Brechot, Christian

List of all publications

Publishing since 1979 (Dinosaur)

2009

Battaglia S, Benzoubir N, Ghigna MR, Guettier C, Bréchot C, Bourgeade MF. [In Process Citation] Ann Pathol 2009;29 Spec No 1
Battaglia S, Benzoubir N, Nobilet S, Charneau P, Samuel D, Zignego AL, Atfi A, Bréchot C, Bourgeade MF. Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. PLoS ONE 2009;4;2

2008

Hervé J, Cunha AS, Liu B, Valogne Y, Longuet M, Boisgard R, Brégerie O, Roux J, Guettier C, Calès P, Tavitian B, Samuel D, Clerc J, Bréchot C, Faivre J. Internal radiotherapy of liver cancer with rat hepatocarcinoma-intestine-pancreas gene as a liver tumor-specific promoter. Hum. Gene Ther. 2008;19;9
Herve J, Sa Cunha A, Liu B, Valogne Y, Longuet M, Boisgard R, Bregerie O, Roux J, Guettier C, Cales P, Tavitian B, Samuel D, Clerc J, Brechot C, Faivre J. Internal radiotherapy of liver cancer with rat Hepatocarcinoma-Intestine-Pancreas gene as a liver tumor-specific promoter. Hum. Gene Ther. 2008
Faria LC, Gigou M, Roque-Afonso AM, Sebagh M, Roche B, Fallot G, Ferrari TC, Guettier C, Dussaix E, Castaing D, Brechot C, Samuel D. Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. Gastroenterology 2008;134;7
Yan XB, Mei L, Feng X, Wan MR, Chen Z, Pavio N, Brechot C. Hepatitis C virus core proteins derived from different quasispecies of genotype 1b inhibit the growth of Chang liver cells. World J. Gastroenterol. 2008;14;18
Arrais TC, Van Dooren S, Vandamme AM, Brechot C, Rimlinger F, Silva AE, Perez RM, Ferraz ML, Thiers V. Change in hepatitis C virus genotype in hemodialysis patients after end-of-treatment response to interferon monotherapy--relapse or re-infection? J. Med. Virol. 2008;80;1

2007

Sobesky R, Feray C, Rimlinger F, Derian N, Dos Santos A, Roque-Afonso AM, Samuel D, Bréchot C, Thiers V. Distinct hepatitis C virus core and F protein quasispecies in tumoral and nontumoral hepatocytes isolated via microdissection. Hepatology 2007;46;6
Liu B, Hervé J, Bioulac-Sage P, Valogne Y, Roux J, Yilmaz F, Boisgard R, Guettier C, Calès P, Tavitian B, Samuel D, Clerc J, Bréchot C, Faivre J. Sodium iodide symporter is expressed at the preneoplastic stages of liver carcinogenesis and in human cholangiocarcinoma. Gastroenterology 2007;132;4
Yan XB, Battaglia S, Boucreux D, Chen Z, Brechot C, Pavio N. Mapping of the interacting domains of hepatitis C virus core protein and the double-stranded RNA-activated protein kinase PKR. Virus Res. 2007;125;1
Robert A, Margall-Ducos G, Guidotti JE, Brégerie O, Celati C, Bréchot C, Desdouets C. The intraflagellar transport component IFT88/polaris is a centrosomal protein regulating G1-S transition in non-ciliated cells. J. Cell. Sci. 2007;120;Pt 4
Chami M, Benali NL, Bréchot C, Paterlini-Bréchot P. [Impact of calcium signaling in liver carcinogenesis] Med Sci (Paris) 2007;23;2

2006

Lieu HT, Simon MT, Nguyen-Khoa T, Kebede M, Cortes A, Tebar L, Smith AJ, Bayne R, Hunt SP, Bréchot C, Christa L. Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Hepatology 2006;44;6
Hervieu V, Christa L, Gouysse G, Bouvier R, Chayvialle JA, Bréchot C, Scoazec JY. HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors. Hum. Pathol. 2006;37;8
Toyoda H, Kumada T, Bregerie O, Brechot C, Desdouets C. Conserved balance of hepatocyte nuclear DNA content in mononuclear and binuclear hepatocyte populations during the course of chronic viral hepatitis. World J. Gastroenterol. 2006;12;28
Kremsdorf D, Soussan P, Paterlini-Brechot P, Brechot C. Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis. Oncogene 2006;25;27
Chignard N, Shang S, Wang H, Marrero J, Bréchot C, Hanash S, Beretta L. Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera. Gastroenterology 2006;130;7
Mancini-Bourgine M, Fontaine H, Bréchot C, Pol S, Michel ML. Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers. Vaccine 2006;24;21
Morosan S, Hez-Deroubaix S, Lunel F, Renia L, Giannini C, Van Rooijen N, Battaglia S, Blanc C, Eling W, Sauerwein R, Hannoun L, Belghiti J, Brechot C, Kremsdorf D, Druilhe P. Liver-stage development of Plasmodium falciparum, in a humanized mouse model. J. Infect. Dis. 2006;193;7

2005

Peltekian C, Gordien E, Garreau F, Meas-Yedid V, Soussan P, Willams V, Chaix ML, Olivo-Marin JC, Bréchot C, Kremsdorf D. Human MxA protein participates to the interferon-related inhibition of hepatitis B virus replication in female transgenic mice. J. Hepatol. 2005;43;6
Haeffner-Cavaillon N, Graillot-Gak C, Bréchot C. Automated grading of research performance clearly fails to measure up. Nature 2005;438;7068
Pavio N, Battaglia S, Boucreux D, Arnulf B, Sobesky R, Hermine O, Brechot C. Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway. Oncogene 2005;24;40
Lieu HT, Batteux F, Simon MT, Cortes A, Nicco C, Zavala F, Pauloin A, Tralhao JG, Soubrane O, Weill B, Bréchot C, Christa L. HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice. Hepatology 2005;42;3
Murakami Y, Saigo K, Takashima H, Minami M, Okanoue T, Bréchot C, Paterlini-Bréchot P. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 2005;54;8
Toyoda H, Bregerie O, Vallet A, Nalpas B, Pivert G, Brechot C, Desdouets C. Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis. Gut 2005;54;2
André P, Perlemuter G, Budkowska A, Bréchot C, Lotteau V. Hepatitis C virus particles and lipoprotein metabolism. Semin. Liver Dis. 2005;25;1

2004

Faivre J, Clerc J, Gérolami R, Hervé J, Longuet M, Liu B, Roux J, Moal F, Perricaudet M, Bréchot C. Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats. Cancer Res. 2004;64;21
Bréchot C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms. Gastroenterology 2004;127;5 Suppl 1
Mancini-Bourgine M, Fontaine H, Scott-Algara D, Pol S, Bréchot C, Michel ML. Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers. Hepatology 2004;40;4
Bréchot C. [Health translational research, a new paradigm] Med Sci (Paris) 2004;20;10
Girard S, Vossman E, Misek DE, Podevin P, Hanash S, Bréchot C, Beretta L. Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses. Hepatology 2004;40;3
Vona G, Tuveri R, Delpuech O, Vallet A, Canioni D, Ballardini G, Baptiste Trabut J, Le Bail B, Nalpas B, Carnot F, Pol S, Brechot C, Thiers V. Intrahepatic hepatitis C virus RNA quantification in microdissected hepatocytes. J. Hepatol. 2004;40;4
Vona G, Estepa L, Béroud C, Damotte D, Capron F, Nalpas B, Mineur A, Franco D, Lacour B, Pol S, Bréchot C, Paterlini-Bréchot P. Impact of cytomorphological detection of circulating tumor cells in patients with liver cancer. Hepatology 2004;39;3
Lebray P, Zylberberg H, Hue S, Poulet B, Carnot F, Martin S, Chretien Y, Pol S, Caillat-Zuckman S, Bréchot C, Nalpas B. Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C. J. Viral Hepat. 2004;11;2
Gerolami R, Uch R, Faivre J, Garcia S, Hardwigsen J, Cardoso J, Mathieu S, Bagnis C, Brechot C, Mannoni P. Herpes simplex virus thymidine kinase-mediated suicide gene therapy for hepatocellular carcinoma using HIV-1-derived lentiviral vectors. J. Hepatol. 2004;40;2
Pol S, Carnot F, Nalpas B, Lagneau JL, Fontaine H, Serpaggi J, Serfaty L, Bedossa P, Bréchot C. Reversibility of hepatitis C virus-related cirrhosis. Hum. Pathol. 2004;35;1

2003

Perlemuter G, Lettéron P, Carnot F, Zavala F, Pessayre D, Nalpas B, Bréchot C. Alcohol and hepatitis C virus core protein additively increase lipid peroxidation and synergistically trigger hepatic cytokine expression in a transgenic mouse model. J. Hepatol. 2003;39;6
Gérolami R, Uch R, Bréchot C, Mannoni P, Bagnis C. Gene therapy of hepatocarcinoma: a long way from the concept to the therapeutical impact. Cancer Gene Ther. 2003;10;9
Iavarone M, Trabut JB, Delpuech O, Carnot F, Colombo M, Kremsdorf D, Bréchot C, Thiers V. Characterisation of hepatitis B virus X protein mutants in tumour and non-tumour liver cells using laser capture microdissection. J. Hepatol. 2003;39;2
Paterlini-Bréchot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Bréchot C. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene 2003;22;25
Brechot C. New research actions and organizations in France. Hepatology 2003;37;5
Soussan P, Tuveri R, Nalpas B, Garreau F, Zavala F, Masson A, Pol S, Brechot C, Kremsdorf D. The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis. J. Hepatol. 2003;38;3
Lebray P, Vallet-Pichard A, Michel ML, Fontaine H, Sobesky R, Bréchot C, Pol S. Immunomodulatory drugs and therapeutic vaccine in chronic hepatitis B infection. J. Hepatol. 2003;39 Suppl 1

2002

Wang XW, Hussain SP, Huo TI, Wu CG, Forgues M, Hofseth LJ, Brechot C, Harris CC. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology 2002;181-182
Lafarge-Frayssinet C, Martin C, Van Binh PN, Achard-Ellouk S, Duc HT, Frayssinet C, Cardoso G, Desauty G, Warnet JM, Bréchot C, Sarasin A. Adenovirus-mediated anti insulin-like growth factor I gene transfer for the treatment of hepatocellular carcinoma. Anticancer Res. 2002;22;6C
Sa Cunha A, Bonte E, Dubois S, Chrétien Y, Eraiser T, Degott C, Bréchot C, Tran PL. Inhibition of rat hepatocellular carcinoma tumor growth after multiple infusions of recombinant Ad.AFPtk followed by ganciclovir treatment. J. Hepatol. 2002;37;2
Hermine O, Lefrère F, Bronowicki JP, Mariette X, Jondeau K, Eclache-Saudreau V, Delmas B, Valensi F, Cacoub P, Brechot C, Varet B, Troussard X. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N. Engl. J. Med. 2002;347;2
André P, Komurian-Pradel F, Deforges S, Perret M, Berland JL, Sodoyer M, Pol S, Bréchot C, Paranhos-Baccalà G, Lotteau V. Characterization of low- and very-low-density hepatitis C virus RNA-containing particles. J. Virol. 2002;76;14
Giannini C, Caini P, Giannelli F, Fontana F, Kremsdorf D, Bréchot C, Zignego AL. Hepatitis C virus core protein expression in human B-cell lines does not significantly modify main proliferative and apoptosis pathways. J. Gen. Virol. 2002;83;Pt 7
Bichr S, Rende-Fournier R, Vona G, Yamamoto AM, Depla E, Maertens G, Bréchot C. Detection of neutralizing antibodies to hepatitis C virus using a biliary cell infection model. J. Gen. Virol. 2002;83;Pt 7
Tralhao JG, Roudier J, Morosan S, Giannini C, Tu H, Goulenok C, Carnot F, Zavala F, Joulin V, Kremsdorf D, Bréchot C. Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis. Proc. Natl. Acad. Sci. U.S.A. 2002;99;10
Delpuech O, Trabut JB, Carnot F, Feuillard J, Brechot C, Kremsdorf D. Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinoma. Oncogene 2002;21;18
Girard S, Shalhoub P, Lescure P, Sabile A, Misek DE, Hanash S, Bréchot C, Beretta L. An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis. Virology 2002;295;2
Faivre J, Frank-Vaillant M, Poulhe R, Mouly H, Jessus C, Bréchot C, Sobczak-Thépot J. Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2. Oncogene 2002;21;10

2001

Desenclos JC, Bourdiol-Razès M, Rolin B, Garandeau P, Ducos J, Bréchot C, Thiers V. Hepatitis C in a ward for cystic fibrosis and diabetic patients: possible transmission by spring-loaded finger-stick devices for self-monitoring of capillary blood glucose. Infect Control Hosp Epidemiol 2001;22;11
Tu H, Bonura C, Giannini C, Mouly H, Soussan P, Kew M, Paterlini-Bréchot P, Bréchot C, Kremsdorf D. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res. 2001;61;21
Op De Beeck A, Sobczak-Thepot J, Sirma H, Bourgain F, Brechot C, Caillet-Fauquet P. NS1- and minute virus of mice-induced cell cycle arrest: involvement of p53 and p21(cip1). J. Virol. 2001;75;22
Faivre J, Frank-Vaillant M, Poulhe R, Mouly H, Bréchot C, Sobczak-Thépot J, Jessus C. Membrane-anchored cyclin A2 triggers Cdc2 activation in Xenopus oocyte. FEBS Lett. 2001;506;3
Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Bréchot C, Paterlini-Bréchot P. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging. Oncogene 2001;20;43
Delhem N, Sabile A, Gajardo R, Podevin P, Abadie A, Blaton MA, Kremsdorf D, Beretta L, Brechot C. Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein. Oncogene 2001;20;41
Fontaine H, Nalpas B, Poulet B, Carnot F, Zylberberg H, Brechot C, Pol S. Hepatitis activity index is a key factor in determining the natural history of chronic hepatitis C. Hum. Pathol. 2001;32;9
Nalpas B, Martin S, Fontaine H, Fabbro-Peray P, Bréchot C, Pol S. Impact of medical recommendations on alcohol consumption in HCV positive patients. J. Hepatol. 2001;35;2
Bréchot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Bréchot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"? Hepatology 2001;34;1
Huo TI, Wang XW, Forgues M, Wu CG, Spillare EA, Giannini C, Brechot C, Harris CC. Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis. Oncogene 2001;20;28
Podevin P, Sabile A, Gajardo R, Delhem N, Abadie A, Lozach PY, Beretta L, Bréchot C. Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner. Hepatology 2001;33;6
Michel ML, Pol S, Brechot C, Tiollais P. Immunotherapy of chronic hepatitis B by anti HBV vaccine: from present to future. Vaccine 2001;19;17-19
Gerolami R, Uch R, Cardoso J, Bagnis C, Mannoni P, Bréchot C. [Gene therapy for hepatocellular carcinoma. From the idea to clinical trials] Gastroenterol. Clin. Biol. 2001;25;3
Gordien E, Rosmorduc O, Peltekian C, Garreau F, Bréchot C, Kremsdorf D. Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein. J. Virol. 2001;75;6
Soussan P, Pol S, Garreau F, Bréchot C, Kremsdorf D. Vaccination of chronic hepatitis B virus carriers with preS2/S envelope protein is not associated with the emergence of envelope escape mutants. J. Gen. Virol. 2001;82;Pt 2

2000

Zylberberg H, Benhamou Y, Lagneaux JL, Landau A, Chaix ML, Fontaine H, Bochet M, Poynard T, Katlama C, Pialoux G, Bréchot C, Pol S. Safety and efficacy of interferon-ribavirin combination therapy in HCV-HIV coinfected subjects: an early report. Gut 2000;47;5
Fontaine H, Nalpas B, Carnot F, Bréchot C, Pol S. Effect of pregnancy on chronic hepatitis C: a case-control study. Lancet 2000;356;9238
Zylberberg H, Nalpas B, Pol S, Bréchot C, Viard JP. Is there a relationship between hepatitis C virus infection and antiretroviral-associated lipoatrophy? AIDS 2000;14;13
Zylberberg H, Fontaine H, Corréas JM, Carnot F, Bréchot C, Pol S. Dilated bile duct in patients receiving narcotic substitution: an early report. J. Clin. Gastroenterol. 2000;31;2
Gerolami R, Uch R, Jordier F, Chapel S, Bagnis C, Bréchot C, Mannoni P. Gene transfer to hepatocellular carcinoma: transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors. Cancer Gene Ther. 2000;7;9
Tuveri R, Jaffredo F, Lunel F, Nalpa B, Pol S, Feray C, Marcellin P, Thibault V, Delagneau JF, Opolon P, Scarpa B, Bréchot C, Thiers V. Impact of TT virus infection in acute and chronic, viral- and non viral-related liver diseases. J. Hepatol. 2000;33;1
Fontaine H, Chaix ML, Lagneau JL, Bréchot C, Pol S. Recovery from chronic hepatitis C in long-term responders to ribavirin plus interferon alfa. Lancet 2000;356;9223
Chami M, Gozuacik D, Saigo K, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Bréchot C, Paterlini-Bréchot P. Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. Oncogene 2000;19;25
Pol S, Nalpas B, Bourlière M, Couzigou P, Tran A, Abergel A, Zarski JP, Berthelot P, Bréchot C. Combination of ribavirin and interferon-alfa surpasses high doses of interferon-alfa alone in patients with genotype-1b-related chronic hepatitis C. Hepatology 2000;31;6
Fontaine H, Thiers V, Chrétien Y, Zylberberg H, Poupon RE, Bréchot C, Legendre C, Kreis H, Pol S. HBV genotypic resistance to lamivudine in kidney recipients and hemodialyzed patients. Transplantation 2000;69;10
Zylberberg H, Chaix ML, Bréchot C. Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha. Ann. Intern. Med. 2000;132;10
Nalpas B, Zylberberg H, Dubois F, Presles MA, Gillant JC, Lienard M, Delemotte B, Bréchot C. [Prevalence of infection by hepatitis viruses in a rural area. Analysis according to risk factors and alcohol consumption] Gastroenterol. Clin. Biol. 2000;24;5
Bilbao R, Gérolami R, Bralet MP, Qian C, Tran PL, Tennant B, Prieto J, Bréchot C. Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ ganciclovir therapy of hepatocellular carcinoma: the woodchuck animal model. Cancer Gene Ther. 2000;7;5
Perlemuter G, Sabile A, Bréchot C. [Interactions between hepatitis C virus and hepatic lipid metabolism] Gastroenterol. Clin. Biol. 2000;24;5
Pol S, Michel ML, Bréchot C. Immune therapy of hepatitis B virus (HBV) chronic infection. European experience. Acta Gastroenterol. Belg. 2000;63;2
Pol S, Samuel D, Cadranel J, Legendre C, Bismuth H, Bréchot C, Kreis H. Hepatitis and solid organ transplantation. Transplant. Proc. 2000;32;2
Gerolami R, Cardoso J, Lewin M, Bralet MP, Sa Cunha A, Clément O, Bréchot C, Tran PL. Evaluation of HSV-tk gene therapy in a rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes. Cancer Res. 2000;60;4
Hegenbarth S, Gerolami R, Protzer U, Tran PL, Brechot C, Gerken G, Knolle PA. Liver sinusoidal endothelial cells are not permissive for adenovirus type 5. Hum. Gene Ther. 2000;11;3
Pol S, Michel ML, Bréchot C. Immune therapy of hepatitis B virus chronic infection. Hepatology 2000;31;2
Kirk GD, Camus-Randon AM, Mendy M, Goedert JJ, Merle P, Trépo C, Bréchot C, Hainaut P, Montesano R. Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia. J. Natl. Cancer Inst. 2000;92;2
Soussan P, Garreau F, Zylberberg H, Ferray C, Brechot C, Kremsdorf D. In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA. J. Clin. Invest. 2000;105;1
Vona G, Sabile A, Louha M, Sitruk V, Romana S, Schütze K, Capron F, Franco D, Pazzagli M, Vekemans M, Lacour B, Bréchot C, Paterlini-Bréchot P. Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells. Am. J. Pathol. 2000;156;1

1999

Bluteau O, Legoix P, Bayer J, Bioulac-Sage P, Fléjou JF, Capron F, Monges G, Brechot C, Thomas G, Laurent-Puig P, Zucman-Rossi J. [Semi-automated quantitative method for detecting the loss of heterozygosity at the long arm of chromosome 4 in hepatocellular carcinoma] Gastroenterol. Clin. Biol. 1999;23;11
Christa L, Simon MT, Brezault-Bonnet C, Bonte E, Carnot F, Zylberberg H, Franco D, Capron F, Roskams T, Bréchot C. Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Am. J. Pathol. 1999;155;5
Sabile A, Perlemuter G, Bono F, Kohara K, Demaugre F, Kohara M, Matsuura Y, Miyamura T, Bréchot C, Barba G. Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates. Hepatology 1999;30;4
Poynard T, Daurat V, Chevret S, Moussalli J, Degos F, Bailly F, Borotto E, Buffet C, Bartolomei-Portal I, Richardet JP, Riachi G, Calmus Y, Bréchot C, Vidaud M, Olivi M, Bedossa P, Riffaud PC, Chastang C. A short induction regimen of interferon-alpha is not effective for treatment of relapse in chronic hepatitis C: a randomized trial. For the multicentre GER-CYT-01 group. J. Viral Hepat. 1999;6;5
Bonura C, Paterlini-Brechot P, Brechot C. Structure and expression of Tg737, a putative tumor suppressor gene, in human hepatocellular carcinomas. Hepatology 1999;30;3
Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Bréchot C. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999;18;34
McIntyre M, Desdouets C, Sénamaud-Beaufort C, Laurent-Winter C, Lamas E, Bréchot C. Differential expression of the cyclin-dependent kinase inhibitor P27 in primary hepatocytes in early-mid G1 and G1/S transitions. Oncogene 1999;18;32
Zignego AL, Bréchot C. Extrahepatic manifestations of HCV infection: facts and controversies. J. Hepatol. 1999;31;2
Sabile A, Louha M, Bonte E, Poussin K, Vona G, Mejean A, Chretien Y, Bougas L, Lacour B, Capron F, Roseto A, Bréchot C, Paterlini-Bréchot P. Efficiency of Ber-EP4 antibody for isolating circulating epithelial tumor cells before RT-PCR detection. Am. J. Clin. Pathol. 1999;112;2
Pol S, Couzigou P, Bourlière M, Abergel A, Combis JM, Larrey D, Tran A, Moussalli J, Poupon R, Berthelot P, Bréchot C. A randomized trial of ribavirin and interferon-alpha vs. interferon-alpha alone in patients with chronic hepatitis C who were non-responders to a previous treatment. Multicenter Study Group under the coordination of the Necker Hospital, Paris, France. J. Hepatol. 1999;31;1
Zylberberg H, Pol S, Thiers V, Chaix ML, Lagorce D, Bréchot C, Nalpas B, Berthelot P. Significance of repeatedly normal aminotransferase activities in HCV-infected patients. J. Clin. Gastroenterol. 1999;29;1
Zylberberg H, Thiers V, Lagorce D, Squadrito G, Leone F, Berthelot P, Bréchot C, Pol S. Epidemiological and virological analysis of couples infected with hepatitis C virus. Gut 1999;45;1
Couillin I, Pol S, Mancini M, Driss F, Bréchot C, Tiollais P, Michel ML. Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens. J. Infect. Dis. 1999;180;1
Brechot C. The direct interplay between HCV NS5A protein and interferon transduction signal: from clinical to basic science. J. Hepatol. 1999;30;6
Loriot MA, Bronowicki JP, Lagorce D, Lakehal F, Persico T, Barba G, Mergey M, Vons C, Franco D, Belghiti J, Giacca M, Housset C, Bréchot C. Permissiveness of human biliary epithelial cells to infection by hepatitis C virus. Hepatology 1999;29;5
Rosmorduc O, Sirma H, Soussan P, Gordien E, Lebon P, Horisberger M, Bréchot C, Kremsdorf D. Inhibition of interferon-inducible MxA protein expression by hepatitis B virus capsid protein. J. Gen. Virol. 1999;80 ( Pt 5)
Lasserre C, Colnot C, Bréchot C, Poirier F. HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo. Am. J. Pathol. 1999;154;5
Zylberberg H, Fontaine H, Thépot V, Nalpas B, Bréchot C, Pol S. Triggering of acute alcoholic hepatitis by alpha-interferon therapy. J. Hepatol. 1999;30;4
Louha M, Nicolet J, Zylberberg H, Sabile A, Vons C, Vona G, Poussin K, Tournebize M, Capron F, Pol S, Franco D, Lacour B, Bréchot C, Paterlini-Bréchot P. Liver resection and needle liver biopsy cause hematogenous dissemination of liver cells. Hepatology 1999;29;3
Rosmorduc O, Paterlini P, Poupon R, Brechot C. [Hepatitis virus and hepatocellular carcinoma] Gastroenterol. Clin. Biol. 1999;23;3
Poussin K, Dienes H, Sirma H, Urban S, Beaugrand M, Franco D, Schirmacher P, Bréchot C, Paterlini Bréchot P. Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas. Int. J. Cancer 1999;80;4
Zylberberg H, Rimaniol AC, Pol S, Masson A, De Groote D, Berthelot P, Bach JF, Bréchot C, Zavala F. Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity. J. Hepatol. 1999;30;2
Pol S, Zylberberg H, Fontaine H, Bréchot C. Treatment of chronic hepatitis C in special groups. J. Hepatol. 1999;31 Suppl 1
Pol S, Bréchot C. Treatment of chronic hepatitis C. Acta Gastroenterol. Belg. 1999;62;1

1998

Leone F, Zylberberg H, Squadrito G, Le Guen B, Berthelot P, Pol S, Brechot C. Hepatitis C virus (HCV) hypervariable region 1 complexity does not correlate with severity of liver disease, HCV type, viral load or duration of infection. J. Hepatol. 1998;29;5
Zylberberg H, Pialoux G, Carnot F, Landau A, Bréchot C, Pol S. Rapidly evolving hepatitis C virus-related cirrhosis in a human immunodeficiency virus-infected patient receiving triple antiretroviral therapy. Clin. Infect. Dis. 1998;27;5
Lunel F, Frangeul L, Chuteau C, Fretz C, Thiers V, Azar N, Bidet JM, Huraux JM, Bréchot C, Valla D, Opolon P. Transfusion-associated or nosocomial hepatitis G virus infection in patients undergoing surgery. Transfusion 1998;38;11-12
Zylberberg H, Landau A, Carnot F, Driss F, Chaix ML, Bréchot C, Kreis H, Legendre C, Pol S. Impact of co-infection by hepatitis B virus and hepatitis C virus in renal transplantation. Transplant. Proc. 1998;30;6
Venegas M, Thiers V, Velasco M, Muñoz G, Brahm J, Alegría S, Brechot C, Lamas E. [Hepatitis G infection in Chilean patients with hepatitis C virus: a preliminary report] Rev Med Chil 1998;126;9
Muñoz G, Velasco M, Thiers V, Hurtado C, Brahm J, Larrondo-Lillo M, Guglielmetti A, Smok G, Brechot C, Lamas E. [Prevalence and genotypes of hepatitis C virus in blood donors and in patients with chronic liver disease and hepatocarcinoma in a Chilean population] Rev Med Chil 1998;126;9
Bréchot C, Jaffredo F, Lagorce D, Gerken G, Meyer zum Büschenfelde K, Papakonstontinou A, Hadziyannis S, Romeo R, Colombo M, Rodes J, Bruix J, Williams R, Naoumov N. Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted action. J. Hepatol. 1998;29;2
Brechot C. Molecular mechanisms of hepatitis B and C viruses related to liver carcinogenesis. Hepatogastroenterology 1998;45 Suppl 3
Pol S, Fontaine H, Carnot F, Zylberberg H, Berthelot P, Bréchot C, Nalpas B. Predictive factors for development of cirrhosis in parenterally acquired chronic hepatitis C: a comparison between immunocompetent and immunocompromised patients. J. Hepatol. 1998;29;1
Bronowicki JP, Loriot MA, Thiers V, Grignon Y, Zignego AL, Bréchot C. Hepatitis C virus persistence in human hematopoietic cells injected into SCID mice. Hepatology 1998;28;1
Gérolami R, Cardoso J, Bralet MP, Cuenod CA, Clément O, Tran PL, Bréchot C. Enhanced in vivo adenovirus-mediated gene transfer to rat hepatocarcinomas by selective administration into the hepatic artery. Gene Ther. 1998;5;7
Pol S, Lamorthe B, Thi NT, Thiers V, Carnot F, Zylberberg H, Berthelot P, Bréchot C, Nalpas B. Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users. J. Hepatol. 1998;28;6
Nalpas B, Pol S, Thépot V, Zylberberg H, Berthelot P, Bréchot C. ESBRA 1997 Award lecture: relationship between excessive alcohol drinking and viral infections. Alcohol Alcohol. 1998;33;3
Zylberberg H, Chaix ML, Rabian C, Rouzioux C, Aulong B, Bréchot C, Viard JP, Pol S. Tritherapy for human immunodeficiency virus infection does not modify replication of hepatitis C virus in coinfected subjects. Clin. Infect. Dis. 1998;26;5
Sirma H, Weil R, Rosmorduc O, Urban S, Israël A, Kremsdorf D, Bréchot C. Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome. Oncogene 1998;16;16
Pol S, Couillin I, Michel ML, Driss F, Nalpas B, Carnot F, Berthelot P, Bréchot C. Immunotherapy of chronic hepatitis B by anti HBV vaccine. Acta Gastroenterol. Belg. 1998;61;2
Zylberberg H, Nalpas B, Brechot C, Berthelot P. Significance of repeatedly normal aminotransferase activities in hepatitis C virus-infected patients. Hepatology 1998;27;4
Semprini AE, Persico T, Thiers V, Oneta M, Tuveri R, Serafini P, Boschini A, Giuntelli S, Pardi G, Brechot C. Absence of hepatitis C virus and detection of hepatitis G virus/GB virus C RNA sequences in the semen of infected men. J. Infect. Dis. 1998;177;4
Berasain C, Patil D, Perara E, Huang SM, Mouly H, Bréchot C. Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon hepatitis B virus genome insertion. Oncogene 1998;16;10
Thiers V, Pol S, Persico T, Carnot F, Zylberberg H, Berthelot P, Bréchot C, Nalpas B. Hepatitis G virus infection in hepatitis C virus-positive patients co-infected or not with hepatitis B virus and/or human immunodeficiency virus. J. Viral Hepat. 1998;5;2

1997

Louha M, Poussin K, Ganne N, Zylberberg H, Nalpas B, Nicolet J, Capron F, Soubrane O, Vons C, Pol S, Beaugrand M, Berthelot P, Franco D, Trinchet JC, Bréchot C, Paterlini P. Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer. Hepatology 1997;26;4
Squadrito G, Leone F, Sartori M, Nalpas B, Berthelot P, Raimondo G, Pol S, Bréchot C. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa. Gastroenterology 1997;113;2
Le Guen B, Squadrito G, Nalpas B, Berthelot P, Pol S, Brechot C. Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C. Hepatology 1997;25;5
Thiers V, Jaffredo F, Tuveri R, Chodan N, Bréchot C. Development of a simple restriction fragment length polymorphism (RFLP) based assay for HCV genotyping and comparative analysis with genotyping and serotyping tests. J. Virol. Methods 1997;65;1
Brechot C. Hepatitis C virus 1b, cirrhosis, and hepatocellular carcinoma. Hepatology 1997;25;3
Barba G, Harper F, Harada T, Kohara M, Goulinet S, Matsuura Y, Eder G, Schaff Z, Chapman MJ, Miyamura T, Bréchot C. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc. Natl. Acad. Sci. U.S.A. 1997;94;4
Brind A, Jiang J, Samuel D, Gigou M, Feray C, Bréchot C, Kremsdorf D. Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection. J. Hepatol. 1997;26;2
Tuveri R, Rothschild C, Pol S, Reijasse D, Persico T, Gazengel C, Bréchot C, Thiers V. Hepatitis C virus genotypes in French haemophiliacs: kinetics and reappraisal of mixed infections. J. Med. Virol. 1997;51;1
Bréchot C. [Biology of hepatitis C viruses: clinical implications] Rev Med Interne 1997;18;11
Brechot C. [Cell division: fundamental aspects] Ann Pathol 1997;17 Suppl 5
Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M, Carrington M, Bréchot C, Sobczak-Thépot J. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 1997;15;1

1996

Strassburg CP, Alex B, Zindy F, Gerken G, Lüttig B, Meyer zum Büschenfelde KH, Bréchot C, Manns MP. Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic autoimmune diseases. J. Hepatol. 1996;25;6
Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C. HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells. Am. J. Physiol. 1996;271;6 Pt 1
Bréchot C. Hepatitis C virus: molecular biology and genetic variability. Dig. Dis. Sci. 1996;41;12 Suppl
Ka MM, Herve P, Leguenno B, Ndiaye MF, Diop TM, Diop B, Dangou JM, Bao O, Brechot C. [Low prevalence of ant-hepatitis c virus antibodies in hepatocellular carcinoma in Senegal] Ann Gastroenterol Hepatol (Paris) 1996;31;6
Minami M, Poussin K, Kew M, Okanoue T, Bréchot C, Paterlini P. Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers. Gastroenterology 1996;111;3
Arbuthnot PB, Bralet MP, Le Jossic C, Dedieu JF, Perricaudet M, Bréchot C, Ferry N. In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector. Hum. Gene Ther. 1996;7;13
Fornairon S, Pol S, Legendre C, Carnot F, Mamzer-Bruneel MF, Brechot C, Kreis H. The long-term virologic and pathologic impact of renal transplantation on chronic hepatitis B virus infection. Transplantation 1996;62;2
Brechot C. Hepatitis B and C viruses and primary liver cancer. Baillieres Clin. Gastroenterol. 1996;10;2
D'Errico A, Fiorentino M, Ponzetto A, Daikuhara Y, Tsubouchi H, Brechot C, Scoazec JY, Grigioni WF. Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions: its specific receptor c-met does. Hepatology 1996;24;1
Pol S, Cavalcanti R, Carnot F, Legendre C, Driss F, Chaix ML, Thervet E, Chkoff N, Brechot C, Berthelot P, Kreis H. Azathioprine hepatitis in kidney transplant recipients. A predisposing role of chronic viral hepatitis. Transplantation 1996;61;12
Brechot C, Nalpas B, Feitelson MA. Interactions between alcohol and hepatitis viruses in the liver. Clin. Lab. Med. 1996;16;2
Bréchot C. [Hepatitis C virus. Structure and genetic variability] Bull. Acad. Natl. Med. 1996;180;6
Kremsdorf D, Garreau F, Capel F, Petit MA, Brechot C. In vivo selection of a hepatitis B virus mutant with abnormal viral protein expression. J. Gen. Virol. 1996;77 ( Pt 5)
Bralet MP, Calise D, Brechot C, Ferry N. In vivo cell lineage analysis during chemical hepatocarcinogenesis using retroviral-mediated gene transfer. Lab. Invest. 1996;74;5
Desdouets C, Ory C, Matesic G, Soussi T, Bréchot C, Sobczak-Thépot J. ATF/CREB site mediated transcriptional activation and p53 dependent repression of the cyclin A promoter. FEBS Lett. 1996;385;1-2
Pawlotsky JM, Lunel F, Zarski JP, Laurent-Puig P, Bréchot C. [Biological diagnosis of hepatitis C virus infection. Role of serological and molecular tests] Gastroenterol. Clin. Biol. 1996;20;2
Zylberberg H, Jiang J, Pialoux G, Driss F, Carnot F, Dubois F, Brechot C, Berthelot P, Pol S. Alpha-interferon for chronic active hepatitis B in human immunodeficiency virus-infected patients. Gastroenterol. Clin. Biol. 1996;20;11

1995

Arbuthnot P, Bralet MP, Thomassin H, Danan JL, Bréchot C, Ferry N. Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by alpha-fetoprotein but not insulinlike growth factor II regulatory sequences. Hepatology 1995;22;6
Desdouets C, Fabre M, Gauthier F, Bréchot C, Sobczak-Thépot J. Proliferation and differentiation of a human hepatoblastoma transplanted in the Nude mouse. J. Hepatol. 1995;23;5
Moldvay J, Deny P, Pol S, Brechot C, Lamas E. [In situ hybridization for the detection of hepatitis C virus RNA in mononuclear cells of peripheral blood from infected patients] Orv Hetil 1995;136;42
Nalpas B, Feitelson M, Bréchot C, Rubin E. Alcohol, hepatotropic viruses, and hepatocellular carcinoma. Alcohol. Clin. Exp. Res. 1995;19;5
Minami M, Poussin K, Bréchot C, Paterlini P. A novel PCR technique using Alu-specific primers to identify unknown flanking sequences from the human genome. Genomics 1995;29;2
Nalpas B, Romeo R, Pol S, Thiers V, Carnot F, Berthelot P, Brechot C. Serum hepatitis C virus (HCV) RNA: a reliable tool for evaluating HCV-related liver disease in anti-HCV-positive blood donors with persistently normal alanine aminotransferase values. Transfusion 1995;35;9
Giannini C, Thiers V, Nousbaum JB, Stuyver L, Maertens G, Bréchot C. Comparative analysis of two assays for genotyping hepatitis C virus based on genotype-specific primers or probes. J. Hepatol. 1995;23;3
Ganne-Carrié N, Kremsdorf D, Garreau F, Thévenin M, Petit MA, Nalpas B, Bréchot C. Effects of ethanol on hepatitis B virus Pre-S/S gene expression in the human hepatocellular carcinoma derived HEP G2 hepatitis B DNA positive cell line. J. Hepatol. 1995;23;2
Rosmorduc O, Petit MA, Pol S, Capel F, Bortolotti F, Berthelot P, Brechot C, Kremsdorf D. In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA. Hepatology 1995;22;1
Paterlini P, Flejou JF, De Mitri MS, Pisi E, Franco D, Bréchot C. Structure and expression of the cyclin A gene in human primary liver cancer. Correlation with flow cytometric parameters. J. Hepatol. 1995;23;1
Rosenberg AR, Zindy F, Le Deist F, Mouly H, Métézeau P, Bréchot C, Lamas E. Overexpression of human cyclin A advances entry into S phase. Oncogene 1995;10;8
Féray C, Gigou M, Samuel D, Paradis V, Mishiro S, Maertens G, Reynés M, Okamoto H, Bismuth H, Bréchot C. Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. Gastroenterology 1995;108;4
Nalpas B, Pol S, Thépot V, Berthelot P, Brechot C. Hepatocellular carcinoma in alcoholics. Alcohol 1995;12;2
Pol S, Thiers V, Nousbaum JB, Legendre C, Berthelot P, Kreis H, Brechot C. The changing relative prevalence of hepatitis C virus genotypes: evidence in hemodialyzed patients and kidney recipients. Gastroenterology 1995;108;2
Nousbaum JB, Pol S, Nalpas B, Landais P, Berthelot P, Bréchot C. Hepatitis C virus type 1b (II) infection in France and Italy. Collaborative Study Group. Ann. Intern. Med. 1995;122;3
Romeo R, Pol S, Demeret C, Thiers V, Kremsdorf D, Cuillerier E, Berthelot P, Brechot C. Evidence of non-A, non-B, non-C infection in chronic hepatitis by polymerase chain reaction testing for hepatitis B and C viruses. J. Hepatol. 1995;22;2
Paterlini P, Poussin K, Kew M, Franco D, Brechot C. Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 1995;21;2
Bréchot C. [Hepatitis B and C viruses and primary liver cancer] Rev Prat 1995;45;2
Jiang JJ, Dubois F, Driss F, Carnot F, Thepot V, Pol S, Berthelot P, Brechot C, Nalpas B. Clinical impact of drug addiction in alcoholics. Alcohol Alcohol. 1995;30;1
Desdouets C, Sobczak-Thépot J, Murphy M, Bréchot C. Cyclin A: function and expression during cell proliferation. Prog Cell Cycle Res 1995;1
Bréchot C, Minami M, De Mitri S, Paterlini P. Hepatitis B and C viruses in hepatitis B surface antigen negative hepatocellular carcinoma patients. Int. Symp. Princess Takamatsu Cancer Res. Fund 1995;25
Aubin JT, Boulay D, Chapus A, Bréchot C, Laure F, Agut H. Evaluation of a new non-isotopic sandwich hybridization for the detection of HIV1-specific PCR products. Res. Virol. 1995;146;1

1994

Féray C, Gigou M, Samuel D, Paradis V, Wilber J, David MF, Urdea M, Reynes M, Bréchot C, Bismuth H. The course of hepatitis C virus infection after liver transplantation. Hepatology 1994;20;5
Poussin K, Harter-Chaput A, Sayada C, Bréchot C. Evaluation of the amplicor HIV1 DNA diagnosis test. Res. Virol. 1994;145;6
Verdon R, Pol S, Landais P, Mattlinger B, Carnot F, Brechot C, Busson M, Kreis H. Absence of association between HLA antigens and chronicity of viral hepatitis in haemodialyzed patients. J. Hepatol. 1994;21;3
Xu LZ, Larzul D, Delaporte E, Bréchot C, Kremsdorf D. Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon). J. Gen. Virol. 1994;75 ( Pt 9)
Dény P, Fattovich G, Le Gal F, Giustina G, Lecot C, Morsica G, Poinsot H, Alberti A, Bréchot C. Polymerase-chain-reaction-based semi-quantification of hepatitis D viraemia in patients treated with high doses of alpha 2b interferon. Res. Virol. 1994;145;5
Romeo R, Pol S, Berthelot P, Brechot C. Eradication of hepatitis C virus RNA after alpha-interferon therapy. Ann. Intern. Med. 1994;121;4
Calmus Y, Marcellin P, Beaurain G, Chatenoud L, Bréchot C. Distribution of hepatitis B virus DNA sequences in different peripheral blood mononuclear cell subsets in HBs antigen-positive and negative patients. Eur. J. Clin. Invest. 1994;24;8
Bréchot C. Hepatitis C virus genetic variability: clinical implications. Am. J. Gastroenterol. 1994;89;8 Suppl
Pol S, Driss F, Michel ML, Nalpas B, Berthelot P, Brechot C. Specific vaccine therapy in chronic hepatitis B infection. Lancet 1994;344;8918
Henglein B, Chenivesse X, Wang J, Eick D, Bréchot C. Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc. Natl. Acad. Sci. U.S.A. 1994;91;12
Simmonds P, Alberti A, Alter HJ, Bonino F, Bradley DW, Brechot C, Brouwer JT, Chan SW, Chayama K, Chen DS. A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology 1994;19;5
Bralet MP, Branchereau S, Brechot C, Ferry N. Cell lineage study in the liver using retroviral mediated gene transfer. Evidence against the streaming of hepatocytes in normal liver. Am. J. Pathol. 1994;144;5
Christa L, Simon MT, Flinois JP, Gebhardt R, Brechot C, Lasserre C. Overexpression of glutamine synthetase in human primary liver cancer. Gastroenterology 1994;106;5
Ackerman Z, Wands JR, Gazitt Y, Brechot C, Kew MC, Shouval D. Enhancement of HBsAg detection in serum of patients with chronic liver disease following removal of circulating immune complexes. J. Hepatol. 1994;20;3
D'Errico A, Grigioni WF, Fiorentino M, Baccarini P, Lamas E, De Mitri S, Gozzetti G, Mancini AM, Brechot C. Expression of insulin-like growth factor II (IGF-II) in human hepatocellular carcinomas: an immunohistochemical study. Pathol. Int. 1994;44;2
Christa L, Felin M, Morali O, Simon MT, Lasserre C, Brechot C, Sève AP. The human HIP gene, overexpressed in primary liver cancer encodes for a C-type carbohydrate binding protein with lactose binding activity. FEBS Lett. 1994;337;1
Marcellin P, Samuel D, Areias J, Loriot MA, Arulnaden JL, Gigou M, David MF, Bismuth A, Reynes M, Bréchot C. Pretransplantation interferon treatment and recurrence of hepatitis B virus infection after liver transplantation for hepatitis B-related end-stage liver disease. Hepatology 1994;19;1
Pol S, Wesenfelder L, Dubois F, Roingeard P, Carnot F, Driss F, Brechot C, Goudeau A, Berthelot P. Influence of human immunodeficiency virus infection on hepatitis delta virus superinfection in chronic HBsAg carriers. J. Viral Hepat. 1994;1;2
Moldvay J, Deny P, Pol S, Brechot C, Lamas E. Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization. Blood 1994;83;1

1993

De Mitri MS, Pisi E, Bréchot C, Paterlini P. Low frequency of allelic loss in the cyclin A gene in human hepatocellular carcinomas: a study based on PCR. Liver 1993;13;5
Housset C, Lamas E, Courgnaud V, Boucher O, Girard PM, Marche C, Brechot C. Presence of HIV-1 in human parenchymal and non-parenchymal liver cells in vivo. J. Hepatol. 1993;19;2
Léonard G, Chaput A, Courgnaud V, Sangaré A, Denis F, Brechot C. Characterization of dual HIV-1 and HIV-2 serological profiles by polymerase chain reaction. AIDS 1993;7;9
Romeo R, Thiers V, Driss F, Berthelot P, Nalpas B, Brechot C. Hepatitis C virus RNA in serum of blood donors with or without elevated transaminase levels. Transfusion 1993;33;8
Pol S, Driss F, Carnot F, Michel ML, Berthelot P, Brechot C. [Efficacy of immunotherapy with vaccination against hepatitis B virus on virus B multiplication] C. R. Acad. Sci. III, Sci. Vie 1993;316;7
Kremsdorf D, Garreau F, Duclos H, Thiers V, Schellekens H, Petit MA, Bréchot C. Complete nucleotide sequence and viral envelope protein expression of a hepatitis B virus DNA derived from a hepatitis B surface antigen-seronegative patient. J. Hepatol. 1993;18;2
Chenivesse X, Franco D, Bréchot C. MDR1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis. J. Hepatol. 1993;18;2
Nalpas B, Thiers V, Pol S, Driss F, Berthelot P, Brechot C. HCV infection in alcoholics. Gastroenterol. Jpn. 1993;28 Suppl 5
Roudot-Thoraval F, Pawlotsky JM, Thiers V, Deforges L, Girollet PP, Guillot F, Huraux C, Aumont P, Brechot C, Dhumeaux D. Lack of mother-to-infant transmission of hepatitis C virus in human immunodeficiency virus-seronegative women: a prospective study with hepatitis C virus RNA testing. Hepatology 1993;17;5
Sobczak-Thepot J, Harper F, Florentin Y, Zindy F, Brechot C, Puvion E. Localization of cyclin A at the sites of cellular DNA replication. Exp. Cell Res. 1993;206;1
Féray C, Gigou M, Samuel D, Bernuau J, Bismuth H, Bréchot C. Low prevalence of precore mutations in hepatitis B virus DNA in fulminant hepatitis type B in France. J. Hepatol. 1993;18;1
Thiers V, Lunel F, Valla D, Azar N, Fretz C, Frangeul L, Huraux JM, Opolon P, Brechot C. Post-transfusional anti-HCV-negative non-A non-B hepatitis (II) serological and polymerase chain reaction analysis for hepatitis C and hepatitis B viruses. J. Hepatol. 1993;18;1
Bréchot C, Kremsdorf D. Genetic variation of the hepatitis C virus (HCV) genome: random events or a clinically relevant issue? J. Hepatol. 1993;17;3
Dény P, Lecot C, Jeantils V, Ovaguimian L, Krivitzky A, Bréchot C. Polymerase chain reaction-based detection of hepatitis D virus genome in patients infected with human immunodeficiency virus. J. Med. Virol. 1993;39;3
Pol S, Saltiel C, Legendre C, Carnot F, Driss F, Berthelot P, Bréchot C, Ruet C, Kreis H. Efficacy of adenine arabinoside 5'-monophosphate in kidney recipients with chronic active hepatitis B: a pilot study. Transplant. Proc. 1993;25;1 Pt 2
Reynès M, Tricottet V, Samuel D, Sebagh M, Bismuth A, Arulnaden J, Brechot C, Bismuth H. Allograft biopsies in situ hybridization HBVDNA detection of serum HBs Ag-repositive patients treated with anti-HBV immunoprophylaxis after liver transplantation for HBV cirrhosis. Transplant. Proc. 1993;25;1 Pt 2
Féray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, Bismuth H, Bréchot C. Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitis. Gastroenterology 1993;104;2
Paterlini P, Suberville AM, Zindy F, Melle J, Sonnier M, Marie JP, Dreyfus F, Bréchot C. Cyclin A expression in human hematological malignancies: a new marker of cell proliferation. Cancer Res. 1993;53;2
Petit MA, Capel F, Gerken G, Dubanchet S, Bréchot C, Trépo C. Significance and relevance of serum preS1 antigen detection in wild-type and variant hepatitis B virus (HBV) infections. Arch. Virol. Suppl. 1993;8
Fleurette F, Durieux P, Battista RN, Benhamou JP, Degos F, Brechot C, Courouce AM, Janot C, Trepo C. Assessment of screening tests for transfusion-associated non-A non-B hepatitis. Int J Technol Assess Health Care 1993;9;4
Paterlini P, Driss F, Nalpas B, Pisi E, Franco D, Berthelot P, Bréchot C. Persistence of hepatitis B and hepatitis C viral genomes in primary liver cancers from HBsAg-negative patients: a study of a low-endemic area. Hepatology 1993;17;1
Bréchot C. Polymerase chain reaction for the diagnosis of hepatitis B and C viral hepatitis. J. Hepatol. 1993;17 Suppl 3
Bréchot C. Polymerase chain reaction for the diagnosis of viral hepatitis B and C. Gut 1993;34;2 Suppl

1992

Pol S, Dubois F, Mattlinger B, Carnot F, Legendre C, Bréchot C, Berthelot P, Kreis H. Absence of hepatitis delta virus infection in chronic hemodialysis and kidney transplant patients in france. Transplantation 1992;54;6
Lasserre C, Christa L, Simon MT, Vernier P, Bréchot C. A novel gene (HIP) activated in human primary liver cancer. Cancer Res. 1992;52;18
Porchon C, Kremsdorf D, Pol S, Lunel-Fabianni F, Driss F, Opolon P, Berthelot P, Bréchot C. Serum hepatitis C virus RNA and hepatitis B virus DNA in non-A, non-B post-transfusional and sporadic chronic hepatitis. J. Hepatol. 1992;16;1-2
Lamas E, Baccarini P, Housset C, Kremsdorf D, Bréchot C. Detection of hepatitis C virus (HCV) RNA sequences in liver tissue by in situ hybridization. J. Hepatol. 1992;16;1-2
Bréchot C. [Liver cancer and hepatitis B and C virus] Rev Prat 1992;42;13
Wang J, Zindy F, Chenivesse X, Lamas E, Henglein B, Bréchot C. Modification of cyclin A expression by hepatitis B virus DNA integration in a hepatocellular carcinoma. Oncogene 1992;7;8
Zignego AL, Macchia D, Monti M, Thiers V, Mazzetti M, Foschi M, Maggi E, Romagnani S, Gentilini P, Bréchot C. Infection of peripheral mononuclear blood cells by hepatitis C virus. J. Hepatol. 1992;15;3
Gerken G, Gerlich WH, Bréchot C, Thomas HC, Bonino F, de Moura C, Meyer zum Büschenfelde KH. Biological standards for hepatitis B virus assays. J. Hepatol. 1992;15;1-2
Pol S, Legendre C, Saltiel C, Carnot F, Bréchot C, Berthelot P, Mattlinger B, Kreis H. Hepatitis C virus in kidney recipients. Epidemiology and impact on renal transplantation. J. Hepatol. 1992;15;1-2
Nalpas B, Pourcel C, Feldmann G, Housset C, Tiollais P, Bréchot C, Berthelot P, Farza H. Chronic alcohol intoxication decreases the serum level of hepatitis B surface antigen in transgenic mice. J. Hepatol. 1992;15;1-2
Housset C, Pol S, Carnot F, Dubois F, Nalpas B, Housset B, Berthelot P, Brechot C. Interactions between human immunodeficiency virus-1, hepatitis delta virus and hepatitis B virus infections in 260 chronic carriers of hepatitis B virus. Hepatology 1992;15;4
Féray C, Samuel D, Thiers V, Gigou M, Pichon F, Bismuth A, Reynes M, Maisonneuve P, Bismuth H, Bréchot C. Reinfection of liver graft by hepatitis C virus after liver transplantation. J. Clin. Invest. 1992;89;4
Novati R, Thiers V, Monforte AD, Maisonneuve P, Principi N, Conti M, Lazzarin A, Brechot C. Mother-to-child transmission of hepatitis C virus detected by nested polymerase chain reaction. J. Infect. Dis. 1992;165;4
Berk L, Schalm SW, de Man RA, Heytink RA, Berthelot P, Brechot C, Boboc B, Degos F, Marcellin P, Benhamou JP. Failure of acyclovir to enhance the antiviral effect of alpha lymphoblastoid interferon on HBe-seroconversion in chronic hepatitis B. A multi-centre randomized controlled trial. J. Hepatol. 1992;14;2-3
Nalpas B, Thiers V, Pol S, Driss F, Thepot V, Berthelot P, Brechot C. Hepatitis C viremia and anti-HCV antibodies in alcoholics. J. Hepatol. 1992;14;2-3
Christa L, Zarski JP, Nalpas B, Augereau C, Bréchot C. Nested polymerase chain reaction on cellular DNA in plasma: a rapid method to investigate the collagen type I A2 MspI polymorphic restriction site in alcoholic patients. Hum. Genet. 1992;88;5
Gerken G, Paterlini P, Kremsdorf D, Petit MA, Manns M, Meyer zum Büschenfelde KH, Brechot C. Clinical significance of the polymerase chain reaction (PCR) assay in chronic HBV carriers. Arch. Virol. Suppl. 1992;4
Courgnaud V, Lauré F, Fultz PN, Montagnier L, Bréchot C, Sonigo P. Genetic differences accounting for evolution and pathogenicity of simian immunodeficiency virus from a sooty mangabey monkey after cross-species transmission to a pig-tailed macaque. J. Virol. 1992;66;1
Zindy F, Lamas E, Schmidt S, Kirn A, Brechot C. Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells. J. Hepatol. 1992;14;1
Bréchot C. [Use of polymerase chain reaction (PCR) for the diagnosis of hepatitis C virus infections] Ann Med Interne (Paris) 1992;143;6

1991

Pol S, Legendre C, Saltiel C, Carnot F, Bréchot C, Berthelot P, Mattlinger B, Kreis H. [Hepatitis C in kidney recipients. Epidemiology and impact on kidney transplantation] Presse Med 1991;20;40
Kremsdorf D, Porchon C, Kim JP, Reyes GR, Bréchot C. Partial nucleotide sequence analysis of a French hepatitis C virus: implications for HCV genetic variability in the E2/NS1 protein. J. Gen. Virol. 1991;72 ( Pt 10)
Terré S, Petit MA, Bréchot C. Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo. J. Virol. 1991;65;10
Degos F, Maisonneuve P, Thiers V, Noël L, Erlinger S, Bréchot C, Benhamou JP. Neonatal transmission of HCV from mother with chronic hepatitis. Lancet 1991;338;8769
Cariani E, Dubois N, Lasserre C, Briand P, Brechot C. Insulin-like growth factor II (IGF-II) mRNA expression during hepatocarcinogenesis in transgenic mice. J. Hepatol. 1991;13;2
Gerken G, Kremsdorf D, Capel F, Petit MA, Dauguet C, Manns MP, Meyer zum Büschenfelde KH, Brechot C. Hepatitis B defective virus with rearrangements in the preS gene during chronic HBV infection. Virology 1991;183;2
Paterlini P, Bréchot C. The detection of hepatitis B virus (HBV) in HBsAG negative individuals with primary liver cancer. Dig. Dis. Sci. 1991;36;8
Tran A, Kremsdorf D, Capel F, Housset C, Dauguet C, Petit MA, Brechot C. Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection. J. Virol. 1991;65;7
Lamas E, Zindy F, Seurin D, Guguen-Guillouzo C, Brechot C. Expression of insulin-like growth factor II and receptors for insulin-like growth factor II, insulin-like growth factor I and insulin in isolated and cultured rat hepatocytes. Hepatology 1991;13;5
Samuel D, Bismuth A, Mathieu D, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, Bismuth H. Passive immunoprophylaxis after liver transplantation in HBsAg-positive patients. Lancet 1991;337;8745
Cariani E, Lasserre C, Kemeny F, Franco D, Brechot C. Expression of insulin-like growth factor II, alpha-fetoprotein and hepatitis B virus transcripts in human primary liver cancer. Hepatology 1991;13;4
Courgnaud V, Lauré F, Brossard A, Bignozzi C, Goudeau A, Barin F, Bréchot C. Frequent and early in utero HIV-1 infection. AIDS Res. Hum. Retroviruses 1991;7;3
Dény P, Zignego AL, Rascalou N, Ponzetto A, Tiollais P, Bréchot C. Nucleotide sequence analysis of three different hepatitis delta viruses isolated from a woodchuck and humans. J. Gen. Virol. 1991;72 ( Pt 3)
Samuel D, Bismuth A, Serres C, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, Bismuth H. HBV infection after liver transplantation in HBsAg positive patients: experience with long-term immunoprophylaxis. Transplant. Proc. 1991;23;1 Pt 2
Vanhems P, Bresson-Hadni S, Vuitton DA, Miguet JP, Gillet M, Lab M, Brechot C. Long-term survival without immunosuppression in HIV-positive liver-graft recipient. Lancet 1991;337;8733
Gerken G, Kremsdorf D, Petit MA, Manns M, Meyer zum Büschenfelde KH, Bréchot C. Hepatitis B defective virus with rearrangements in the preS gene during HBV chronic infection. J. Hepatol. 1991;13 Suppl 4
Nalpas B, Driss F, Pol S, Hamelin B, Housset C, Brechot C, Berthelot P. Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease. J. Hepatol. 1991;12;1
Nalpas B, Driss F, Pol S, Hamelin B, Housset C, Brechot C, Berthelot P. Hepatitis C infection in alcoholics. Alcohol Alcohol Suppl 1991;1
Levrero M, Stemler M, Pasquinelli C, Alberti A, Jean-Jean O, Franco A, Balsano C, Diop D, Brechot C, Melegari M. Significance of anti-HBx antibodies in hepatitis B virus infection. Hepatology 1991;13;1
Driss F, Zarski JP, Courouce AM, Eme D, Brechot C, Berthelot P, Tron F, Nalpas B. [Significance of isolated anti-HBs antibodies in subjects not vaccinated against hepatitis B viruses] Gastroenterol. Clin. Biol. 1991;15;6-7
Lamas E, Le Bail B, Housset C, Boucher O, Bréchot C. Localization of insulin-like growth factor-II and hepatitis B virus mRNAs and proteins in human hepatocellular carcinomas. Lab. Invest. 1991;64;1
Bréchot C, Kremsdorf D, Paterlini P, Thiers V. Hepatitis B virus DNA in HBsAg-negative patients. Molecular characterization and clinical implications. J. Hepatol. 1991;13 Suppl 4
Terré S, Rosmorduc O, Kremsdorf D, Petit MA, Bréchot C. Reverse transcription and packaging of hepatitis B virus (HBV)-RNA generates in vivo defective serum HBV particles. J. Hepatol. 1991;13 Suppl 4
Kremsdorf D, Porchon C, Brechot C. Hepatitis C virus (HCV)-RNA in non-A, non-B chronic hepatitis in France. Nucleotide sequence of a French HCV isolate. J. Hepatol. 1991;13 Suppl 4

1990

Blanquet V, Wang JA, Chenivesse X, Henglein B, Garreau F, Bréchot C, Turleau C. Assignment of a human cyclin A gene to 4q26-q27. Genomics 1990;8;3
Brechot C. ["Non-A-non-B" viruses have been identified] Presse Med 1990;19;34
Pol S, Driss F, Devergie A, Brechot C, Berthelot P, Gluckman E. Is hepatitis C virus involved in hepatitis-associated aplastic anemia? Ann. Intern. Med. 1990;113;6
Cariani E, Seurin D, Lasserre C, Franco D, Binoux M, Brechot C. Expression of insulin-like growth factor II (IGF-II) in human primary liver cancer: mRNA and protein analysis. J. Hepatol. 1990;11;2
Bréchot C. Polymerase chain reaction. A new tool for the study of viral infections in hepatology. J. Hepatol. 1990;11;1
Féray C, Zignego AL, Samuel D, Bismuth A, Reynes M, Tiollais P, Bismuth H, Brechot C. Persistent hepatitis B virus infection of mononuclear blood cells without concomitant liver infection. The liver transplantation model. Transplantation 1990;49;6
Dazza MC, Meneses LV, Girard PM, Villaroel C, Bréchot C, Larouzé B. Hepatitis C virus antibody and hepatocellular carcinoma. Lancet 1990;335;8699
Pol S, Debure A, Degott C, Carnot F, Legendre C, Brechot C, Kreis H. Chronic hepatitis in kidney allograft recipients. Lancet 1990;335;8694
Housset C, Boucher O, Girard PM, Leibowitch J, Saimot AG, Bréchot C, Marche C. Immunohistochemical evidence for human immunodeficiency virus-1 infection of liver Kupffer cells. Hum. Pathol. 1990;21;4
Housset C, Lamas E, Bréchot C. Detection of HIV1 RNA and p24 antigen in HIV1-infected human liver. Res. Virol. 1990;141;2
Wang J, Chenivesse X, Henglein B, Bréchot C. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 1990;343;6258
Brechot C. [Hepatitis C virus: a discovery of molecular biology] Gastroenterol. Clin. Biol. 1990;14;1

1989

Leblond-Francillard M, Augereau C, Nalpas B, Trinchet JC, Hartmann DJ, Berthelot P, Beaugrand M, Brechot C. Liver collagen mRNA and serum amino-terminal peptide of type III procollagen (PIIINP) levels in patients with alcoholic liver disease. J. Hepatol. 1989;9;3
Buetow KH, Murray JC, Israel JL, London WT, Smith M, Kew M, Blanquet V, Brechot C, Redeker A, Govindarajah S. Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A. 1989;86;22
Marcellin P, Ouzan D, Degos F, Brechot C, Metman EH, Degott C, Chevalier M, Berthelot P, Trepo C, Benhamou JP. Randomized controlled trial of adenine arabinoside 5'-monophosphate in chronic active hepatitis B: comparison of the efficacy in heterosexual and homosexual patients. Hepatology 1989;10;3
Pol S, Dubois F, Roingeard P, Zignego L, Housset C, Brechot C, Goudeau A, Berthelot P. Hepatitis delta virus infection in French male HBsAg-positive homosexuals. Hepatology 1989;10;3
Tron F, Degos F, Bréchot C, Couroucé AM, Goudeau A, Marie FN, Adamowicz P, Saliou P, Laplanche A, Benhamou JP. Randomized dose range study of a recombinant hepatitis B vaccine produced in mammalian cells and containing the S and PreS2 sequences. J. Infect. Dis. 1989;160;2
Zarski JP, Kuhns M, Berck L, Degos F, Schalm SW, Tiollais P, Bréchot C. Comparison of a quantitative standardized HBV-DNA assay and a classical spot hybridization test in chronic active hepatitis B patients undergoing antiviral therapy. Res. Virol. 1989;140;4
Dény P, Debure A, Agut H, Berche P, Degos F, Nicolas JC, Kreis H, Bréchot C. Detection of human cytomegalovirus DNA in liver biopsies from patients with cytomegalovirus-related liver disease. Res. Virol. 1989;140;4
Roudot-Thoraval F, Kouadja F, Wirquin V, Thiers V, Avons P, Brechot C, Dhumeaux D. [Prevalence of HBs antigen carriers and markers of B virus replication in a population of pregnant women, in France] Gastroenterol. Clin. Biol. 1989;13;4
Bréchot C. Hepatitis B virus in alcoholic liver disease with hepatocellular carcinoma. Hepatology 1989;9;3
Reynès M, Zignego L, Samuel D, Fabiani B, Gugenheim J, Tricottet V, Brechot C, Bismuth H. Graft hepatitis delta virus reinfection after orthotopic liver transplantation in HDV cirrhosis. Transplant. Proc. 1989;21;1 Pt 2
Driss F, Boboc B, Zarski JP, Cals MJ, Pol S, Eme D, Ekindjian OG, Courouce AM, Brechot C, Berthelot P. An epidemiological and clinical study of transaminase levels and hepatitis B antibodies in 1,100 blood donors. Vox Sang. 1989;57;1

1988

Cariani E, Lasserre C, Seurin D, Hamelin B, Kemeny F, Franco D, Czech MP, Ullrich A, Brechot C. Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis. Cancer Res. 1988;48;23
Gripon P, Diot C, Thézé N, Fourel I, Loreal O, Brechot C, Guguen-Guillouzo C. Hepatitis B virus infection of adult human hepatocytes cultured in the presence of dimethyl sulfoxide. J. Virol. 1988;62;11
Blanquet V, Garreau F, Chenivesse X, Brechot C, Turleau C. Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer. Hum. Genet. 1988;80;3
Laure F, Courgnaud V, Rouzioux C, Blanche S, Veber F, Burgard M, Jacomet C, Griscelli C, Brechot C. Detection of HIV1 DNA in infants and children by means of the polymerase chain reaction. Lancet 1988;2;8610
Pariente EA, Goudeau A, Dubois F, Degott C, Gluckman E, Devergie A, Brechot C, Schenmetzler C, Bernuau J. Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation. Dig. Dis. Sci. 1988;33;9
Larzul D, Guigue F, Sninsky JJ, Mack DH, Bréchot C, Guesdon JL. Detection of hepatitis B virus sequences in serum by using in vitro enzymatic amplification. J. Virol. Methods 1988;20;3
Cariani E, Bréchot C. Detection of DNA sequences by Southern blot. Ric Clin Lab 1988;18;2-3
Pasquinelli C, Garreau F, Bougueleret L, Cariani E, Grzeschik KH, Thiers V, Croissant O, Hadchouel M, Tiollais P, Bréchot C. Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors. J. Virol. 1988;62;2
Bréchot C. [Diagnosis and prevention of hepatitis B virus infections: applied example of genetic recombinations] Rev Prat 1988;38;1
Degos F, Lugassy C, Degott C, Debure A, Carnot F, Theirs V, Tiollais P, Kreis H, Brechot C. Hepatitis B virus and hepatitis B-related viral infection in renal transplant recipients. A prospective study of 90 patients. Gastroenterology 1988;94;1
Hadchouel M, Pasquinelli C, Fournier JG, Hugon RN, Scotto J, Bernard O, Brechot C. Detection of mononuclear cells expressing hepatitis B virus in peripheral blood from HBsAg positive and negative patients by in situ hybridisation. J. Med. Virol. 1988;24;1

1987

Pol S, Thiers V, Nalpas B, Degos F, Gazengel C, Carnot F, Tiollais P, Wands JR, Berthelot P, Brechot C. Monoclonal anti-HBs antibodies radioimmunoassay and serum HBV-DNA hybridization as diagnostic tools of HBV infection: relative prevalence among HBsAg-negative alcoholics, patients with chronic hepatitis or hepatocellular carcinomas and blood donors. Eur. J. Clin. Invest. 1987;17;6
Larzul D, Thiers V, Courouce AM, Bréchot C, Guesdon JL. Non-radioactive hepatitis B virus DNA probe for detection of HBV-DNA in serum. J. Hepatol. 1987;5;2
Ouzan D, Degos F, Marcellin P, Linberg J, Chevallier M, Degott C, Bréchot C, Chossegros P, Weiss AM, Hirtz J. [Vidarabine treatment of chronic active hepatitis associated with hepatitis B virus multiplication. A randomized multicenter study] Gastroenterol. Clin. Biol. 1987;11;8-9
Bréchot C. Hepatitis B virus (HBV) and hepatocellular carcinoma. HBV DNA status and its implications. J. Hepatol. 1987;4;2
Laure F, Leonard R, Mbayo K, Lurhuma Z, Kayembe N, Brechot C, Sarin PS, Sarngadharan M, Wong-Staal F, Gallo RC. Genomic diversity of Zairian HIV isolates: biological characteristics and clinical manifestation of HIV infection. AIDS Res. Hum. Retroviruses 1987;3;4

1986

Chaussade S, Thiers V, Boboc B, Housset C, Bréchot C, Degos F. [HBe antigen and B virus DNA in patients with chronic active hepatitis] Gastroenterol. Clin. Biol. 1986;10;11
Hadengue A, Thiers V, Santelli D, Bismuth H, Bréchot C. [Presence of DNA sequences of hepatitis B virus in a fibrolamellar carcinoma of the liver] Gastroenterol. Clin. Biol. 1986;10;10
Budkowska A, Riottot MM, Dubreuil P, Lazizi Y, Brechot C, Sobczak E, Petit MA, Pillot J. Monoclonal antibody recognizing pre-S(2) epitope of hepatitis B virus: characterization of pre-S(2) epitope and anti-pre-S(2) antibody. J. Med. Virol. 1986;20;2
Wands JR, Fujita YK, Isselbacher KJ, Degott C, Schellekens H, Dazza MC, Thiers V, Tiollais P, Brechot C. Identification and transmission of hepatitis B virus-related variants. Proc. Natl. Acad. Sci. U.S.A. 1986;83;17
Thiers V, Bouchardeau F, Courouce AM, Tiollais P, Brechot C. [Hepatitis B virus DNA as a marker of viral multiplication: comparison with HBe antigen and anti-HBe antibody] Presse Med 1986;15;26
Berthelot P, Neurath R, Courouce AM, Brechot C, Degos F, Tron F, Girard M. Hepatitis B vaccines with pre-S gene product. Lancet 1986;1;8490
Pol S, Nalpas B, Bezeaud A, Bréchot C, Berthelot P. [Occurrence of increased alpha-fetoprotein in non-neoplastic hepatopathies of alcoholic or non-alcoholic origin] Gastroenterol. Clin. Biol. 1986;10;2
Degos F, Duhamel G, Brechot C, Nalpas B, Courouce AM, Tron F, Berthelot P. Hepatitis B vaccination in chronic alcoholics. J. Hepatol. 1986;2;3
Pasquinelli C, Lauré F, Chatenoud L, Beaurin G, Gazengel C, Bismuth H, Degos F, Tiollais P, Bach JF, Bréchot C. Hepatitis B virus DNA in mononuclear blood cells. A frequent event in hepatitis B surface antigen-positive and -negative patients with acute and chronic liver disease. J. Hepatol. 1986;3;1

1985

Saddi RS, Ebelin P, Pouliquen A, Gautreau C, Durand J, Jammet P, Courouce AM, Brechot C, Franco D, Thibult N. Hepatitis B vaccination and idiopathic haemochromatosis. Lancet 1985;2;8463
Pontisso P, Chemello L, Fattovich G, Alberti A, Realdi G, Brechot C. Relationship between HBcAg in serum and liver and HBV replication in patients with HBsAg-positive chronic liver disease. J. Med. Virol. 1985;17;2
Laure F, Zagury D, Saimot AG, Gallo RC, Hahn BH, Brechot C. Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex. Science 1985;229;4713
Hadchouel M, Scotto J, Huret JL, Molinie C, Villa E, Degos F, Brechot C. Presence of HBV DNA in spermatozoa: a possible vertical transmission of HBV via the germ line. J. Med. Virol. 1985;16;1
Scotto J, Hadchouel M, Wain-Hobson S, Sonigo P, Couroucé AM, Tiollais P, Bréchot C. Hepatitis B virus DNA in Dane particles: evidence for the presence of replicative intermediates. J. Infect. Dis. 1985;151;4
Wands JR, Isselbacher KJ, Brechot C, Tiollais P. Monoclonal radioimmunoassays and HBV-DNA hybridisation in hepatocellular carcinoma. Lancet 1985;1;8426
Bréchot C, Degos F, Lugassy C, Thiers V, Zafrani S, Franco D, Bismuth H, Trépo C, Benhamou JP, Wands J. Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N. Engl. J. Med. 1985;312;5
Nalpas B, Berthelot P, Thiers V, Duhamel G, Courouce AM, Tiollais P, Brechot C. Hepatitis B virus multiplication in the absence of usual serological markers. A study of 146 chronic alcoholics. J. Hepatol. 1985;1;2
Krogsgaard K, Kryger P, Aldershvile J, Andersson P, Brechot C. Hepatitis B virus DNA in serum from patients with acute hepatitis B. Hepatology 1985;5;1

1984

Bréchot C. [Hepatitis B virus: a better knowledge of its structure and variations in the expression of the viral disease] Gastroenterol. Clin. Biol. 1984;8;8-9
Pontisso P, Poon MC, Tiollais P, Brechot C. Detection of hepatitis B virus DNA in mononuclear blood cells. Br Med J (Clin Res Ed) 1984;288;6430
Dejean A, Lugassy C, Zafrani S, Tiollais P, Brechot C. Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus. J. Gen. Virol. 1984;65 ( Pt 3)
Brechot C, Bernuau J, Thiers V, Dubois F, Goudeau A, Rueff B, Tiollais P, Benhamou JP. Multiplication of hepatitis B virus in fulminant hepatitis B. Br Med J (Clin Res Ed) 1984;288;6413

1983

Degos F, Brechot C, Nalpas B, Duhamel G, Courouce AM, Tron F, Berthelot P. Hepatitis B vaccination and alcoholic cirrhosis. Lancet 1983;2;8365-66
Scotto J, Hadchouel M, Hery C, Alvarez F, Yvart J, Tiollais P, Bernard O, Brechot C. Hepatitis B virus DNA in children's liver diseases: detection by blot hybridisation in liver and serum. Gut 1983;24;7
Scotto J, Hadchouel M, Hery C, Yvart J, Tiollais P, Brechot C. Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results for other viral markers. Hepatology 1983;3;3
Dejean A, Brechot C, Tiollais P, Wain-Hobson S. Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5. Proc. Natl. Acad. Sci. U.S.A. 1983;80;9
Guguen-Guillouzo C, Clement B, Campion JP, Brechot C, Fauchet R, Brissot P, Guillouzo A, Bourel M. [Excretion of HBs and HBe antigens by normal human adult hepatocytes infected in vitro by hepatitis B virus] Presse Med 1983;12;19

1982

Bréchot C. [What is the role of hepatitis B virus in the appearance of hepatocellular carcinomas in patients with alcoholic cirrhosis?] Gastroenterol. Clin. Biol. 1982;6;10
Dejean A, Vitvitski L, Brechot C, Trepo C, Tiollais P, Charnay P. Presence and state of woodchuck hepatitis virus DNA in liver and serum of woodchucks: further analogies with human hepatitis B virus. Virology 1982;121;1
Bréchot C, Nalpas B, Couroucé AM, Duhamel G, Callard P, Carnot F, Tiollais P, Berthelot P. Evidence that hepatitis B virus has a role in liver-cell carcinoma in alcoholic liver disease. N. Engl. J. Med. 1982;306;23
Franco D, Castaing D, Bréchot C, Morin J. [Is aflatoxin B1 a hepatic carcinogen in man?] Gastroenterol. Clin. Biol. 1982;6;2

1981

Brechot C, Hadchouel M, Scotto J, Degos F, Charnay P, Trepo C, Tiollais P. Detection of hepatitis B virus DNA in liver and serum: a direct appraisal of the chronic carrier state. Lancet 1981;2;8250
Bréchot C, Hadchouel M, Scotto J, Fonck M, Potet F, Vyas GN, Tiollais P. State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases. Proc. Natl. Acad. Sci. U.S.A. 1981;78;6
Bréchot C, Tiollais P. [Genetic engineering and the hepatitis B virus] Gastroenterol. Clin. Biol. 1981;5;1
Brechot C, Pourcel C, Louise A, Rain B, Tiollais P. Detection of hepatitis B virus DNA sequences in human hepatocellular carcinoma in an integrated form. Prog. Med. Virol. 1981;27

1980

Brechot C, Trepo C, Ninova-Bradistilova D, Goudeau A, Degott C, Maupas P, Potet F, Benhamou JP. Hepatitis B core antigen in hepatocytes of patients with chronic active hepatitis. Dig. Dis. Sci. 1980;25;8
Brechot C, Pourcel C, Louise A, Rain B, Tiollais P. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 1980;286;5772
Bréchot C, Hecht Y, Ferrier JP. [Endotoxins of Gram-negative bacteria in liver diseases] Gastroenterol. Clin. Biol. 1980;4;4

1979

Tobelem G, Michel H, de la Baume H, Brechot C, Degos L, Schaison G. [Thrombocytopenic purpura during heparinotherapy. Two cases (author's transl)] Nouv Presse Med 1979;8;44

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