;46;1  Link to Reefer madness? Assessing the effects of cannabinoids with a less jaundiced eye.

    54. 2006

  54. Journal ArticleResearch Support, N.I.H., Extramural Banck MS, Beaven SW, Narla G, Walsh MJ, Friedman SL, Beutler AS. KLF6 degradation after apoptotic DNA damage.  FEBS Lett.  2006;580;30  Link to KLF6 degradation after apoptotic DNA damage.
  55. Journal ArticleResearch Support, N.I.H., Extramural Llovet JM, Chen Y, Wurmbach E, Roayaie S, Fiel MI, Schwartz M, Thung SN, Khitrov G, Zhang W, Villanueva A, Battiston C, Mazzaferro V, Bruix J, Waxman S, Friedman SL. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.  Gastroenterology  2006;131;6  Link to A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.
  56. Journal ArticleResearch Support, N.I.H., ExtramuralReview Albanis E, Friedman SL. Diagnosis of hepatic fibrosis in patients with chronic hepatitis C.  Clin Liver Dis  2006;10;4  Link to Diagnosis of hepatic fibrosis in patients with chronic hepatitis C.
  57. Journal ArticleResearch Support, N.I.H., ExtramuralReview Lemmer ER, Friedman SL, Llovet JM. Molecular diagnosis of chronic liver disease and hepatocellular carcinoma: the potential of gene expression profiling.  Semin. Liver Dis.  2006;26;4  Link to Molecular diagnosis of chronic liver disease and hepatocellular carcinoma: the potential of gene expression profiling.
  58. Journal ArticleReview Friedman SL. Transcriptional regulation of stellate cell activation.  J. Gastroenterol. Hepatol.  2006;21 Suppl 3  Link to Transcriptional regulation of stellate cell activation.
  59. Journal Article DiFeo A, Narla G, Camacho-Vanegas O, Nishio H, Rose SL, Buller RE, Friedman SL, Walsh MJ, Martignetti JA. E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor.  Oncogene  2006;25;44  Link to E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor.
  60. Journal ArticleResearch Support, N.I.H., Extramural Melhem A, Muhanna N, Bishara A, Alvarez CE, Ilan Y, Bishara T, Horani A, Nassar M, Friedman SL, Safadi R. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.  J. Hepatol.  2006;45;1  Link to Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.
  61. Journal Article DiFeo A, Narla G, Hirshfeld J, Camacho-Vanegas O, Narla J, Rose SL, Kalir T, Yao S, Levine A, Birrer MJ, Bonome T, Friedman SL, Buller RE, Martignetti JA. Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.  Clin. Cancer Res.  2006;12;12  Link to Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.
  62. Journal ArticleResearch Support, N.I.H., Extramural Zhan SS, Jiang JX, Wu J, Halsted C, Friedman SL, Zern MA, Torok NJ. Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo.  Hepatology  2006;43;3  Link to Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo.
  63. Journal ArticleResearch Support, N.I.H., Extramural Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, Friedman SL. Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.  Blood  2006;107;4  Link to Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.
  64. Journal ArticleReview Friedman SL, Bansal MB. Reversal of hepatic fibrosis -- fact or fantasy?  Hepatology  2006;43;2 Suppl 1  Link to Reversal of hepatic fibrosis -- fact or fantasy?
  65. Journal Article Kirschenbaum A, Liu XH, Yao S, Narla G, Friedman SL, Martignetti JA, Levine AC. Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.  Carcinogenesis  2006;27;2  Link to Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.
  66. Journal ArticleReview Albanis E, Friedman SL. Antifibrotic agents for liver disease.  Am. J. Transplant.  2006;6;1  Link to Antifibrotic agents for liver disease.

    67. 2005

  67. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL. Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.  Cancer Res.  2005;65;20  Link to Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.
  68. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Safadi R, Alvarez CE, Ohta M, Brimnes J, Kraus T, Mehal W, Bromberg J, Mayer L, Friedman SL. Enhanced oral tolerance in transgenic mice with hepatocyte secretion of IL-10.  J. Immunol.  2005;175;6  Link to Enhanced oral tolerance in transgenic mice with hepatocyte secretion of IL-10.
  69. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Narla G, DiFeo A, Yao S, Banno A, Hod E, Reeves HL, Qiao RF, Camacho-Vanegas O, Levine A, Kirschenbaum A, Chan AM, Friedman SL, Martignetti JA. Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.  Cancer Res.  2005;65;13  Link to Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.
  70. In VitroJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. van de Bovenkamp M, Groothuis GM, Draaisma AL, Merema MT, Bezuijen JI, van Gils MJ, Meijer DK, Friedman SL, Olinga P. Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.  Toxicol. Sci.  2005;85;1  Link to Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu.
  71. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S. Bansal MB, Kovalovich K, Gupta R, Li W, Agarwal A, Radbill B, Alvarez CE, Safadi R, Fiel MI, Friedman SL, Taub RA. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.  J. Hepatol.  2005;42;4  Link to Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
  72. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Narla G, Difeo A, Reeves HL, Schaid DJ, Hirshfeld J, Hod E, Katz A, Isaacs WB, Hebbring S, Komiya A, McDonnell SK, Wiley KE, Jacobsen SJ, Isaacs SD, Walsh PC, Zheng SL, Chang BL, Friedrichsen DM, Stanford JL, Ostrander EA, Chinnaiyan AM, Rubin MA, Xu J, Thibodeau SN, Friedman SL, Martignetti JA. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.  Cancer Res.  2005;65;4  Link to A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.
  73. CommentJournal Article Friedman SL. Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis.  J. Clin. Invest.  2005;115;1  Link to Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis.
  74. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Xu L, Hui AY, Albanis E, Arthur MJ, O'Byrne SM, Blaner WS, Mukherjee P, Friedman SL, Eng FJ. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.  Gut  2005;54;1  Link to Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.

    75. 2004

  75. Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications.  Nature clinical practice. Gastroenterology & hepatology  2004;1;2  Link to Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications.
  76. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Wandzioch E, Kolterud A, Jacobsson M, Friedman SL, Carlsson L. Lhx2-/- mice develop liver fibrosis.  Proc. Natl. Acad. Sci. U.S.A.  2004;101;47  Link to Lhx2-/- mice develop liver fibrosis.
  77. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Kremer-Tal S, Reeves HL, Narla G, Thung SN, Schwartz M, Difeo A, Katz A, Bruix J, Bioulac-Sage P, Martignetti JA, Friedman SL. Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.  Hepatology  2004;40;5  Link to Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.
  78. CommentEditorialReview Friedman SL. Stellate cells: a moving target in hepatic fibrogenesis.  Hepatology  2004;40;5  Link to Stellate cells: a moving target in hepatic fibrogenesis.
  79. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Wang X, Tang X, Gong X, Albanis E, Friedman SL, Mao Z. Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2.  Gastroenterology  2004;127;4  Link to Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2.
  80. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Tang S, Bhatia B, Zhou J, Maldonado CJ, Chandra D, Kim E, Fischer SM, Butler AP, Friedman SL, Tang DG. Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.  Oncogene  2004;23;41  Link to Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.
  81. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, Friedman SL. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes.  Gastroenterology  2004;127;3  Link to Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes.
  82. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Hui AY, Dannenberg AJ, Sung JJ, Subbaramaiah K, Du B, Olinga P, Friedman SL. Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells.  J. Hepatol.  2004;41;2  Link to Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells.
  83. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Rubinstein M, Idelman G, Plymate SR, Narla G, Friedman SL, Werner H. Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.  Endocrinology  2004;145;8  Link to Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.
  84. Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S. Kimmelman AC, Qiao RF, Narla G, Banno A, Lau N, Bos PD, Nuñez Rodriguez N, Liang BC, Guha A, Martignetti JA, Friedman SL, Chan AM. Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.  Oncogene  2004;23;29  Link to Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.
  85. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Benzeno S, Narla G, Allina J, Cheng GZ, Reeves HL, Banck MS, Odin JA, Diehl JA, Germain D, Friedman SL. Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.  Cancer Res.  2004;64;11  Link to Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.
  86. Letter Friedman SL. The answer: angiotensin II. The question: what do inflammation, oxidant stress and fibrogenesis have in common?  J. Hepatol.  2004;40;6  Link to The answer: angiotensin II. The question: what do inflammation, oxidant stress and fibrogenesis have in common?
  87. Journal ArticleReview Okuno M, Kojima S, Matsushima-Nishiwaki R, Tsurumi H, Muto Y, Friedman SL, Moriwaki H. Retinoids in cancer chemoprevention.  Curr Cancer Drug Targets  2004;4;3  Link to Retinoids in cancer chemoprevention.
  88. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, Hod E, Harpaz N, Goldberg S, Tal-Kremer S, Eng FJ, Arthur MJ, Martignetti JA, Friedman SL. Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.  Gastroenterology  2004;126;4  Link to Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
  89. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Kojima S, Okuno M, Matsushima-Nishiwaki R, Friedman SL, Moriwaki H. Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review).  Int. J. Oncol.  2004;24;4  Link to Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review).

    90. 2003

  90. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H. Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.  Carcinogenesis  2003;24;8  Link to Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.
  91. CommentJournal ArticleReview Narla G, Friedman SL, Martignetti JA. Krüppel cripples prostate cancer: KLF6 progress and prospects.  Am. J. Pathol.  2003;162;4  Link to Krüppel cripples prostate cancer: KLF6 progress and prospects.
  92. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Olaso E, Salado C, Egilegor E, Gutierrez V, Santisteban A, Sancho-Bru P, Friedman SL, Vidal-Vanaclocha F. Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis.  Hepatology  2003;37;3  Link to Proangiogenic role of tumor-activated hepatic stellate cells in experimental melanoma metastasis.
  93. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Albanis E, Safadi R, Friedman SL. Treatment of hepatic fibrosis: almost there.  Curr Gastroenterol Rep  2003;5;1  Link to Treatment of hepatic fibrosis: almost there.
  94. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Liver fibrosis -- from bench to bedside.  J. Hepatol.  2003;38 Suppl 1  Link to Liver fibrosis -- from bench to bedside.

    95. 2002

  95. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Mao TK, Kimura Y, Kenny TP, Branchi A, Gishi RG, Van de Water J, Kung HJ, Friedman SL, Gershwin ME. Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis.  Autoimmunity  2002;35;8  Link to Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis.
  96. In VitroJournal Article Obora A, Shiratori Y, Okuno M, Adachi S, Takano Y, Matsushima-Nishiwaki R, Yasuda I, Yamada Y, Akita K, Sano T, Shimada J, Kojima S, Okano Y, Friedman SL, Moriwaki H. Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells.  Hepatology  2002;36;5  Link to Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells.
  97. Journal ArticleReview Safadi R, Friedman SL. Hepatic fibrosis--role of hepatic stellate cell activation.  MedGenMed  2002;4;3  Link to Hepatic fibrosis--role of hepatic stellate cell activation.
  98. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice.  Hepatology  2002;35;4  Link to Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice.
  99. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Adachi S, Okuno M, Matsushima-Nishiwaki R, Takano Y, Kojima S, Friedman SL, Moriwaki H, Okano Y. Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma.  Hepatology  2002;35;2  Link to Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma.
  100. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species.  Hepatology  2002;35;1  Link to Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species.

    101. 2001

  101. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL. KLF6, a candidate tumor suppressor gene mutated in prostate cancer.  Science  2001;294;5551  Link to KLF6, a candidate tumor suppressor gene mutated in prostate cancer.
  102. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.  J. Clin. Invest.  2001;108;9  Link to DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.
  103. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Matsushima-Nishiwaki R, Okuno M, Adachi S, Sano T, Akita K, Moriwaki H, Friedman SL, Kojima S. Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma.  Cancer Res.  2001;61;20  Link to Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma.
  104. Journal ArticleReview Eng FJ, Friedman SL. Transcriptional regulation in hepatic stellate cells.  Semin. Liver Dis.  2001;21;3  Link to Transcriptional regulation in hepatic stellate cells.
  105. Journal Article Takehara T, Liu X, Fujimoto J, Friedman SL, Takahashi H. Expression and role of Bcl-xL in human hepatocellular carcinomas.  Hepatology  2001;34;1  Link to Expression and role of Bcl-xL in human hepatocellular carcinomas.
  106. Journal ArticleReview Albanis E, Friedman SL. Hepatic fibrosis. Pathogenesis and principles of therapy.  Clin Liver Dis  2001;5;2  Link to Hepatic fibrosis. Pathogenesis and principles of therapy.
  107. Journal Article Myers MJ, Friedman SL, Farrell DE, Dove-Pettit DA, Bucker MF, Kelly S, Madzo S, Campbell W, Wang RF, Paine D, Cerniglia CE. Validation of a polymerase chain reaction method for the detection of rendered bovine-derived materials in feedstuffs.  J. Food Prot.  2001;64;4  Link to Validation of a polymerase chain reaction method for the detection of rendered bovine-derived materials in feedstuffs.
  108. Historical ArticleJournal Article Berk PD, Min AD, Friedman SL. Hepatology at Mount Sinai: the present and the future.  Mt. Sinai J. Med.  2001;68;2  Link to Hepatology at Mount Sinai: the present and the future.
  109. Journal Article Shimizu M, Hara A, Okuno M, Matsuno H, Okada K, Ueshima S, Matsuo O, Niwa M, Akita K, Yamada Y, Yoshimi N, Uematsu T, Kojima S, Friedman SL, Moriwaki H, Mori H. Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis.  Hepatology  2001;33;3  Link to Mechanism of retarded liver regeneration in plasminogen activator-deficient mice: impaired activation of hepatocyte growth factor after Fas-mediated massive hepatic apoptosis.
  110. CommentEditorial Bonis PA, Friedman SL, Kaplan MM. Is liver fibrosis reversible?  N. Engl. J. Med.  2001;344;6  Link to Is liver fibrosis reversible?

    111. 2000

  111. Congresses Friedman SL, Maher JJ, Bissell DM. Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference.  Hepatology  2000;32;6  Link to Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference.
  112. Comparative StudyJournal Article Schenck FJ, Friedman SL. The effect of storage at 4 degrees C on the stability of ampicillin residues in raw milk.  Food Addit Contam  2000;17;8  Link to The effect of storage at 4 degrees C on the stability of ampicillin residues in raw milk.
  113. Journal ArticleReview Eng FJ, Friedman SL. Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex.  Am. J. Physiol. Gastrointest. Liver Physiol.  2000;279;1  Link to Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex.
  114. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Vogel S, Piantedosi R, Frank J, Lalazar A, Rockey DC, Friedman SL, Blaner WS. An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.  J. Lipid Res.  2000;41;6  Link to An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro.
  115. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman SL, Rustgi AK. The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact.  FEBS Lett.  2000;473;1  Link to The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact.
  116. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Kojima S, Hayashi S, Shimokado K, Suzuki Y, Shimada J, Crippa MP, Friedman SL. Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells.  Blood  2000;95;4  Link to Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells.

    117. 1999

  117. Journal Article Friedman SL. Evaluation of fibrosis and hepatitis C.  Am. J. Med.  1999;107;6B  Link to Evaluation of fibrosis and hepatitis C.
  118. CommentEditorialReview Friedman SL. The virtuosity of hepatic stellate cells.  Gastroenterology  1999;117;5  Link to The virtuosity of hepatic stellate cells.
  119. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Nieto N, Friedman SL, Greenwel P, Cederbaum AI. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells.  Hepatology  1999;30;4  Link to CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells.
  120. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Whalen R, Rockey DC, Friedman SL, Boyer TD. Activation of rat hepatic stellate cells leads to loss of glutathione S-transferases and their enzymatic activity against products of oxidative stress.  Hepatology  1999;30;4  Link to Activation of rat hepatic stellate cells leads to loss of glutathione S-transferases and their enzymatic activity against products of oxidative stress.
  121. Journal ArticleReview Li D, Friedman SL. Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy.  J. Gastroenterol. Hepatol.  1999;14;7  Link to Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy.
  122. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Okuno M, Sato T, Kitamoto T, Imai S, Kawada N, Suzuki Y, Yoshimura H, Moriwaki H, Onuki K, Masushige S, Muto Y, Friedman SL, Kato S, Kojima S. Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo.  J. Hepatol.  1999;30;6  Link to Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo.
  123. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Stellate cell activation in alcoholic fibrosis--an overview.  Alcohol. Clin. Exp. Res.  1999;23;5  Link to Stellate cell activation in alcoholic fibrosis--an overview.
  124. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Cytokines and fibrogenesis.  Semin. Liver Dis.  1999;19;2  Link to Cytokines and fibrogenesis.
  125. Journal Article Reichmister JP, Friedman SL. Long-term functional results after manipulation of the frozen shoulder.  Md Med J  1999;48;1  Link to Long-term functional results after manipulation of the frozen shoulder.

    126. 1998

  126. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Müller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, Li-Weber M, Friedman SL, Galle PR, Stremmel W, Oren M, Krammer PH. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs.  J. Exp. Med.  1998;188;11  Link to p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs.
  127. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Olaso E, Friedman SL. Molecular regulation of hepatic fibrogenesis.  J. Hepatol.  1998;29;5  Link to Molecular regulation of hepatic fibrogenesis.
  128. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, Jensen S, Friedman SL. Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.  Proc. Natl. Acad. Sci. U.S.A.  1998;95;16  Link to Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis.
  129. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Ankoma-Sey V, Matli M, Chang KB, Lalazar A, Donner DB, Wong L, Warren RS, Friedman SL. Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing.  Oncogene  1998;17;1  Link to Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing.
  130. Journal ArticleReview Friedman SL. Cellular networks in hepatic fibrosis.  Digestion  1998;59;4  Link to Cellular networks in hepatic fibrosis.

    131. 1997

  131. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Agani F, Kirsch DG, Friedman SL, Kastan MB, Semenza GL. p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.  Cancer Res.  1997;57;20  Link to p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
  132. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Lalazar A, Wong L, Yamasaki G, Friedman SL. Early genes induced in hepatic stellate cells during wound healing.  Gene  1997;195;2  Link to Early genes induced in hepatic stellate cells during wound healing.
  133. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Friedman SL, Shaulian E, Littlewood T, Resnitzky D, Oren M. Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells.  Oncogene  1997;15;1  Link to Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells.
  134. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Molecular mechanisms of hepatic fibrosis and principles of therapy.  J. Gastroenterol.  1997;32;3  Link to Molecular mechanisms of hepatic fibrosis and principles of therapy.
  135. CommentEditorialReview Friedman SL. Closing in on the signals of hepatic fibrosis.  Gastroenterology  1997;112;4  Link to Closing in on the signals of hepatic fibrosis.
  136. Journal ArticleReview Friedman SL. Scarring in alcoholic liver disease: new insights and emerging therapies.  Alcohol Health Res World  1997;21;4  Link to Scarring in alcoholic liver disease: new insights and emerging therapies.

    137. 1996

  137. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Hepatic stellate cells.  Prog Liver Dis  1996;14  Link to Hepatic stellate cells.

    138. 1995

  138. Journal Article Friedman SL. Parenchymal Fe and collagen gene expression: an iron-clad association?  Hepatology  1995;21;4  Link to Parenchymal Fe and collagen gene expression: an iron-clad association?
  139. Journal ArticleReview Housset CN, Rockey DC, Friedman SL, Bissell DM. Hepatic lipocytes: a major target for endothelin-1.  J. Hepatol.  1995;22;2 Suppl  Link to Hepatic lipocytes: a major target for endothelin-1.

    140. 1994

  140. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Wong L, Yamasaki G, Johnson RJ, Friedman SL. Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.  J. Clin. Invest.  1994;94;4  Link to Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

    141. 1993

  141. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Rockey DC, Housset CN, Friedman SL. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.  J. Clin. Invest.  1993;92;4  Link to Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.
  142. Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.  N. Engl. J. Med.  1993;328;25  Link to Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.
  143. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Friedman SL, Wei S, Blaner WS. Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF.  Am. J. Physiol.  1993;264;5 Pt 1  Link to Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF.
  144. Journal ArticleReview Maher JJ, Friedman SL. Parenchymal and nonparenchymal cell interactions in the liver.  Semin. Liver Dis.  1993;13;1  Link to Parenchymal and nonparenchymal cell interactions in the liver.

    145. 1992

  145. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Rockey DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL. Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma.  Hepatology  1992;16;3  Link to Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma.
  146. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJ. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.  J. Clin. Invest.  1992;90;1  Link to Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.
  147. Journal ArticleReview Herndier BG, Friedman SL. Neoplasms of the gastrointestinal tract and hepatobiliary system in acquired immunodeficiency syndrome.  Semin. Liver Dis.  1992;12;2  Link to Neoplasms of the gastrointestinal tract and hepatobiliary system in acquired immunodeficiency syndrome.
  148. Editorial Friedman SL. "Cuts both ways": collagenases, lipocyte activation and polyunsaturated lecithin.  Hepatology  1992;15;3  Link to "Cuts both ways": collagenases, lipocyte activation and polyunsaturated lecithin.
  149. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture.  Hepatology  1992;15;2  Link to Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture.

    150. 1991

  150. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Friedman G, Liu LM, Friedman SL, Boyles JK. Apolipoprotein E is secreted by cultured lipocytes of the rat liver.  J. Lipid Res.  1991;32;1  Link to Apolipoprotein E is secreted by cultured lipocytes of the rat liver.

    151. 1990

  151. Journal ArticleReview Friedman SL. Acetaldehyde and alcoholic fibrogenesis: fuel to the fire, but not the spark.  Hepatology  1990;12;3 Pt 1  Link to Acetaldehyde and alcoholic fibrogenesis: fuel to the fire, but not the spark.
  152. Journal ArticleReview Friedman SL. Kaposi's sarcoma and lymphoma of the gut in AIDS.  Baillieres Clin. Gastroenterol.  1990;4;2  Link to Kaposi's sarcoma and lymphoma of the gut in AIDS.
  153. Journal ArticleReview Friedman SL, Bissell DM. Hepatic fibrosis: new insights into pathogenesis.  Hosp. Pract. (Off. Ed.)  1990;25;5  Link to Hepatic fibrosis: new insights into pathogenesis.
  154. Journal ArticleReview Bissell DM, Friedman SL, Maher JJ, Roll FJ. Connective tissue biology and hepatic fibrosis: report of a conference.  Hepatology  1990;11;3  Link to Connective tissue biology and hepatic fibrosis: report of a conference.
  155. Journal ArticleReview Friedman SL. Cellular sources of collagen and regulation of collagen production in liver.  Semin. Liver Dis.  1990;10;1  Link to Cellular sources of collagen and regulation of collagen production in liver.

    156. 1989

  156. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Friedman SL, Arthur MJ. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.  J. Clin. Invest.  1989;84;6  Link to Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.
  157. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Arthur MJ, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.  J. Clin. Invest.  1989;84;4  Link to Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.

    158. 1988

  158. Journal ArticleReview Friedman SL. Gastrointestinal and hepatobiliary neoplasms in AIDS.  Gastroenterol. Clin. North Am.  1988;17;3  Link to Gastrointestinal and hepatobiliary neoplasms in AIDS.
  159. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Arenson DM, Friedman SL, Bissell DM. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan.  Gastroenterology  1988;95;2  Link to Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan.
  160. Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S. Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer.  J. Clin. Invest.  1988;82;2  Link to Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer.
  161. Journal ArticleResearch Support, U.S. Gov't, P.H.S. Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture.  Gastroenterology  1988;94;4  Link to Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture.
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